CNTF, FGF, and NGF collaborate to drive the terminal differentiation of MAH cells into postmitotic neurons.

abstract：:Rhythmic spontaneous electrical activity occurs in many parts of the developing nervous system, where it plays essential roles in the refinement of neural connections. By blocking or slowing this bursting activity, via in ovo drug applications at precise developmental periods, we show that such activity is also requir...

journal_title：Neuron

authors： Hanson MG,Landmesser LT

更新日期：2004-09-02 00:00:00

abstract：:Two articles in this issue of Neuron (Eichner et al. and Clark et al.) attack the problem of explaining how neuronal hardware in Drosophila implements the Reichardt motion detector, one of the most famous computational models in neuroscience, which has proven intractable up to now. ...

journal_title：Neuron

authors： Gabbiani F,Jones PW

更新日期：2011-06-23 00:00:00

abstract：:Genetic deletion of fragile X mental retardation protein (FMRP) has been shown to enhance mGluR-dependent long-term depression (LTD). Herein, we demonstrate that mGluR-LTD induces a transient, translation-dependent increase in FMRP that is rapidly degraded by the ubiquitin-proteasome pathway. Moreover, proteasome inhi...

journal_title：Neuron

authors： Hou L,Antion MD,Hu D,Spencer CM,Paylor R,Klann E

更新日期：2006-08-17 00:00:00

abstract：:The subunit stoichiometry of the mammalian K+ channel KV1.1 (RCK1) was examined by linking together the coding sequences of 2-5 K+ channel subunits in a single open reading frame and tagging the expression of individual subunits with a mutation (Y379K or Y379R) that altered the sensitivity of the channel to block by e...

journal_title：Neuron

authors： Liman ER,Tytgat J,Hess P

更新日期：1992-11-01 00:00:00

abstract：:Amphetamine (AMPH) releases monoamines, transiently stimulates locomotion, and inhibits feeding. Using a genetic approach, we show that mice lacking dopamine (DA-deficient, or DD, mice) are resistant to the hypophagic effects of a moderate dose of AMPH (2 microg/g) but manifest normal AMPH-induced hypophagia after res...

journal_title：Neuron

authors： Cannon CM,Abdallah L,Tecott LH,During MJ,Palmiter RD

更新日期：2004-10-28 00:00:00

abstract：:During development, newly born neurons migrate away from their initial birth sites to their final positions in the mature brain. The neurotrophin BDNF has been shown to regulate the migration of granule cells in the cerebellum. The cellular mechanisms that mediate this chemotactic response have not been resolved. In t...

journal_title：Neuron

authors： Kaplan DR,Miller FD

更新日期：2007-07-05 00:00:00

abstract：VIDEO ABSTRACT:The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are poorly understood. Here, we show that the secreted molecule Sonic Hedgehog (Shh) is involved in synapse formation of a specific cortical circuit. ...

journal_title：Neuron

authors： Harwell CC,Parker PR,Gee SM,Okada A,McConnell SK,Kreitzer AC,Kriegstein AR

更新日期：2012-03-22 00:00:00

abstract：:Successful visual navigation requires a sense of the geometry of the local environment. How do our brains extract this information from retinal images? Here we visually presented scenes with all possible combinations of five scene-bounding elements (left, right, and back walls; ceiling; floor) to human subjects during...

journal_title：Neuron

authors： Henriksson L,Mur M,Kriegeskorte N

更新日期：2019-07-03 00:00:00

abstract：:Classical patterning molecules that were previously implicated in controlling cell fate choices in the nervous system have recently been shown to play additional roles in axon guidance and synaptogenesis. Bone morphogenetic proteins (BMPs), Sonic hedgehog (Shh), Wnts, and fibroblast growth factors (FGFs) all participa...

journal_title：Neuron

authors： Salie R,Niederkofler V,Arber S

更新日期：2005-01-20 00:00:00

abstract：:The rich functional diversity of the nervous system is founded in the specific connectivity of the underlying neural circuitry. Neurons are often preprogrammed to respond to multiple axon guidance signals because they use sequential guideposts along their pathways, but this necessitates a strict spatiotemporal regulat...

journal_title：Neuron

authors： Bonanomi D,Valenza F,Chivatakarn O,Sternfeld MJ,Driscoll SP,Aslanian A,Lettieri K,Gullo M,Badaloni A,Lewcock JW,Hunter T,Pfaff SL

