Abstract:
:Contexts exert bi-directional control over relapse to drug seeking. Contexts associated with drug self-administration promote relapse, whereas contexts associated with the absence of self-administration protect against relapse. The nucleus accumbens shell (AcbSh) is a key brain region determining these roles of context. However, the specific cell types, and projections, by which AcbSh serves these dual roles are unknown. Here, we show that contextual control over relapse and abstinence is embedded within distinct output circuits of dopamine 1 receptor (Drd1) expressing AcbSh neurons. We report anatomical and functional segregation of Drd1 AcbSh output pathways during context-induced reinstatement and extinction of alcohol seeking. The AcbSh→ventral tegmental area (VTA) pathway promotes relapse via projections to VTA Gad1 neurons. The AcbSh→lateral hypothalamus (LH) pathway promotes extinction via projections to LH Gad1 neurons. Targeting these opposing AcbSh circuit contributions may reduce propensity to relapse to, and promote abstinence from, drug use.
journal_name
Neuronjournal_title
Neuronauthors
Gibson GD,Prasad AA,Jean-Richard-Dit-Bressel P,Yau JOY,Millan EZ,Liu Y,Campbell EJ,Lim J,Marchant NJ,Power JM,Killcross S,Lawrence AJ,McNally GPdoi
10.1016/j.neuron.2018.03.033subject
Has Abstractpub_date
2018-05-02 00:00:00pages
512-520.e6issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(18)30239-3journal_volume
98pub_type
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