Abstract：
:We generated transgenic mice that specifically express foreign genes in myelinating Schwann cells. A 1.1 kb segment of 5' flanking sequence from the rat P0 gene was used to drive expression of the genes encoding human growth hormone (hGH) and bacterial diphtheria toxin A chain (DT-A). The P0-hGH mice expressed hGH in myelinating Schwann cells, but not in nonmyelinating Schwann cells, the central nervous system, or any other tissue assayed. This expression was activated on a developmental schedule comparable to that of endogenous myelin gene expression. One line of P0-DT-A mice developed a generalized hypomyelinating peripheral neuropathy, with Schwann cell deficiency apparent in newborn animals. Peripheral nerves from adult mice of this line displayed morphological alterations ranging from completely denuded axons to myelinated Schwann cells undergoing degeneration, although occasional Schwann cells were able to form apparently normal myelin sheaths. Pronounced secondary changes, including proliferation and retraction of processes, occurred in the nonmyelinating Schwann cells of these P0-DT-A mice.
journal_name
Neuronjournal_title
Neuronauthors
Messing A,Behringer RR,Hammang JP,Palmiter RD,Brinster RL,Lemke Gdoi
10.1016/0896-6273(92)90279-msubject
Has Abstractpub_date
1992-03-01 00:00:00pages
507-20issue
3eissn
0896-6273issn
1097-4199pii
0896-6273(92)90279-Mjournal_volume
8pub_type
杂志文章相关文献
NEURON文献大全abstract：VIDEO ABSTRACT:The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are poorly understood. Here, we show that the secreted molecule Sonic Hedgehog (Shh) is involved in synapse formation of a specific cortical circuit. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.02.009
更新日期：2012-03-22 00:00:00
abstract：:RNA transport is an important and fundamental event for local protein synthesis, especially in neurons. RNA is transported as large granules, but little is known about them. Here, we isolated a large RNase-sensitive granule (size: 1000S approximately) as a binding partner of conventional kinesin (KIF5). We identified ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.07.022
更新日期：2004-08-19 00:00:00
abstract：:Perceptual inference is biased by foreknowledge about what is probable or possible. How prior expectations are neurally represented during visual perception, however, remains unknown. We used functional magnetic resonance imaging to measure brain activity in humans judging simple visual stimuli. Perceptual decisions w...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.05.021
更新日期：2008-07-31 00:00:00
abstract：:In this issue of Neuron, Kremeyer et al. describe a gain-of-function mutation of TRPA1 that produces a painful disorder, familial episodic pain syndrome. This discovery enlarges the list of ion channels that, when mutated, produce pain. The growing universe of "channelopathic pain" presents some interesting overarchin...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2010.05.029
更新日期：2010-06-10 00:00:00
abstract：:In this issue of Neuron, Gantz and Bean (2017) show that the endocannabinoid 2-arachidonoyl glycerol (2-AG) can directly alter the properties of native ion-channel Kv4.3 and accelerate the pacemaker activity of rodent dopamine neurons. These findings are one of the first demonstrations of postsynaptic, cell-autonomous...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.03.014
更新日期：2017-03-22 00:00:00
abstract：:Striatal dopamine plays key roles in our normal and pathological goal-directed actions. To understand dopamine function, much attention has focused on how midbrain dopamine neurons modulate their firing patterns. However, we identify a presynaptic mechanism that triggers dopamine release directly, bypassing activity i...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.04.038
更新日期：2012-07-12 00:00:00
abstract：:Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, provide insight into the role of NMDA receptors in the cell-specific excito...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/s0896-6273(02)00631-1
更新日期：2002-03-14 00:00:00
abstract：:Small conductance Ca(2+)-activated K(+) (SK) channels and voltage-gated A-type Kv4 channels shape dendritic excitatory postsynaptic potentials (EPSPs) in hippocampal CA1 pyramidal neurons. Synaptically evoked Ca(2+) influx through N-methyl-D-aspartate receptors (NMDARs) activates spine SK channels, reducing EPSPs and ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.11.004
更新日期：2014-01-22 00:00:00
abstract：:Habits are notoriously difficult to break and, if broken, are usually replaced by new routines. To examine the neural basis of these characteristics, we recorded spike activity in cortical and striatal habit sites as rats learned maze tasks. Overtraining induced a shift from purposeful to habitual behavior. This shift...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.05.038
更新日期：2013-07-24 00:00:00
abstract：:Acetylcholinesterase (AChE) density at the neuromuscular junction of frog cutaneous pectoris muscle was determined by electron microscope autoradiography and biochemistry to be approximately 600 sites micron-2 of postsynaptic area, approximately 4-fold lower than all previous reports (mouse), whereas the hydrolytic tu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90331-x
更新日期：1994-04-01 00:00:00
abstract：:Pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. Although tau aggregation is associated with abnormal tau phosphorylation, the role of phosphorylation in the initiation of neurodegeneration has been unclear. Now, several animal models and data f...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(03)00681-0
更新日期：2003-10-30 00:00:00
abstract：:According to economic theories, preference for one item over others reveals its rank value on a common scale. Previous studies identified brain regions encoding such values. Here we verify that these regions can valuate various categories of objects and further test whether they still express preferences when attentio...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.09.040
更新日期：2009-11-12 00:00:00
abstract：:Gene transcription is the process by which the genetic codes of organisms are read and interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As cells function in their respective niches, transcription further allows mature cells to interact dynamically with their external enviro...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2018.10.013
