Abstract：
:We have determined the sequences of isoforms of human tau protein, which differ from previously reported forms by insertions of 29 or 58 amino acids in the amino-terminal region. Complementary DNA cloning shows that the insertions occur in combination with both three and four tandem repeats. RNAase protection assays indicate that transcripts encoding isoforms with the insertions are expressed in an adult-specific manner. Transcripts encoding four tandem repeats are also expressed in an adult-specific manner, whereas mRNAs encoding three tandem repeats are expressed throughout life, including in fetal brain. The levels of transcripts encoding the 29 or 58 amino acid inserts were not significantly changed in cerebral cortex from patients with Alzheimer's disease. Antisera raised against synthetic peptides corresponding to these different human tau isoforms demonstrate that multiple tau protein isoforms are incorporated into the neurofibrillary tangles of Alzheimer's disease.
journal_name
Neuronjournal_title
Neuronauthors
Goedert M,Spillantini MG,Jakes R,Rutherford D,Crowther RAdoi
10.1016/0896-6273(89)90210-9subject
Has Abstractpub_date
1989-10-01 00:00:00pages
519-26issue
4eissn
0896-6273issn
1097-4199pii
0896-6273(89)90210-9journal_volume
3pub_type
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