Control of inhibitory synaptic outputs by low excitability of axon terminals revealed by direct recording.

Abstract:

:An axon is thought to faithfully conduct action potentials to its terminals. However, many features of the axon and axon terminals, especially at inhibitory synapses, remain unknown. By directly recording from the axon and terminal of a cultured cerebellar Purkinje cell (PC), we demonstrate that low membrane excitability of axon terminals shapes synaptic output. Simultaneous measurements of presynaptic capacitance and evoked IPSCs revealed PC axon terminals contained large readily releasable synaptic vesicles that exhibited a low release probability. Nevertheless, IPSCs evoked by stimulating a PC soma underwent frequency-dependent depression. Direct axonal recordings showed that high-frequency action potentials were faithfully conducted over axonal bifurcations but were attenuated around terminals. Sparse Na(+) channels relative to enriched voltage-gated K(+) channels in terminals caused short-term depression of IPSCs by reducing Ca(2+) influx. Together with confirmation in slice recordings, our findings reveal a presynaptic mechanism that shapes short-term synaptic depression without depleting releasable vesicles.

journal_name

Neuron

journal_title

Neuron

authors

Kawaguchi SY,Sakaba T

doi

10.1016/j.neuron.2015.02.013

subject

Has Abstract

pub_date

2015-03-18 00:00:00

pages

1273-88

issue

6

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(15)00102-6

journal_volume

85

pub_type

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