Abstract:
:Targeted therapy for neuropsychiatric disorders requires selective modulation of dysfunctional neuronal pathways. Receptors relevant to CNS disorders typically have associated proteins discretely expressed in specific neuronal pathways; these accessory proteins provide a new dimension for drug discovery. Recent studies show that targeting a TARP auxiliary subunit of AMPA receptors selectively modulates neuronal excitability in specific forebrain pathways relevant to epilepsy. Other medicinally important ion channels, gated by glutamate, γ-aminobutyric acid (GABA), and acetylcholine, also have associated proteins, which may be druggable. This emerging pharmacology of receptor-associated proteins provides a new approach for improving drug efficacy while mitigating side effects.
journal_name
Neuronjournal_title
Neuronauthors
Maher MP,Matta JA,Gu S,Seierstad M,Bredt DSdoi
10.1016/j.neuron.2017.10.001subject
Has Abstractpub_date
2017-12-06 00:00:00pages
989-1001issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30930-3journal_volume
96pub_type
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