更新日期：2019-05-08 00:00:00

abstract：:Microglia are the immune cells of the brain. Here we show a massive infiltration of highly ramified and elongated microglia within the core of amyloid plaques in transgenic mouse models of Alzheimer's disease (AD). Many of these cells originate from the bone marrow, and the beta-amyloid-40 and -42 isoforms are able to...

journal_title：Neuron

authors： Simard AR,Soulet D,Gowing G,Julien JP,Rivest S

更新日期：2006-02-16 00:00:00

abstract：:Primates can learn to recognize a virtually limitless number of visual objects. A candidate neural substrate for this adult plasticity is the inferior temporal cortex (ITC). Using a large stimulus set, we explored the impact that long-term experience has on the response properties of two classes of neurons in ITC: bro...

journal_title：Neuron

authors： Woloszyn L,Sheinberg DL

更新日期：2012-04-12 00:00:00

abstract：:Historical milestones in neuroscience have come in diverse forms, ranging from the resolution of specific biological mysteries via creative experimentation to broad technological advances allowing neuroscientists to ask new kinds of questions. The continuous development of tools is driven with a special necessity by t...

journal_title：Neuron

authors： Deisseroth K,Schnitzer MJ

更新日期：2013-10-30 00:00:00

abstract：:The sympathetic innervation of rat sweat glands undergoes a target-induced switch from a noradrenergic to a cholinergic and peptidergic phenotype during development. Treatment of cultured sympathetic neurons with sweat gland extracts mimics many of the changes seen in vivo. Extracts induce choline acetyltransferase ac...

journal_title：Neuron

authors： Rao MS,Landis SC

更新日期：1990-12-01 00:00:00

abstract：:The state of the brain and body constantly varies on rapid and slow timescales. These variations contribute to the apparent noisiness of sensory responses at both the neural and the behavioral level. Recent investigations of rapid state changes in awake, behaving animals have provided insight into the mechanisms by wh...

journal_title：Neuron

authors： McGinley MJ,Vinck M,Reimer J,Batista-Brito R,Zagha E,Cadwell CR,Tolias AS,Cardin JA,McCormick DA

更新日期：2015-09-23 00:00:00

abstract：:Evolutionary conservation of members of the NGF family in vertebrates was studied by DNA sequence analysis of PCR fragments for NGF, BDNF, and NT-3 from human, rat, chicken, viper, Xenopus, salmon, and ray. The results showed that the three factors are highly conserved from fishes to mammals. Phylogenetic trees reflec...

journal_title：Neuron

authors： Hallböök F,Ibáñez CF,Persson H

更新日期：1991-05-01 00:00:00

abstract：:The location, size, and number of synapses critically influence the specificity and strength of neural connections. In axons, synaptic vesicle (SV) and active zone (AZ) proteins are transported by molecular motors and accumulate at discrete presynaptic loci. Little is known about the mechanisms coordinating presynapti...

journal_title：Neuron

authors： Wu YE,Huo L,Maeder CI,Feng W,Shen K

更新日期：2013-06-19 00:00:00

abstract：:Sensory systems transform the external world into time-varying spike trains. What features of spiking activity are used to guide behavior? In the mouse olfactory bulb, inhalation of different odors leads to changes in the set of neurons activated, as well as when neurons are activated relative to each other (synchrony...

journal_title：Neuron

authors： Gill JV,Lerman GM,Zhao H,Stetler BJ,Rinberg D,Shoham S

更新日期：2020-10-28 00:00:00

abstract：:When speaking, we dynamically coordinate movements of our jaw, tongue, lips, and larynx. To investigate the neural mechanisms underlying articulation, we used direct cortical recordings from human sensorimotor cortex while participants spoke natural sentences that included sounds spanning the entire English phonetic i...

journal_title：Neuron

authors： Chartier J,Anumanchipalli GK,Johnson K,Chang EF

更新日期：2018-06-06 00:00:00

abstract：:Light-induced photoreceptor apoptosis occurs in many forms of inherited retinal degeneration resulting in blindness in both vertebrates and invertebrates. Though mutations in several photoreceptor signaling proteins have been implicated in triggering this process, the molecular events relating light activation of rhod...

journal_title：Neuron

authors： Kiselev A,Socolich M,Vinós J,Hardy RW,Zuker CS,Ranganathan R

更新日期：2000-10-01 00:00:00

abstract：:In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom ...

