Inactivity sets XL synapses in motion.

abstract：:In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP)...

journal_title：Neuron

authors： Dragoi G,Harris KD,Buzsáki G

更新日期：2003-08-28 00:00:00

abstract：:Prime diagnostic criteria for drug addiction include uncontrollable urges to obtain drugs and reduced behavioral responding for natural rewards. Cellular adaptations in the glutamate projection from the prefrontal cortex (PFC) to the nucleus accumbens have been discovered in rats withdrawn from cocaine that may underl...

journal_title：Neuron

authors： Kalivas PW,Volkow N,Seamans J

更新日期：2005-03-03 00:00:00

abstract：:Autism spectrum disorder (ASD) may arise from increased ratio of excitatory to inhibitory neurotransmission in the brain. Many pharmacological treatments have been tested in ASD, but only limited success has been achieved. Here we report that BTBR T(+)Itpr3(tf)/J (BTBR) mice, a model of idiopathic autism, have reduced...

journal_title：Neuron

authors： Han S,Tai C,Jones CJ,Scheuer T,Catterall WA

更新日期：2014-03-19 00:00:00

abstract：:The ability of a neuronal surface glycoprotein to mediate the formation of neuronal connections was tested in an explant culture system. A monoclonal antibody against the limbic system-associated membrane protein (LAMP) was used in co-cultures containing cholinergic neurons of the septum and their hippocampal target n...

journal_title：Neuron

authors： Keller F,Rimvall K,Barbe MF,Levitt P

更新日期：1989-11-01 00:00:00

abstract：:The serotonin system powerfully modulates physiology and behavior in health and disease, yet the circuit mechanisms underlying serotonin neuron activity are poorly understood. The major source of forebrain serotonergic innervation is from the dorsal raphe nucleus (DR), which contains both serotonin and GABA neurons. U...

journal_title：Neuron

authors： Weissbourd B,Ren J,DeLoach KE,Guenthner CJ,Miyamichi K,Luo L

更新日期：2014-08-06 00:00:00

abstract：:Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions...

journal_title：Neuron

authors： Maruyama M,Shimada H,Suhara T,Shinotoh H,Ji B,Maeda J,Zhang MR,Trojanowski JQ,Lee VM,Ono M,Masamoto K,Takano H,Sahara N,Iwata N,Okamura N,Furumoto S,Kudo Y,Chang Q,Saido TC,Takashima A,Lewis J,Jang MK,Aoki I,

更新日期：2013-09-18 00:00:00

abstract：:Aβ Immunotherapy is a promising therapeutic approach for Alzheimer's disease. Preclinical studies demonstrate that plaque prevention is possible; however, the more relevant therapeutic removal of existing plaque has proven elusive. Monoclonal antibodies in development target both soluble and insoluble Aβ peptide. We h...

journal_title：Neuron

authors： Demattos RB,Lu J,Tang Y,Racke MM,Delong CA,Tzaferis JA,Hole JT,Forster BM,McDonnell PC,Liu F,Kinley RD,Jordan WH,Hutton ML

更新日期：2012-12-06 00:00:00

abstract：:We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR5(2b,) GluR5(2c), and GluR6. Of these, we show that both GRIP and PICK1 interactions are required to maintain KAR-mediated synaptic function at mossy fiber-CA3 synapses. In a...

journal_title：Neuron

authors： Hirbec H,Francis JC,Lauri SE,Braithwaite SP,Coussen F,Mulle C,Dev KK,Coutinho V,Meyer G,Isaac JT,Collingridge GL,Henley JM

更新日期：2003-02-20 00:00:00

abstract：:Yang et al. (2016) show that transplantation of GABAergic inhibitory neurons into the amygdala boosts the persistence of fear extinction in mice. Transplantation was found to degrade perineuronal nets on endogenous inhibitory neurons and enhance synaptic plasticity in host amygdala. ...

journal_title：Neuron

authors： Zheng X,Gandhi SP

更新日期：2016-12-21 00:00:00

abstract：:Circadian pacemaker neurons contain a molecular clock that oscillates with a period of approximately 24 hr, controlling circadian rhythms of behavior. Pacemaker neurons respond to visual system inputs for clock resetting, but, unlike other neurons, have not been reported to transmit rapid signals to their targets. Her...

