Abstract：
:Na+ channels are present at high density in squid giant axon but are absent from its somata in the giant fiber lobe (GFL) of the stellate ganglion. GFL cells dispersed in vitro maintain growing axons and develop a Na+ channel distribution similar to that in vivo. Tunicamycin, a glycosylation inhibitor, selectively disrupts the spatially appropriate, high level expression of Na+ channels in axonal membrane but has no effect on expression in cell bodies, which show low level, inappropriate expression in vitro. This effect does not appear to involve alteration in Na+ channel turnover or axon viability. K+ channel distribution is unaffected. Thus, glycosylation appears to be involved in controlling Na+ channel localization in squid neurons.
journal_name
Neuronjournal_title
Neuronauthors
Gilly WF,Lucero MT,Horrigan FTdoi
10.1016/0896-6273(90)90220-asubject
Has Abstractpub_date
1990-11-01 00:00:00pages
663-74issue
5eissn
0896-6273issn
1097-4199pii
0896-6273(90)90220-Ajournal_volume
5pub_type
杂志文章相关文献
NEURON文献大全abstract：:We have used the caged calcium compound DM-nitrophen to investigate the kinetics of calcium-dependent secretion in bovine chromaffin cells. Perfusion with partially calcium-loaded nitrophen often caused a loading transient--slow secretion for up to 1 min due to displacement of Ca2+ by cytoplasmic Mg2+. Flash photolysi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90238-m
更新日期：1993-01-01 00:00:00
abstract：:Modification of AMPA receptor function is a major mechanism for the regulation of synaptic transmission and underlies several forms of synaptic plasticity. Post-translational palmitoylation is a reversible modification that regulates localization of many proteins. Here, we report that palmitoylation of the AMPA recept...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.06.035
更新日期：2005-09-01 00:00:00
abstract：:Light-evoked responses of all three major classes of retinal ganglion cells (RGCs) are mediated by NMDA receptors (NMDARs) and AMPA receptors (AMPARs). Although synaptic activity at RGC synapses is highly dynamic, synaptic plasticity has not been observed in adult RGCs. Here, using patch-clamp recordings in dark-adapt...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.05.030
更新日期：2012-08-09 00:00:00
abstract：:Classical studies have related the spiking of selected neocortical neurons to behavior, but little is known about activity sampled from the entire neural population. We recorded from neurons selected independent of spiking, using cell-attached recordings and two-photon calcium imaging, in the barrel cortex of mice per...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.08.026
更新日期：2010-09-23 00:00:00
abstract：:Neuronal motor commands, whether generating real or neuroprosthetic movements, are shaped by ongoing sensory feedback from the displacement being produced. Here we asked if cortical stimulation could provide artificial feedback during operant conditioning of cortical neurons. Simultaneous two-photon imaging and real-t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.01.023
更新日期：2017-02-22 00:00:00
abstract：:Self-consciousness has mostly been approached by philosophical enquiry and not by empirical neuroscientific study, leading to an overabundance of diverging theories and an absence of data-driven theories. Using robotic technology, we achieved specific bodily conflicts and induced predictable changes in a fundamental a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.03.009
更新日期：2011-04-28 00:00:00
abstract：:The relative timing of presynaptic and postsynaptic spikes plays a critical role in activity-induced synaptic modification. Here we examined whether plasticity of orientation selectivity in the visual cortex depends on stimulus timing. Repetitive pairing of visual stimuli at two orientations induced a shift in orienta...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00460-3
更新日期：2001-10-25 00:00:00
abstract：:In stable environments, decision makers can exploit their previously learned strategies for optimal outcomes, while exploration might lead to better options in unstable environments. Here, to investigate the cortical contributions to exploratory behavior, we analyzed single-neuron activity recorded from four different...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.07.040
更新日期：2013-10-02 00:00:00
abstract：:Functional neuroimaging uses activity-dependent changes in cerebral blood flow to map brain activity, but the contributions of presynaptic and postsynaptic activity are incompletely understood, as are the underlying cellular pathways. Using intravital multiphoton microscopy, we measured presynaptic activity, postsynap...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.04.029
更新日期：2008-06-26 00:00:00
abstract：:Mammalian olfactory sensory neurons that express a particular odorant receptor (OR) project axons to the same few glomeruli in the olfactory bulb. In this issue of Neuron, Vassalli et al. use OR minigenes that coexpress histochemical markers and show that the determinants in the sensory neurons required to generate th...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(02)00831-0
更新日期：2002-08-15 00:00:00
abstract：:AMPA but not kainate produces a rapidly desensitizing response in mouse hippocampal neurons. The characteristic action of these agonists appears to arise from activation of a single receptor with active and desensitized states, for which AMPA and kainate have different relative affinity. The equilibrium potency of a s...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(91)90175-y
更新日期：1991-05-01 00:00:00
abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key modulators of neuronal activity by providing the depolarizing cation current I(h) involved in rhythmogenesis, dendritic integration, and synaptic transmission. These tasks critically depend on the availability of HCN channels, which is dynamica...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.05.008
更新日期：2009-06-25 00:00:00
abstract：:Neurotrophins and tyrosine receptor kinase (Trk) receptors are expressed in skeletal muscle, but it is unclear what functional role Trk-mediated signaling plays during postnatal life. Full-length TrkB (trkB.FL) as well as truncated TrkB (trkB.t1) were found to be localized primarily to the postsynaptic acetylcholine r...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81113-7
更新日期：1999-11-01 00:00:00
abstract：:How primates perceive objects along with their detailed features remains a mystery. This ability to make fine visual discriminations depends upon a high-acuity analysis of spatial frequency (SF) along the visual hierarchy from V1 to inferotemporal cortex. By studying the transformation of SF across macaque parafoveal ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.03.009
更新日期：2018-04-18 00:00:00
abstract：:In rodents, each main olfactory bulb contains two mirror-symmetric glomerular maps, a feature not found in the initial topographic maps of other sensory systems. Targeting tracer injections to identified glomeruli revealed that isofunctional odor columns-translaminar assemblies connected to a given glomerulus-were spe...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00194-6
更新日期：2003-04-24 00:00:00
abstract：:To assess the necessary parameters for the growth of axons within the adult rat CNS, we have used intracerebral grafts of primary fibroblasts genetically engineered to express nerve growth factor (NGF). Following the implantation of NGF-producing primary fibroblasts within the striatum, cholinergic axons arising from ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(91)90346-2
更新日期：1991-12-01 00:00:00
abstract：:Since the early days of research into language and the brain, word meaning was assumed to be processed in specific brain regions, which most modern neuroscientists localize to the left temporal lobe. Here we use event-related fMRI to show that action words referring to face, arm, or leg actions (e.g., to lick, pick, o...