更新日期：2018-10-24 00:00:00
abstract：:Based on extrapolation from excitatory synapses, it is often assumed that depletion of the releasable pool of synaptic vesicles is the main factor underlying depression at inhibitory synapses. In this issue of Neuron, using subcellular patch-clamp recording from inhibitory presynaptic terminals, Kawaguchi and Sakaba (...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2015.03.006
更新日期：2015-03-18 00:00:00
abstract：:Brain functions are based on the dynamic interaction of excitatory and inhibitory inputs. Spillover of glutamate from excitatory synapses may diffuse to and modulate nearby inhibitory synapses. By recording unitary inhibitory postsynaptic currents (uIPSCs) from cell pairs in CA1 of the hippocampus, we demonstrated tha...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00298-7
更新日期：2001-05-01 00:00:00
abstract：:Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron su...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.03.025
更新日期：2011-06-09 00:00:00
abstract：:Neuroligins (NLs) are critical for synapse formation and function. NL3 R451C is an autism-associated mutation. NL3 R451C knockin (KI) mice exhibit autistic behavioral abnormalities, including social novelty deficits. However, neither the brain regions involved in social novelty nor the underlying mechanisms are clearl...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.02.001
更新日期：2018-03-21 00:00:00
abstract：:Motoneuron-derived agrin clusters nicotinic acetylcholine receptors (AChRs) in mammalian muscle cells. We used two-hybrid screens to identify a protein, tumorous imaginal discs (Tid1), that binds to the cytoplasmic domain of muscle-specific kinase (MuSK), a major component of the agrin receptor. Like MuSK, Tid1 coloca...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.09.025
更新日期：2008-11-26 00:00:00
abstract：:Little is known about genetic mechanisms that regulate the ratio of cortical excitatory and inhibitory neurons. We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE). NPAS1(-/-) mutants had increased proliferation, ERK signali...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.10.040
更新日期：2014-12-03 00:00:00
abstract：:Oscillatory activity in the basolateral amygdala (BLA) is critical for emotional behavior. In this issue of Neuron, Stujenske et al. (2014) describe novel dynamics of BLA theta-gamma-coupled neuronal oscillations associated with conditioned and innate fear. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2014.08.014
更新日期：2014-08-20 00:00:00
abstract：:Using exome sequencing, we identified a p.R191Q amino acid change in the valosin-containing protein (VCP) gene in an Italian family with autosomal dominantly inherited amyotrophic lateral sclerosis (ALS). Mutations in VCP have previously been identified in families with Inclusion Body Myopathy, Paget disease, and Fron...
journal_title：Neuron
pub_type： 杂志文章,多中心研究
doi：10.1016/j.neuron.2010.11.036
更新日期：2010-12-09 00:00:00
abstract：:For efficient coding, sensory systems need to adapt to the distribution of signals to which they are exposed. In vision, natural scenes above and below the horizon differ in the distribution of chromatic and achromatic features. Consequently, many species differentially sample light in the sky and on the ground using ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.09.030
更新日期：2013-12-04 00:00:00
abstract：:A recent paper in Nature (Lim et al., 2012) describes the effects of melanocortin receptors in the nucleus accumbens. The studies connect a hypothalamic peptide system with brain reward centers and show effects on specific neuronal populations and behavioral components of mood. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2012.07.018
更新日期：2012-08-09 00:00:00
abstract：:To evaluate the role in synaptic plasticity of ryanodine receptor type 3 (RyR3), which is normally enriched in hippocampal area CA1, we generated RyR3-deficient mice. Mutant mice exhibited facilitated CA1 long-term potentiation (LTP) induced by short tetanus (100 Hz, 100 ms) stimulation. Unlike LTP in wild-type mice, ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81123-x
更新日期：1999-11-01 00:00:00
abstract：:Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.12.006
更新日期：2010-01-14 00:00:00
abstract：:Acquisition of new learning is challenged by the phenomenon of proactive interference (PI), which occurs when previous learning disrupts later learning. Whereas human neuroimaging studies have focused on the cortical contributions to interference resolution, animal studies demonstrate that efficient resolution of PI d...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(04)00080-7
更新日期：2004-03-04 00:00:00
abstract：:We have determined the sequences of isoforms of human tau protein, which differ from previously reported forms by insertions of 29 or 58 amino acids in the amino-terminal region. Complementary DNA cloning shows that the insertions occur in combination with both three and four tandem repeats. RNAase protection assays i...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(89)90210-9
更新日期：1989-10-01 00:00:00
abstract：:Synapses are lost during developmental synapse elimination. Until now, it has been impossible to follow elimination in the entirety of any neuron's branches and synapses. Using transgenic mice in which one or two of a muscle's motoneurons express variants of GFP, Keller-Peck et al. show in this issue of Neuron that el...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/s0896-6273(01)00380-4
更新日期：2001-08-16 00:00:00
abstract：:Functional neuroimaging uses activity-dependent changes in cerebral blood flow to map brain activity, but the contributions of presynaptic and postsynaptic activity are incompletely understood, as are the underlying cellular pathways. Using intravital multiphoton microscopy, we measured presynaptic activity, postsynap...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.04.029
更新日期：2008-06-26 00:00:00
abstract：:Human confidence judgments are thought to originate from metacognitive processes that provide a subjective assessment about one's beliefs. Alternatively, confidence is framed in mathematics as an objective statistical quantity: the probability that a chosen hypothesis is correct. Despite similar terminology, it remain...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.03.025
更新日期：2016-05-04 00:00:00
