Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins.

Abstract:

:Targeted therapy for neuropsychiatric disorders requires selective modulation of dysfunctional neuronal pathways. Receptors relevant to CNS disorders typically have associated proteins discretely expressed in specific neuronal pathways; these accessory proteins provide a new dimension for drug discovery. Recent studies show that targeting a TARP auxiliary subunit of AMPA receptors selectively modulates neuronal excitability in specific forebrain pathways relevant to epilepsy. Other medicinally important ion channels, gated by glutamate, γ-aminobutyric acid (GABA), and acetylcholine, also have associated proteins, which may be druggable. This emerging pharmacology of receptor-associated proteins provides a new approach for improving drug efficacy while mitigating side effects.

journal_name

Neuron

journal_title

Neuron

authors

Maher MP,Matta JA,Gu S,Seierstad M,Bredt DS

doi

10.1016/j.neuron.2017.10.001

subject

Has Abstract

pub_date

2017-12-06 00:00:00

pages

989-1001

issue

5

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(17)30930-3

journal_volume

96

pub_type

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