Abstract：
:The serotonin system powerfully modulates physiology and behavior in health and disease, yet the circuit mechanisms underlying serotonin neuron activity are poorly understood. The major source of forebrain serotonergic innervation is from the dorsal raphe nucleus (DR), which contains both serotonin and GABA neurons. Using viral tracing combined with electrophysiology, we found that GABA and serotonin neurons in the DR receive excitatory, inhibitory, and peptidergic inputs from the same specific brain regions. Embedded in this overall similarity are important differences. Serotonin neurons are more likely to receive synaptic inputs from anterior neocortex while GABA neurons receive disproportionally higher input from the central amygdala. Local input mapping revealed extensive serotonin-serotonin as well as GABA-serotonin connectivity with a distinct spatial organization. Covariance analysis suggests heterogeneity of both serotonin and GABA neurons with respect to the inputs they receive. These analyses provide a foundation for further functional dissection of the serotonin system.
journal_name
Neuronjournal_title
Neuronauthors
Weissbourd B,Ren J,DeLoach KE,Guenthner CJ,Miyamichi K,Luo Ldoi
10.1016/j.neuron.2014.06.024subject
Has Abstractpub_date
2014-08-06 00:00:00pages
645-62issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(14)00546-7journal_volume
83pub_type
杂志文章相关文献
NEURON文献大全abstract：:Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar gra...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00200-9
更新日期：2003-05-08 00:00:00
abstract：:Molecular determinants of threshold sensitivity of mammalian mechanoreceptors are unknown. Here, we identify a mechanosensitive (MS) K(+) current (IKmech) that governs mechanical threshold and adaptation of distinct populations of mechanoreceptors. Toxin profiling and transgenic mouse studies indicate that IKmech is c...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.12.035
更新日期：2013-03-06 00:00:00
abstract：:Changes in the response to release of a single synaptic vesicle have generally been attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now demonstrates that alterations in vesicle filling also contribute to changes in quantal size. Receptors are not saturated at many synapses, a...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2007.09.001
更新日期：2007-09-20 00:00:00
abstract：:Myelin ensheathes axons to allow rapid propagation of action potentials and proper nervous system function. In the peripheral nervous system, Schwann cells (SCs) radially sort axons into a 1:1 relationship before wrapping an axonal segment to form myelin. SC myelination requires the adhesion G protein-coupled receptor...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.12.057
更新日期：2015-02-18 00:00:00
abstract：:A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.09.027
更新日期：2008-10-09 00:00:00
abstract：:Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields have been combined only recently to facilitate novel experiments and measurements in neuroscience. Since tissue-clearing methods were first combined with modernized light-sheet microscopy a decade ago, the performance of both tec...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2020.03.004
更新日期：2020-05-06 00:00:00
abstract：:When learning to achieve a goal through a complex series of actions, humans often group several actions into a subroutine and evaluate whether the subroutine achieved a specific subgoal. A new study reports brain responses consistent with such "hierarchical reinforcement learning." ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2011.07.004
更新日期：2011-07-28 00:00:00
abstract：:The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that early tau-related defic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.11.030
更新日期：2010-12-22 00:00:00
abstract：:Diphosphoinositol-pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate (InsP8) possess pyrophosphate bonds. InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified InsP6 kinases designated InsP6K1 and InsP6K2. We now report the identification, cloning, and characterization of a n...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00384-1
更新日期：2001-08-16 00:00:00
abstract：:How primates perceive objects along with their detailed features remains a mystery. This ability to make fine visual discriminations depends upon a high-acuity analysis of spatial frequency (SF) along the visual hierarchy from V1 to inferotemporal cortex. By studying the transformation of SF across macaque parafoveal ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.03.009
更新日期：2018-04-18 00:00:00
abstract：:The carboxyl terminus of presenilin 1 and 2 (PS1 and PS2) binds to the neuron-specific cell adhesion molecule telencephalin (TLN) in the brain. PS1 deficiency results in the abnormal accumulation of TLN in a yet unidentified intracellular compartment. The first transmembrane domain and carboxyl terminus of PS1 form a ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00512-8
更新日期：2001-11-20 00:00:00
abstract：:Light-evoked responses of all three major classes of retinal ganglion cells (RGCs) are mediated by NMDA receptors (NMDARs) and AMPA receptors (AMPARs). Although synaptic activity at RGC synapses is highly dynamic, synaptic plasticity has not been observed in adult RGCs. Here, using patch-clamp recordings in dark-adapt...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.05.030
更新日期：2012-08-09 00:00:00
abstract：:Many animals guide their movements using optic flow, the displacement of stationary objects across the retina caused by self-motion. How do animals selectively synthesize a global motion pattern from its local motion components? To what extent does this feature selectivity rely on circuit mechanisms versus dendritic p...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.08.022
更新日期：2018-10-10 00:00:00
abstract：:Neural synchronization plays an important role in information flow in the nervous system under healthy and pathological conditions. In this issue of Neuron, Gittis et al. show that reorganization of striatal microcircuits promotes synchronous activity and may underlie the pathological network oscillations at the root ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2011.08.012
