Trajectory encoding in the hippocampus and entorhinal cortex.

abstract：:The visual cortex represents stimuli through the activity of neuronal populations. We measured the evolution of this activity in space and time by imaging voltage-sensitive dyes in cat area V1. Contrast-reversing stimuli elicit responses that oscillate at twice the stimulus frequency, indicating that signals originate...

journal_title：Neuron

authors： Benucci A,Frazor RA,Carandini M

更新日期：2007-07-05 00:00:00

abstract：:The rhodopsin regulatory protein, visual arrestin, undergoes light-dependent trafficking in mammalian and Drosophila photoreceptor cells, though the mechanisms underlying these movements are poorly understood. In Drosophila, the movement of the visual arrestin, Arr2, functions in long-term adaptation and is dependent ...

journal_title：Neuron

authors： Lee SJ,Montell C

更新日期：2004-07-08 00:00:00

abstract：:Trk tyrosine kinases are receptors for members of the neurotrophin family and are crucial for growth and survival of specific populations of neurons. Yet, the functions of neurotrophin-Trk signaling in postnatal development as well as maintenance and plasticity of the adult nervous system are less clear. We report her...

journal_title：Neuron

authors： Chen X,Ye H,Kuruvilla R,Ramanan N,Scangos KW,Zhang C,Johnson NM,England PM,Shokat KM,Ginty DD

更新日期：2005-04-07 00:00:00

abstract：:Cortical development depends on the active integration of cell-autonomous and extrinsic cues, but the coordination of these processes is poorly understood. Here, we show that the apical complex protein Pals1 and Pten have opposing roles in localizing the Igf1R to the apical, ventricular domain of cerebral cortical pro...

journal_title：Neuron

authors： Lehtinen MK,Zappaterra MW,Chen X,Yang YJ,Hill AD,Lun M,Maynard T,Gonzalez D,Kim S,Ye P,D'Ercole AJ,Wong ET,LaMantia AS,Walsh CA

更新日期：2011-03-10 00:00:00

abstract：:Phorbol esters and purified protein kinase C (PKC) have been shown to down-modulate the voltage-dependent Na+ channels expressed in Xenopus oocytes injected with chick brain RNA. We used the two-electrode voltage-clamp technique to demonstrate that a Na+ channel expressed in oocytes injected with RNA coding for the al...

journal_title：Neuron

authors： Dascal N,Lotan I

更新日期：1991-01-01 00:00:00

abstract：:Reversible silencing of neuronal activity is a powerful approach for isolating the roles of specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal excitation, for which the majority of studies have used a limited number of optogenetic and chemogenetic tools, the number of genetically...

journal_title：Neuron

authors： Wiegert JS,Mahn M,Prigge M,Printz Y,Yizhar O

更新日期：2017-08-02 00:00:00

abstract：:In a complex nervous system, neuronal functional diversity is reflected in the wide variety of dendritic arbor shapes. Different neuronal classes are defined by class-specific transcription factor combinatorial codes. We show that the combination of the transcription factors Knot and Cut is particular to Drosophila cl...

journal_title：Neuron

authors： Jinushi-Nakao S,Arvind R,Amikura R,Kinameri E,Liu AW,Moore AW

更新日期：2007-12-20 00:00:00

abstract：:Functionally distinct types of neurons develop in stereotypical positions in the vertebrate spinal cord. The mechanisms that generate this diversity have been well studied in the ventral and intermediate regions of the spinal cord, while dorsal cells have received less attention. In this issue of Neuron, two papers fo...

journal_title：Neuron

authors： Matise M

更新日期：2002-05-16 00:00:00

abstract：:Acetylcholinesterase (AChE) is concentrated at the vertebrate neuromuscular synapse. To determine whether increased transcript levels could underlie this selective accumulation, we employed a quantitative reverse transcription polymerase chain reaction-based assay to determine mRNA copy number in samples as small as s...

journal_title：Neuron

authors： Jasmin BJ,Lee RK,Rotundo RL

更新日期：1993-09-01 00:00:00

abstract：:Light-induced photoreceptor apoptosis occurs in many forms of inherited retinal degeneration resulting in blindness in both vertebrates and invertebrates. Though mutations in several photoreceptor signaling proteins have been implicated in triggering this process, the molecular events relating light activation of rhod...

journal_title：Neuron

authors： Kiselev A,Socolich M,Vinós J,Hardy RW,Zuker CS,Ranganathan R

更新日期：2000-10-01 00:00:00

abstract：:Here we describe the properties of a synapse in the Drosophila antennal lobe and show how they can explain certain sensory computations in this brain region. The synapse between olfactory receptor neurons (ORNs) and projection neurons (PNs) is very strong, reflecting a large number of release sites and high release pr...

