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A Novel Mechanism for the Grid-to-Place Cell Transformation Revealed by Transgenic Depolarization of Medial Entorhinal Cortex Layer II.

Abstract：

:The spatial receptive fields of neurons in medial entorhinal cortex layer II (MECII) and in the hippocampus suggest general and environment-specific maps of space, respectively. However, the relationship between these receptive fields remains unclear. We reversibly manipulated the activity of MECII neurons via chemogenetic receptors and compared the changes in downstream hippocampal place cells to those of neurons in MEC. Depolarization of MECII impaired spatial memory and elicited drastic changes in CA1 place cells in a familiar environment, similar to those seen during remapping between distinct environments, while hyperpolarization did not. In contrast, both manipulations altered the firing rate of MEC neurons without changing their firing locations. Interestingly, only depolarization caused significant changes in the relative firing rates of individual grid fields, reconfiguring the spatial input from MEC. This suggests a novel mechanism of hippocampal remapping whereby rate changes in MEC neurons lead to locational changes of hippocampal place fields.

journal_name

Neuron

journal_title

Neuron

authors

Kanter BR,Lykken CM,Avesar D,Weible A,Dickinson J,Dunn B,Borgesius NZ,Roudi Y,Kentros CG

doi

10.1016/j.neuron.2017.03.001

subject

Has Abstract

pub_date

2017-03-22 00:00:00

pages

1480-1492.e6

issue

6

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(17)30158-7

journal_volume

93

pub_type

杂志文章

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