journal_title：Neuron

authors： Mazzoni EO,Desplan C,Blau J

更新日期：2005-01-20 00:00:00

abstract：:Miniature synaptic currents have long been known to represent random transmitter release under resting conditions, but much remains to be learned about their nature and function in central synapses. In this work, we describe a new class of miniature currents ("preminis") that arise by the autocrine activation of axona...

journal_title：Neuron

authors： Trigo FF,Bouhours B,Rostaing P,Papageorgiou G,Corrie JE,Triller A,Ogden D,Marty A

更新日期：2010-04-29 00:00:00

abstract：:A fundamental property of neuronal circuits is the ability to adapt to altered sensory inputs. It is well established that the functional synaptic changes underlying this adaptation are reflected by structural modifications in excitatory neurons. In contrast, the degree to which structural plasticity in inhibitory neu...

journal_title：Neuron

authors： Keck T,Scheuss V,Jacobsen RI,Wierenga CJ,Eysel UT,Bonhoeffer T,Hübener M

更新日期：2011-09-08 00:00:00

abstract：:Adjustments in neural activity can drive cortical plasticity, but the underlying circuit components remain unclear. In this issue of Neuron, Barnes et al. (2015) show that visual deprivation-induced homeostatic plasticity invokes specific changes among select categories of V1 neurons. ...

journal_title：Neuron

authors： Seabrook TA,Huberman AD

更新日期：2015-06-03 00:00:00

abstract：:Inflammatory mediators act on peripheral sensory neurons to produce pain and hypersensitivity after tissue injury. In this issue of Neuron, Dina et al. report that inflammatory mediators, such as epinephrine and prostaglandins, appear to couple to specific G protein-coupled receptor signaling pathways through plastic ...

journal_title：Neuron

authors： Bhave G,Gereau RW 4th

更新日期：2003-08-14 00:00:00

abstract：:In a complex nervous system, neuronal functional diversity is reflected in the wide variety of dendritic arbor shapes. Different neuronal classes are defined by class-specific transcription factor combinatorial codes. We show that the combination of the transcription factors Knot and Cut is particular to Drosophila cl...

journal_title：Neuron

authors： Jinushi-Nakao S,Arvind R,Amikura R,Kinameri E,Liu AW,Moore AW

更新日期：2007-12-20 00:00:00

abstract：:Olfactory sensory neurons (OSNs) form synapses with local interneurons and second-order projection neurons to form stereotyped olfactory glomeruli. This primary olfactory circuit is hard-wired through the action of genetic cues. We asked whether individual glomeruli have the capacity for stimulus-evoked plasticity by ...

journal_title：Neuron

authors： Sachse S,Rueckert E,Keller A,Okada R,Tanaka NK,Ito K,Vosshall LB

更新日期：2007-12-06 00:00:00

abstract：:Neurotransmitter release can be synchronous and occur within milliseconds of action potential invasion, or asynchronous and persist for tens of milliseconds. The molecular determinants of release kinetics remain poorly understood. It has been hypothesized that asynchronous release dominates when fast Synaptotagmin iso...

journal_title：Neuron

authors： Turecek J,Regehr WG

更新日期：2019-03-06 00:00:00

abstract：:Presynaptic CaV2 channels are essential for Ca2+-triggered exocytosis. In addition, there are two competing models for their roles in synapse structure. First, Ca2+ channels or Ca2+ entry may control synapse assembly. Second, active zone proteins may scaffold CaV2s to presynaptic release sites, and synapse structure i...

journal_title：Neuron

authors： Held RG,Liu C,Ma K,Ramsey AM,Tarr TB,De Nola G,Wang SSH,Wang J,van den Maagdenberg AMJM,Schneider T,Sun J,Blanpied TA,Kaeser PS

更新日期：2020-08-19 00:00:00

abstract：:Fragile X syndrome is a leading heritable cause of mental retardation that results from the loss of FMR1 gene function. A Drosophila model for Fragile X syndrome, based on the loss of dfmr1 activity, exhibits phenotypes that bear similarity to Fragile X-related symptoms. Herein, we demonstrate that treatment with meta...

journal_title：Neuron

authors： McBride SM,Choi CH,Wang Y,Liebelt D,Braunstein E,Ferreiro D,Sehgal A,Siwicki KK,Dockendorff TC,Nguyen HT,McDonald TV,Jongens TA

