Abstract：
:For each environment a rodent has explored, its hippocampus contains a map consisting of a unique subset of neurons, called place cells, that have spatially tuned spiking there, with the remaining neurons being essentially silent. Using whole-cell recording in freely moving rats exploring a novel maze, we observed differences in intrinsic cellular properties and input-based subthreshold membrane potential levels underlying this division into place and silent cells. Compared to silent cells, place cells had lower spike thresholds and peaked versus flat subthreshold membrane potentials as a function of animal location. Both differences were evident from the beginning of exploration. Additionally, future place cells exhibited higher burst propensity before exploration. Thus, internal settings appear to predetermine which cells will represent the next novel environment encountered. Furthermore, place cells fired spatially tuned bursts with large, putatively calcium-mediated depolarizations that could trigger plasticity and stabilize the new map for long-term storage. Our results provide new insight into hippocampal memory formation.
journal_name
Neuronjournal_title
Neuronauthors
Epsztein J,Brecht M,Lee AKdoi
10.1016/j.neuron.2011.03.006subject
Has Abstractpub_date
2011-04-14 00:00:00pages
109-20issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(11)00196-6journal_volume
70pub_type
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