Abstract:
:We have investigated the specification of noradrenergic neurotransmitter identity in neural crest stem cells (NCSCs). Retroviral expression of both wild-type and dominant-negative forms of the paired homeodomain transcription factor Phox2a indicates a crucial and direct role for this protein (and/or the closely related Phox2b) in the regulation of endogenous tyrosine hydroxylase (TH) and dopamine-beta hydroxylase (DBH) gene expression in these cells. In collaboration with cAMP, Phox2a can induce expression of TH but not of DBH or of panneuronal genes. Phox2 proteins are, moreover, necessary for the induction of both TH and DBH by bone morphogenetic protein 2 (BMP2) (which induces Phox2a/b) and forskolin. They are also necessary for neuronal differentiation. These data suggest that Phox2a/b coordinates the specification of neurotransmitter identity and neuronal fate by cooperating environmental signals in sympathetic neuroblasts.
journal_name
Neuronjournal_title
Neuronauthors
Lo L,Morin X,Brunet JF,Anderson DJdoi
10.1016/s0896-6273(00)80729-1subject
Has Abstractpub_date
1999-04-01 00:00:00pages
693-705issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80729-1journal_volume
22pub_type
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