journal_title：Neuron

authors： Kazama H,Wilson RI

更新日期：2008-05-08 00:00:00

abstract：:The ability of perisynaptic glial cells to modulate transmitter release and synaptic depression was studied at the frog neuromuscular junction (nmj). Injection of GTPgammaS in perisynaptic Schwann cells (PSCs), glial cells at this synapse, induced a reduction in the amplitude of nerve-evoked synaptic responses but had...

journal_title：Neuron

authors： Robitaille R

更新日期：1998-10-01 00:00:00

abstract：:Our understanding of the mechanisms whereby BACE1, the aspartyl protease required for the initial cleavage of APP to generate amyloid-beta (Abeta), is regulated in Alzheimer's disease (AD) remains incomplete. In this issue of Neuron, O'Connor and coworkers show how energy deprivation, a potential risk factor in AD, tr...

journal_title：Neuron

authors： Wong PC

更新日期：2008-12-26 00:00:00

abstract：:What underlies the large variation in mEPSC amplitude in the auditory system? And is this variability important? In this issue of Neuron, Li et al. (2014) address the significance of large mEPSCs to auditory processing and Chapochnikov et al. (2014) describe a novel mechanism underlying them. ...

journal_title：Neuron

authors： Lv C,Zenisek D

更新日期：2014-09-17 00:00:00

abstract：:We present a modular approach for analyzing calcium imaging recordings of large neuronal ensembles. Our goal is to simultaneously identify the locations of the neurons, demix spatially overlapping components, and denoise and deconvolve the spiking activity from the slow dynamics of the calcium indicator. Our approach ...

journal_title：Neuron

authors： Pnevmatikakis EA,Soudry D,Gao Y,Machado TA,Merel J,Pfau D,Reardon T,Mu Y,Lacefield C,Yang W,Ahrens M,Bruno R,Jessell TM,Peterka DS,Yuste R,Paninski L

更新日期：2016-01-20 00:00:00

abstract：:To investigate the role of the pathogenic prion protein (PrP(Sc)) in controlling susceptibility to foreign prions, two Syrian hamster (SHa) prion strains, Sc237 and DY, were transmitted to transgenic mice expressing chimeric SHa/mouse PrP genes, Tg(MH2M). First passage of SHa(Sc237) prions exhibited prolonged incubati...

journal_title：Neuron

authors： Peretz D,Williamson RA,Legname G,Matsunaga Y,Vergara J,Burton DR,DeArmond SJ,Prusiner SB,Scott MR

更新日期：2002-06-13 00:00:00

abstract：:Presynaptic CaV2 channels are essential for Ca2+-triggered exocytosis. In addition, there are two competing models for their roles in synapse structure. First, Ca2+ channels or Ca2+ entry may control synapse assembly. Second, active zone proteins may scaffold CaV2s to presynaptic release sites, and synapse structure i...

journal_title：Neuron

authors： Held RG,Liu C,Ma K,Ramsey AM,Tarr TB,De Nola G,Wang SSH,Wang J,van den Maagdenberg AMJM,Schneider T,Sun J,Blanpied TA,Kaeser PS

更新日期：2020-08-19 00:00:00

abstract：:Direction-selective ganglion cells (DSGCs) are tuned to motion in one direction. Starburst amacrine cells (SACs) are thought to mediate this direction selectivity through precise anatomical wiring to DSGCs. Nevertheless, we previously found that visual adaptation can reverse DSGCs's directional tuning, overcoming the ...

journal_title：Neuron

authors： Vlasits AL,Bos R,Morrie RD,Fortuny C,Flannery JG,Feller MB,Rivlin-Etzion M

更新日期：2014-09-03 00:00:00

abstract：:Historical milestones in neuroscience have come in diverse forms, ranging from the resolution of specific biological mysteries via creative experimentation to broad technological advances allowing neuroscientists to ask new kinds of questions. The continuous development of tools is driven with a special necessity by t...

journal_title：Neuron

authors： Deisseroth K,Schnitzer MJ

更新日期：2013-10-30 00:00:00

abstract：:Perceptual decisions require the transformation of raw sensory inputs into cortical representations suitable for stimulus discrimination. One of the best-known examples of this transformation involves the middle temporal area (MT) of the primate visual cortex. Area MT provides a robust representation of stimulus motio...

journal_title：Neuron

authors： Liu LD,Pack CC

更新日期：2017-07-19 00:00:00

abstract：:AMPA receptors are thought to be a tetrameric assembly of the subunits GluR1-4. We have examined whether two coexpressed subunits (GluR1/2) combine at random to form channels, or preferentially assemble with a specific stoichiometry and spatial configuration. The subunits carried markers controlling ion permeation and...

