Abstract：
:Nervous system injury and disease have broad effects on the functional connectivity of the nervous system, but how injury signals are spread across neural circuits remains unclear. We explored how axotomy changes the physiology of severed axons and adjacent uninjured "bystander" neurons in a simple in vivo nerve preparation. Within hours after injury, we observed suppression of axon transport in all axons, whether injured or not, and decreased mechano- and chemosensory signal transduction in uninjured bystander neurons. Unexpectedly, we found the axon death molecule dSarm, but not its NAD+ hydrolase activity, was required cell autonomously for these early changes in neuronal cell biology in bystander neurons, as were the voltage-gated calcium channel Cacophony (Cac) and the mitogen-activated protein kinase (MAPK) signaling cascade. Bystander neurons functionally recovered at later time points, while severed axons degenerated via α/Armadillo/Toll-interleukin receptor homology domain (dSarm)/Axundead signaling, and independently of Cac/MAPK. Interestingly, suppression of bystander neuron function required Draper/MEGF10 signaling in glia, indicating glial cells spread injury signals and actively suppress bystander neuron function. Our work identifies a new role for dSarm and glia in suppression of bystander neuron function after injury and defines two genetically and temporally separable phases of dSarm signaling in the injured nervous system.
journal_name
Neuronjournal_title
Neuronauthors
Hsu JM,Kang Y,Corty MM,Mathieson D,Peters OM,Freeman MRdoi
10.1016/j.neuron.2020.11.012subject
Has Abstractpub_date
2020-12-02 00:00:00eissn
0896-6273issn
1097-4199pii
S0896-6273(20)30890-4pub_type
杂志文章相关文献
NEURON文献大全abstract：:Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.04.002
更新日期：2020-07-08 00:00:00
abstract：:Through specific intersubunit contacts, the four subunits of the nicotinic acetylcholine receptor assemble into an alpha 2 beta gamma delta pentamer. The specificity of subunit association leads to formation of proper ligand binding sites and to transport of assembled pentamers to the cell surface. To identify determi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90320-8
更新日期：1995-03-01 00:00:00
abstract：:Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for Alzheimer's disease and other tauopathies. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2014.06.004
更新日期：2014-06-18 00:00:00
abstract：:The inner ear's performance is greatly enhanced by an active process defined by four features: amplification, frequency selectivity, compressive nonlinearity, and spontaneous otoacoustic emission. These characteristics emerge naturally if the mechanoelectrical transduction process operates near a dynamical instability...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2008.07.012
更新日期：2008-08-28 00:00:00
abstract：:How primates perceive objects along with their detailed features remains a mystery. This ability to make fine visual discriminations depends upon a high-acuity analysis of spatial frequency (SF) along the visual hierarchy from V1 to inferotemporal cortex. By studying the transformation of SF across macaque parafoveal ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.03.009
更新日期：2018-04-18 00:00:00
abstract：:The entire length of myelinated axons is organized into a series of polarized domains that center around nodes of Ranvier. These domains, which are crucial for normal saltatory conduction, consist of distinct multiprotein complexes of cell adhesion molecules, ion channels, and scaffolding molecules; they also differ i...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(03)00628-7
更新日期：2003-10-09 00:00:00
abstract：:Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.09.025
更新日期：2018-11-21 00:00:00
abstract：:Circadian rhythms are entrained to the natural day:night cycle. Melanopsin expressed in retinal ganglion cells partially accounts for circadian photoentrainment. Dkhissi-Benyahya et al. demonstrate that medium wavelength opsin (MW-opsin) also plays an important role in the process. Furthermore, they develop a model ex...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2007.02.017
更新日期：2007-03-01 00:00:00
abstract：:Cued spatial attention differentially modulates alpha power in attended relative to non-attended brain representations, termed the alpha asymmetry. Yet a causal role for alpha in attention is debated. In this issue of Neuron, Bagherzadeh et al., (2019) utilize neurofeedback to train alpha asymmetry and causally impact...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2019.12.033
更新日期：2020-02-05 00:00:00
abstract：:Cognitive theory posits association by juxtaposition or by fusion. We employed the measurement of event-related brain potentials (ERPs) to a concept fusion task in order to explore memory encoding of these two types of associations between word pairs, followed by a memory test for original pair order. Encoding process...
