Abstract:
:Retrograde signals from postsynaptic targets are critical during development and plasticity of synaptic connections. These signals serve to adjust the activity of presynaptic cells according to postsynaptic cell outputs and to maintain synaptic function within a dynamic range. Despite their importance, the mechanisms that trigger the release of retrograde signals and the role of presynaptic cells in this signaling event are unknown. Here we show that a retrograde signal mediated by Synaptotagmin 4 (Syt4) is transmitted to the postsynaptic cell through anterograde delivery of Syt4 via exosomes. Thus, by transferring an essential component of retrograde signaling through exosomes, presynaptic cells enable retrograde signaling.
journal_name
Neuronjournal_title
Neuronauthors
Korkut C,Li Y,Koles K,Brewer C,Ashley J,Yoshihara M,Budnik Vdoi
10.1016/j.neuron.2013.01.013subject
Has Abstractpub_date
2013-03-20 00:00:00pages
1039-46issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(13)00057-3journal_volume
77pub_type
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