更新日期：2005-03-03 00:00:00

abstract：:In uncertain environments, decision-makers must balance two goals: they must "exploit" rewarding options but also "explore" in order to discover rewarding alternatives. Exploring and exploiting necessarily change how the brain responds to identical stimuli, but little is known about how these states, and transitions b...

journal_title：Neuron

authors： Ebitz RB,Albarran E,Moore T

更新日期：2018-01-17 00:00:00

abstract：:Homeostatic regulation of energy balance in rodents changes dramatically during the first 3 postnatal weeks. Neuropeptide Y (NPY) and melanocortin neurons in the arcuate nucleus, a primary energy homeostatic center in adults, do not fully innervate the paraventricular nucleus (PVN) until the third postnatal week. We h...

journal_title：Neuron

authors： Melnick I,Pronchuk N,Cowley MA,Grove KL,Colmers WF

更新日期：2007-12-20 00:00:00

abstract：:The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors and chromatin are thought to regulate gene expression. In the medial ganglionic eminence, the NKX2-1 transcription factor controls regional id...

journal_title：Neuron

authors： Sandberg M,Flandin P,Silberberg S,Su-Feher L,Price JD,Hu JS,Kim C,Visel A,Nord AS,Rubenstein JLR

更新日期：2016-09-21 00:00:00

abstract：:A new study by Yao et al. in the current issue of Cell proposes that a novel vesicular protein, dubbed Flower, regulates endocytosis by controlling presynaptic Ca(2+) levels. This finding is intriguing not only for its implications for vesicle cycling, but also for the multitude of Ca(2+)-dependent processes at play i...

journal_title：Neuron

authors： Kuo SP,Trussell LO

更新日期：2009-09-10 00:00:00

abstract：:Synapses have a limited pool of vesicles that are docked and primed for rapid release. In neuroendocrine cells, splice variants of the SNARE protein SNAP-25 and phosphorylation of SNAP-25 independently influence the size of the releasable vesicle pool, possibly by altering the rate of vesicle depriming. Pre- and postt...

journal_title：Neuron

authors： Heidelberger R,Matthews G

更新日期：2004-02-05 00:00:00

abstract：:Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion i...

journal_title：Neuron

authors： Orr HT

更新日期：2011-10-20 00:00:00

abstract：:It has been postulated that selective temporal coordination between neurons and development of functional neuronal assemblies are fundamental for brain function and behavior. Still, there is little evidence that functionally relevant coordination emerges preferentially in neuronal assemblies directly controlling behav...

journal_title：Neuron

authors： Koralek AC,Costa RM,Carmena JM

更新日期：2013-09-04 00:00:00

abstract：:The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, is a network structure composed of multiple types of neurons. Here, we report that mice with a Bmal1 deletion specific to arginine vasopressin (AVP)-producing neurons showed marked lengthening in the free-running period and activity time of...

journal_title：Neuron

authors： Mieda M,Ono D,Hasegawa E,Okamoto H,Honma K,Honma S,Sakurai T

更新日期：2015-03-04 00:00:00

abstract：:Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus...

journal_title：Neuron

authors： Woods NI,Stefanini F,Apodaca-Montano DL,Tan IMC,Biane JS,Kheirbek MA

更新日期：2020-07-08 00:00:00

abstract：:We developed a technology (capturing activated neuronal ensembles [CANE]) to label, manipulate, and transsynaptically trace neural circuits that are transiently activated in behavioral contexts with high efficiency and temporal precision. CANE consists of a knockin mouse and engineered viruses designed to specifically...

journal_title：Neuron

authors： Sakurai K,Zhao S,Takatoh J,Rodriguez E,Lu J,Leavitt AD,Fu M,Han BX,Wang F

更新日期：2016-11-23 00:00:00

abstract：:The rhodopsin regulatory protein, visual arrestin, undergoes light-dependent trafficking in mammalian and Drosophila photoreceptor cells, though the mechanisms underlying these movements are poorly understood. In Drosophila, the movement of the visual arrestin, Arr2, functions in long-term adaptation and is dependent ...

journal_title：Neuron

authors： Lee SJ,Montell C

更新日期：2004-07-08 00:00:00