Abstract：
:The posterior septum consisting of the triangular septum (TS) and the bed nucleus of the anterior commissure (BAC) is predominantly linked with the medial habenula (MHb) and has been implicated in the control of anxiety and fear responses. However, its anatomical and functional linkage has largely remained elusive. We established a transgenic mouse model in which the TS and BAC projection neurons were visualized by GFP fluorescence and selectively eliminated by immunotoxin-mediated cell targeting. The linkage between the TS/BAC and the MHb constitutes two parallel pathways composed of the TS-ventral MHb, the core part of the interpeduncular nucleus (IPN), and the BAC-dorsal MHb, the peripheral part of the IPN. Ablation of the TS and BAC projection neurons selectively impaired anxiety and enhanced fear responses and learning, respectively. Inputs from the TS and BAC to the MHb are thus segregated by two parallel pathways and play specialized roles in controlling emotional behaviors.
journal_name
Neuronjournal_title
Neuronauthors
Yamaguchi T,Danjo T,Pastan I,Hikida T,Nakanishi Sdoi
10.1016/j.neuron.2013.02.035subject
Has Abstractpub_date
2013-05-08 00:00:00pages
537-44issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(13)00222-5journal_volume
78pub_type
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