journal_title：Neuron
pub_type： 临床试验,杂志文章
doi：10.1016/s0896-6273(03)00838-9
更新日期：2004-01-22 00:00:00
abstract：:Secretion principles are conserved from yeast to humans, and many yeast orthologs have established roles in synaptic vesicle exocytosis in the mammalian brain. Surprisingly, SEC4 orthologs and their effectors, the exocyst, are dispensable for synaptic vesicle exocytosis. Here, we identify the SEC4 ortholog RAB3 and it...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.09.015
更新日期：2019-12-18 00:00:00
abstract：:A coculture system consisting of input axons from entorhinal cortex explants and target hippocampal pyramidal neurons was used to demonstrate that glutamate, released spontaneously from afferent axons, can influence both dendritic geometry of target neurons and formation of presumptive synaptic sites. Dendritic outgro...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(88)90134-1
更新日期：1988-11-01 00:00:00
abstract：:A male zebra finch learns a song by listening to a tutor, but song learning is normally restricted to a critical period in juvenile development. Here we identify an RNA whose expression in the song control circuit is altered during this critical period. The RNA encodes a soluble presynaptic protein that forms a predic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90040-3
更新日期：1995-08-01 00:00:00
abstract：:Loss-of-function mutations in the parkin gene, which encodes an E3 ubiquitin ligase, are the major cause of early-onset Parkinson's disease (PD). In this issue of Neuron, Kalia et al. show that the bcl-2-associated athanogene 5 (BAG5) enhances dopamine neuron death in an in vivo model of PD through inhibiting the E3 l...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2004.12.007
更新日期：2004-12-16 00:00:00
abstract：:Leukemia inhibitory factor (LIF) is a cytokine that affects the survival and differentiation of certain neuronal populations in vitro. To identify LIF-responsive neurons in the adult rat, we have demonstrated retrograde axonal transport of 125I-LIF to sensory and motor neurons. The accumulation of 125I-LIF by both cel...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90163-5
更新日期：1994-01-01 00:00:00
abstract：:Many activity-dependent changes in synaptic efficacy occur through elevations in postsynaptic calcium triggered by glutamate receptor activation. Here, the postsynaptic, neuron-specific microtubule-associated protein MAP2 is identified as a target of bidirectional calcium-dependent signaling pathways activated by glut...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80053-7
更新日期：1996-02-01 00:00:00
abstract：:The Drosophila circadian oscillator consists of interlocked period (per)/timeless (tim) and Clock (Clk) transcriptional/translational feedback loops. Within these feedback loops, CLK and CYCLE (CYC) activate per and tim transcription at the same time as they repress Clk transcription, thus controlling the opposite cyc...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00002-3
更新日期：2003-01-23 00:00:00
abstract：:During the metamorphosis of the Xenopus laevis retina, thyroid hormone (TH) preferentially induces ventral ciliary marginal zone (CMZ) cells to both increase their proliferation and give rise to ipsilaterally projecting ganglion cells. Here we show that dorsal CMZ cells express type III deiodinase (D3), an enzyme that...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81034-x
更新日期：1999-12-01 00:00:00
abstract：:Grid cells in medial entorhinal cortex (MEC) can be modeled using oscillatory interference or attractor dynamic mechanisms that perform path integration, a computation requiring information about running direction and speed. The two classes of computational models often use either an oscillatory frequency or a firing ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.06.027
更新日期：2016-08-03 00:00:00
abstract：:Recent work has suggested a link between h channels and epilepsy. In this issue of Neuron, Shah et al. demonstrate that a robust, postseizure decrease in h channels during a critical phase of epileptogenesis mechanistically underlies dendritic hyperexcitability in entorhinal-hippocampal pyramidal cells. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.10.018
更新日期：2004-10-28 00:00:00
abstract：:The visual cortex has the capacity for experience-dependent change, or cortical plasticity, that is retained throughout life. Plasticity is invoked for encoding information during perceptual learning, by internally representing the regularities of the visual environment, which is useful for facilitating intermediate-l...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.06.030
更新日期：2012-07-26 00:00:00
abstract：:Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.04.002
更新日期：2020-07-08 00:00:00
abstract：:The Neurodata Without Borders (NWB) initiative promotes data standardization in neuroscience to increase research reproducibility and opportunities. In the first NWB pilot project, neurophysiologists and software developers produced a common data format for recordings and metadata of cellular electrophysiology and opt...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.10.025
更新日期：2015-11-18 00:00:00