journal_title：Neuron
pub_type： 临床试验,杂志文章
doi：10.1016/s0896-6273(01)00199-4
更新日期：2001-01-01 00:00:00
abstract：:Convergent evidence suggests that corticostriatal interactions act as a gate to select the input to working memory (WM). However, not all information in WM is relevant for behavior simultaneously. For this reason, a second "output gate" might advantageously govern which contents of WM influence behavior. Here, we test...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.01.002
更新日期：2014-02-19 00:00:00
abstract：:The embryonic nervous system is refined over the course of development as a result of the twin processes of naturally occurring cell death and selective axon pruning. Recent studies provide new insights into the molecular events that underlie axon pruning and underscore the diversity of refinement processes employed b...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(03)00364-7
更新日期：2003-06-19 00:00:00
abstract：:A coculture system consisting of input axons from entorhinal cortex explants and target hippocampal pyramidal neurons was used to demonstrate that glutamate, released spontaneously from afferent axons, can influence both dendritic geometry of target neurons and formation of presumptive synaptic sites. Dendritic outgro...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(88)90134-1
更新日期：1988-11-01 00:00:00
abstract：:Declarative memories are thought to be stored within anatomically distributed neuronal networks requiring the hippocampus; however, it is unclear how neocortical areas participate in memory at the time of encoding. Here, we use a c-fos-based genetic tagging system to selectively express the channelrhodopsin variant, C...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.09.022
更新日期：2014-10-22 00:00:00
abstract：:In this issue of Neuron, Orbán et al. (2016) test whether the brain represents probabilities by sampling: do neurons interpret the world by generating causal explanations of sense data and quickly sample different interpretations over time? Orbán et al. (2016) find agreement between this model's predictions and neural...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.10.007
更新日期：2016-10-19 00:00:00
abstract：:Opiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the mu opioid receptor. A fundamental question in addiction biology is why exogenous opiate drugs have a high liability for inducing tolerance and addiction while native ligands do not. Studies indicate that highly addictive opiate d...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)80032-5
更新日期：1999-08-01 00:00:00
abstract：:Neuromodulators regulate circuits throughout the nervous system, and revealing the cell types and stimulus conditions controlling their release is vital to understanding their function. The effects of the neuromodulator nitric oxide (NO) have been studied in many circuits, including in the vertebrate retina, where it ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.09.047
更新日期：2018-12-05 00:00:00
abstract：:Flexible behavior in humans often requires that rapid choices be made between conflicting action plans. Although much attention has focused on prefrontal regions, little is understood about the contribution of parietal cortex under situations of response conflict. Here we show that right parietal damage associated wit...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.02.009
更新日期：2008-04-10 00:00:00
abstract：:Each residue in and flanking the M2 membrane-spanning segment of the alpha subunit, from Glu-241 to Glu-262, was mutated to cysteine, and the mutant subunits were expressed together with wild-type beta, gamma, and delta subunits in Xenopus oocytes. Cysteines substituted for Glu-262, Leu-258, Val-255, Ser-252, Leu-251,...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90257-7
更新日期：1994-10-01 00:00:00
abstract：:Immunophilins, including FK506-binding proteins (FKBPs), are protein chaperones with peptidyl-prolyl isomerase (PPIase) activity. Initially identified as pharmacological receptors for immunosuppressants to regulate immune responses via isomerase-independent mechanisms, FKBPs are most highly expressed in the nervous sy...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.09.025
更新日期：2009-11-25 00:00:00
abstract：:Early postnatal mammals, including human babies, can perform only basic motor tasks. The acquisition of skilled behaviors occurs later, requiring anatomical changes in neural circuitry to support the development of coordinated activation or suppression of functionally related muscle groups. How this circuit reorganiza...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.04.019
更新日期：2017-05-03 00:00:00
abstract：:The prefrontal cortex (PFC) and anterior cingulate cortex (ACC) have both been implicated in cognitive control, but their relative roles remain unclear. Here we recorded the activity of single neurons in both areas while monkeys performed a task that required them to switch between trials in which they had to look tow...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.12.023
更新日期：2007-02-01 00:00:00
abstract：:The anterior insular cortex (AIC) and its unique spindle-shaped von Economo neuron (VEN) emerged within the last decade as having a potentially major role in self-awareness and social cognition in humans. Invasive examination of the VEN has been precluded so far by the assumption that this neuron occurs among primates...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.03.003
更新日期：2012-05-10 00:00:00
abstract：:Neuroanatomical and functional asymmetries are universal features of the vertebrate CNS, but how asymmetry is generated is unknown. Here we show that zebrafish fgf8 mutants do not elaborate forebrain asymmetries, demonstrated by the failure of the parapineal nucleus to migrate from its initial midline position to the ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.11.030
更新日期：2009-01-15 00:00:00
abstract：:Sequential neural activity patterns are as ubiquitous as the outputs they drive, which include motor gestures and sequential cognitive processes. Neural sequences are long, compared to the activation durations of participating neurons, and sequence coding is sparse. Numerous studies demonstrate that spike-time-depende...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.02.003
更新日期：2010-02-25 00:00:00
abstract：:Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.12.006
更新日期：2010-01-14 00:00:00
abstract：:We have purified and characterized a factor, from the conditioned medium of neural stem cell cultures, which is required for fibroblast growth factor 2's (FGF-2) mitogenic activity on neural stem cells. This autocrine/paracrine cofactor is a glycosylated form of cystatin C (CCg), whose N-glycosylation is required for ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)00119-7
更新日期：2000-11-01 00:00:00
abstract：:Cognitive deficits, core features of mental illness, largely result from dysfunction of prefrontal networks. This dysfunction emerges during early development, before a detectable behavioral readout, yet the cellular elements controlling the abnormal maturation are still unknown. Here, we address this open question by...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.09.042
更新日期：2020-01-08 00:00:00
abstract：:The parietal lobes of nonhuman primates have been well characterized by single neuron recordings, yet clear partitioning of the human parietal lobes has not been clearly demonstrated. An elegant new fMRI study by Simon and colleagues (this issue of Neuron) suggests that parietal cortex does indeed contain dissociable ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/s0896-6273(02)00584-6
更新日期：2002-01-31 00:00:00
abstract：:Neuroligins (NLs) are critical for synapse formation and function. NL3 R451C is an autism-associated mutation. NL3 R451C knockin (KI) mice exhibit autistic behavioral abnormalities, including social novelty deficits. However, neither the brain regions involved in social novelty nor the underlying mechanisms are clearl...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.02.001
更新日期：2018-03-21 00:00:00