更新日期：2011-09-08 00:00:00
abstract：:The parietal lobes of nonhuman primates have been well characterized by single neuron recordings, yet clear partitioning of the human parietal lobes has not been clearly demonstrated. An elegant new fMRI study by Simon and colleagues (this issue of Neuron) suggests that parietal cortex does indeed contain dissociable ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/s0896-6273(02)00584-6
更新日期：2002-01-31 00:00:00
abstract：:The Fragile X mental retardation protein (FMRP) regulates neuronal RNA metabolism, and its absence or mutations leads to the Fragile X syndrome (FXS). The β-amyloid precursor protein (APP) is involved in Alzheimer's disease, plays a role in synapse formation, and is upregulated in intellectual disabilities. Here, we s...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.06.032
更新日期：2015-07-15 00:00:00
abstract：:Serotonergic neurons are thought to play a role in depression and obsessive compulsive disorder. However, their functional transmitter repertoire is incompletely known. To investigate this repertoire, intracellular recordings were obtained from 132 cytochemically identified rat mesopontine serotonergic neurons that ha...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90283-6
更新日期：1994-02-01 00:00:00
abstract：:In this issue of Neuron, Kraus et al. (2013) show that a population of "time cells" in the hippocampus responds to the passage of time rather than simply reflecting path integration. This study advances our understanding of how time is represented in the hippocampus. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2013.05.039
更新日期：2013-06-19 00:00:00
abstract：:Olfactory receptor neurons (ORNs) are replaced and differentiate in adult animals, but differentiation in dissociated cell culture has not been demonstrated. To test whether contact with the CNS regulates maturation, neonatal rat olfactory cells were grown on a culture substrate or on CNS astrocytes. Mature ORNs, immu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90139-5
更新日期：1992-06-01 00:00:00
abstract：:The directional selectivity of retinal ganglion cell responses represents a primitive pattern recognition that operates within a retinal neural circuit. The cellular origin and mechanism of directional selectivity were investigated by selectively eliminating retinal starburst amacrine cells, using immunotoxin-mediated...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00316-6
更新日期：2001-06-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the P362L mutation in the low-complexity domain (LCD) of T cell-rest...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.07.025
更新日期：2017-08-16 00:00:00
abstract：:For each environment a rodent has explored, its hippocampus contains a map consisting of a unique subset of neurons, called place cells, that have spatially tuned spiking there, with the remaining neurons being essentially silent. Using whole-cell recording in freely moving rats exploring a novel maze, we observed dif...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.03.006
更新日期：2011-04-14 00:00:00
abstract：:Pheromonal activation of the vomeronasal organ (VNO) elicits genetically preprogrammed behaviors and physiological changes in mammals. We have identified a novel gene family encoding over one hundred VNO specific receptors, the V3Rs. V3R sequences are highly similar to each other and appear distantly related to the pu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)00157-4
更新日期：2000-12-01 00:00:00
abstract：:Memories are about the past, but they serve the future. Memory research often emphasizes the former aspect: focusing on the functions that re-constitute (re-member) experience and elucidating the various types of memories and their interrelations, timescales, and neural bases. Here we highlight the prospective nature ...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2019.08.030
更新日期：2019-10-09 00:00:00
abstract：:Presynaptic neurexins (Nrxs) and type IIa receptor-type protein tyrosine phosphatases (RPTPs) organize synapses through a network of postsynaptic ligands. We show that leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) differentially engage the protein domains of Nrx but require its heparan sulfate (HS) modi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.01.003
更新日期：2020-04-08 00:00:00
abstract：:Nociceptin opioid peptide receptor agonists interact with mu-opioid receptor agonists for pain relief. A new study by Ding et al. (2018) examines a bifunctional nociceptin- and mu-opioid receptor agonist, AT-121, that provides analgesia without physiological side effects or abuse liability, offering a promising new ho...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2018.11.045
更新日期：2018-12-19 00:00:00
abstract：:Insulin-like growth factor I (IGF-I) is a potent regulator of oligodendrocyte development and myelination in vitro, but its effect on myelination in vivo has never been tested directly. Therefore, we examined brain growth and myelination in a transgenic mouse line that overexpresses IGF-I. By postnatal day 55, when br...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90173-o
更新日期：1993-04-01 00:00:00
abstract：:The location, size, and number of synapses critically influence the specificity and strength of neural connections. In axons, synaptic vesicle (SV) and active zone (AZ) proteins are transported by molecular motors and accumulate at discrete presynaptic loci. Little is known about the mechanisms coordinating presynapti...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.04.035
更新日期：2013-06-19 00:00:00
abstract：:Serotonin, a neuromodulator at the crayfish neuromuscular junction, regulates neurotransmission without changing intracellular calcium levels. However, the mechanism of this regulation remains unclear. By analysis of synaptic depression using a depletion model and measurement of vesicle recycling using the styryl dye ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80523-1
更新日期：1998-07-01 00:00:00
abstract：:Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m6A/m RNA modifications in the adult mammalian brain in regulating physiolog...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.07.019
更新日期：2018-07-25 00:00:00
