Abstract：
:Ultrasound has received widespread attention as an emerging technology for targeted, non-invasive neuromodulation based on its ability to evoke electrophysiological and motor responses in animals. However, little is known about the spatiotemporal pattern of ultrasound-induced brain activity that could drive these responses. Here, we address this question by combining focused ultrasound with wide-field optical imaging of calcium signals in transgenic mice. Surprisingly, we find cortical activity patterns consistent with indirect activation of auditory pathways rather than direct neuromodulation at the ultrasound focus. Ultrasound-induced activity is similar to that evoked by audible sound. Furthermore, both ultrasound and audible sound elicit motor responses consistent with a startle reflex, with both responses reduced by chemical deafening. These findings reveal an indirect auditory mechanism for ultrasound-induced cortical activity and movement requiring careful consideration in future development of ultrasonic neuromodulation as a tool in neuroscience research.
journal_name
Neuronjournal_title
Neuronauthors
Sato T,Shapiro MG,Tsao DYdoi
10.1016/j.neuron.2018.05.009subject
Has Abstractpub_date
2018-06-06 00:00:00pages
1031-1041.e5issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(18)30381-7journal_volume
98pub_type
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