journal_title：Neuron

authors： Perisse E,Owald D,Barnstedt O,Talbot CB,Huetteroth W,Waddell S

更新日期：2016-06-01 00:00:00

abstract：:To evaluate the role in synaptic plasticity of ryanodine receptor type 3 (RyR3), which is normally enriched in hippocampal area CA1, we generated RyR3-deficient mice. Mutant mice exhibited facilitated CA1 long-term potentiation (LTP) induced by short tetanus (100 Hz, 100 ms) stimulation. Unlike LTP in wild-type mice, ...

journal_title：Neuron

authors： Futatsugi A,Kato K,Ogura H,Li ST,Nagata E,Kuwajima G,Tanaka K,Itohara S,Mikoshiba K

更新日期：1999-11-01 00:00:00

abstract：:AMPA-type glutamate receptors (AMPARs) play a major role in excitatory synaptic transmission and plasticity. Channel properties are largely dictated by their composition of the four subunits, GluR1-4 (or A-D). Here we show that AMPAR assembly and subunit stoichiometry are determined by RNA editing in the pore loop. We...

journal_title：Neuron

authors： Greger IH,Khatri L,Kong X,Ziff EB

更新日期：2003-11-13 00:00:00

abstract：:The synaptic vesicle protein synaptotagmin I binds Ca2+ and is required for efficient neurotransmitter release. Here, we measure the response time of the C2 domains of synaptotagmin to determine whether synaptotagmin is fast enough to function as a Ca2+ sensor for rapid exocytosis. We report that synaptotagmin is "tun...

journal_title：Neuron

authors： Davis AF,Bai J,Fasshauer D,Wolowick MJ,Lewis JL,Chapman ER

更新日期：1999-10-01 00:00:00

abstract：:Selective synaptic and axonal degeneration are critical aspects of both brain development and neurodegenerative disease. Inhibition of caspase signaling in neurons is a potential therapeutic strategy for neurodegenerative disease, but no neuron-specific modulators of caspase signaling have been described. Using a mass...

journal_title：Neuron

authors： Hertz NT,Adams EL,Weber RA,Shen RJ,O'Rourke MK,Simon DJ,Zebroski H,Olsen O,Morgan CW,Mileur TR,Hitchcock AM,Sinnott Armstrong NA,Wainberg M,Bassik MC,Molina H,Wells JA,Tessier-Lavigne M

更新日期：2019-08-07 00:00:00

abstract：:We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR5(2b,) GluR5(2c), and GluR6. Of these, we show that both GRIP and PICK1 interactions are required to maintain KAR-mediated synaptic function at mossy fiber-CA3 synapses. In a...

journal_title：Neuron

authors： Hirbec H,Francis JC,Lauri SE,Braithwaite SP,Coussen F,Mulle C,Dev KK,Coutinho V,Meyer G,Isaac JT,Collingridge GL,Henley JM

更新日期：2003-02-20 00:00:00

abstract：:Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, provide insight into the role of NMDA receptors in the cell-specific excito...

journal_title：Neuron

authors： Ellerby LM

更新日期：2002-03-14 00:00:00

abstract：:When faced with a crowded visual scene, observers must selectively attend to behaviorally relevant objects to avoid sensory overload. Often this selection process is guided by prior knowledge of a target-defining feature (e.g., the color red when looking for an apple), which enhances the firing rate of visual neurons ...

journal_title：Neuron

authors： Serences JT,Boynton GM

更新日期：2007-07-19 00:00:00

abstract：:Neurotransmitter receptors are central to communication at synapses. Many components of the machinery for neurotransmission are present prior to synapse formation, suggesting a developmental role. Here, evidence is presented that signaling through glycine receptor alpha2 (GlyRalpha2) and GABA(A) receptors plays a role...

journal_title：Neuron

authors： Young TL,Cepko CL

更新日期：2004-03-25 00:00:00

abstract：:Elevation of cAMP can overcome myelin inhibitors to encourage regeneration of the CNS. We show that a consequence of elevated cAMP is the synthesis of polyamines, resulting from an up-regulation of Arginase I, a key enzyme in their synthesis. Inhibiting polyamine synthesis blocks the cAMP effect on regeneration. Eithe...

journal_title：Neuron

authors： Cai D,Deng K,Mellado W,Lee J,Ratan RR,Filbin MT

更新日期：2002-08-15 00:00:00