journal_title：Neuron

authors： Mansour M,Nagarajan N,Nehring RB,Clements JD,Rosenmund C

更新日期：2001-12-06 00:00:00

abstract：:Apart from being a common feature of mental illness, auditory hallucinations provide an intriguing model for the study of internally generated sensory perceptions that are attributed to external sources. Until now, the knowledge about the cortical network that supports such hallucinations has been restricted by method...

journal_title：Neuron

authors： Dierks T,Linden DE,Jandl M,Formisano E,Goebel R,Lanfermann H,Singer W

更新日期：1999-03-01 00:00:00

abstract：:Auditory information critical for fear conditioning, a model of emotional learning, is conveyed to the lateral nucleus of the amygdala via two routes: directly from the medial geniculate nucleus and indirectly from the auditory cortex. Here we show in the cortico-amygdala pathway that learned fear occludes electricall...

journal_title：Neuron

authors： Tsvetkov E,Carlezon WA,Benes FM,Kandel ER,Bolshakov VY

更新日期：2002-04-11 00:00:00

abstract：:A critical feature of neural networks is that they balance excitation and inhibition to prevent pathological dysfunction. How this is achieved is largely unknown, although deficits in the balance contribute to many neurological disorders. We show here that a microRNA (miR-101) is a key orchestrator of this essential f...

journal_title：Neuron

authors： Lippi G,Fernandes CC,Ewell LA,John D,Romoli B,Curia G,Taylor SR,Frady EP,Jensen AB,Liu JC,Chaabane MM,Belal C,Nathanson JL,Zoli M,Leutgeb JK,Biagini G,Yeo GW,Berg DK

更新日期：2016-12-21 00:00:00

abstract：:Na+ channels are present at high density in squid giant axon but are absent from its somata in the giant fiber lobe (GFL) of the stellate ganglion. GFL cells dispersed in vitro maintain growing axons and develop a Na+ channel distribution similar to that in vivo. Tunicamycin, a glycosylation inhibitor, selectively dis...

journal_title：Neuron

authors： Gilly WF,Lucero MT,Horrigan FT

更新日期：1990-11-01 00:00:00

abstract：:Motor units comprise a pre-synaptic motor neuron and multiple post-synaptic muscle fibers. Many movement disorders disrupt motor unit contractile dynamics and the structure of sarcomeres, skeletal muscle's contractile units. Despite the motor unit's centrality to neuromuscular physiology, no extant technology can imag...

journal_title：Neuron

authors： Sanchez GN,Sinha S,Liske H,Chen X,Nguyen V,Delp SL,Schnitzer MJ

更新日期：2015-12-16 00:00:00

abstract：:In addition to the classical, center/surround receptive field of neurons in the lateral geniculate nucleus (LGN), there is an extraclassical, nonlinear surround that can strongly suppress LGN responses. This form of suppression likely plays an important role in adjusting the gain of LGN responses to visual stimuli. We...

journal_title：Neuron

authors： Alitto HJ,Usrey WM

更新日期：2008-01-10 00:00:00

abstract：:Basal ganglia (BG) circuits orchestrate complex motor behaviors predominantly via inhibitory synaptic outputs. Although these inhibitory BG outputs are known to reduce the excitability of postsynaptic target neurons, precisely how this change impairs motor performance remains poorly understood. Here, we show that opto...

journal_title：Neuron

authors： Kim J,Kim Y,Nakajima R,Shin A,Jeong M,Park AH,Jeong Y,Jo S,Yang S,Park H,Cho SH,Cho KH,Shim I,Chung JH,Paik SB,Augustine GJ,Kim D

更新日期：2017-08-30 00:00:00

abstract：:Miniature synaptic currents have long been known to represent random transmitter release under resting conditions, but much remains to be learned about their nature and function in central synapses. In this work, we describe a new class of miniature currents ("preminis") that arise by the autocrine activation of axona...

journal_title：Neuron

authors： Trigo FF,Bouhours B,Rostaing P,Papageorgiou G,Corrie JE,Triller A,Ogden D,Marty A

更新日期：2010-04-29 00:00:00

abstract：:The molecular specification of central circuits that coordinate expression of innate behaviors in response to specific sensory cues from the environment remains a puzzle. In this issue of Neuron, Choi, Dong, and colleagues used expression profiling and genetic axonal tracing to visualize a hypothalamic point of conver...

journal_title：Neuron

authors： Simerly R

更新日期：2005-05-19 00:00:00