Abstract：
:Direction selectivity (DS) is an important neuronal property in the visual system, but how DS is generated beyond the retina remains controversial. Here, we report a close correspondence between the preferred direction (PD) and the morphology of DS cells in the optic tectum. Ca(2+) imaging in cells expressing the genetically encoded Ca(2+) indicator GCaMP3 and multiphoton-targeted patch-clamp recordings allowed us to compare structure and function in single neurons. The arbors of differently tuned cell types showed stereotypic differences in shape and laminar profile within the tectal neuropil. Excitatory synaptic inputs were directionally tuned and matched the PD of spike output in these cells, while inhibitory inputs were selective for nonpreferred directions. Functional Ca(2+) imaging in afferent axons showed a matching laminar distribution of DS presynaptic activity. Hence, different directions are represented in different layers, which suggests a simple mechanism for how tectal neurons acquire directional tuning in a nascent circuit.
journal_name
Neuronjournal_title
Neuronauthors
Gabriel JP,Trivedi CA,Maurer CM,Ryu S,Bollmann JHdoi
10.1016/j.neuron.2012.12.003subject
Has Abstractpub_date
2012-12-20 00:00:00pages
1147-60issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(12)01109-9journal_volume
76pub_type
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