Abstract:
:The present study utilized event-related fMRI to address the role of the human perirhinal cortex (PRC), and its interactions with the hippocampus, in memory consolidation. Participants encoded object-based and scene-based associations and then restudied them either after a "long" or "short" delay during which consolidation could occur. We found that BOLD activation in left PRC and hippocampal-PRC functional connectivity were significantly enhanced during the restudy of the long versus short delay word-object pairs. Secondly, hippocampal-PRC connectivity during restudy of the long delay word-object pairs predicted a subsequent reduction in associative forgetting. By contrast, hippocampal-PRC connectivity did not predict subsequent resistance to forgetting for the short delay or novel associations. Together, these results provide evidence for perirhinal-hippocampal interactions in the selective consolidation of object-based associative memories and provide support for the notion that, during early stages of consolidation, memories become more distributed across brain regions.
journal_name
Neuronjournal_title
Neuronauthors
Vilberg KL,Davachi Ldoi
10.1016/j.neuron.2013.07.013subject
Has Abstractpub_date
2013-09-18 00:00:00pages
1232-42issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(13)00613-2journal_volume
79pub_type
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