Abstract：
:Auditory receptor cells rely on mechanically gated channels to transform sound stimuli into neural activity. Several TRP channels have been implicated in Drosophila auditory transduction, but mechanistic studies have been hampered by the inability to record subthreshold signals from receptor neurons. Here, we develop a non-invasive method for measuring these signals by recording from a central neuron that is electrically coupled to a genetically defined population of auditory receptor cells. We find that the TRPN family member NompC, which is necessary for the active amplification of sound-evoked motion by the auditory organ, is not required for transduction in auditory receptor cells. Instead, NompC sensitizes the transduction complex to movement and precisely regulates the static forces on the complex. In contrast, the TRPV channels Nanchung and Inactive are required for responses to sound, suggesting they are components of the transduction complex. Thus, transduction and active amplification are genetically separable processes in Drosophila hearing.
journal_name
Neuronjournal_title
Neuronauthors
Lehnert BP,Baker AE,Gaudry Q,Chiang AS,Wilson RIdoi
10.1016/j.neuron.2012.11.030subject
Has Abstractpub_date
2013-01-09 00:00:00pages
115-28issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(12)01115-4journal_volume
77pub_type
杂志文章相关文献
NEURON文献大全abstract：:Real-time activity measurements of genetically identified neuroendocrine vasopressin neurons show they can anticipate osmotic challenges. In this issue of Neuron, Mandelblat-Cerf et al. (2017) show that correlating these results with ongoing behavior and plasma osmolality points to the existence of brain networks that...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.12.033
更新日期：2017-01-04 00:00:00
abstract：:Spine Ca(2+) is critical for the induction of synaptic plasticity, but the factors that control Ca(2+) handling in dendritic spines under physiological conditions are largely unknown. We studied [Ca(2+)] signaling in dendritic spines of CA1 pyramidal neurons and find that spines are specialized structures with low end...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00573-1
更新日期：2002-01-31 00:00:00
abstract：:Gene expression may occur in unexpected ectopic sites when diverse genetic elements are juxtaposed as chimeric genes in transgenic mice. To determine the specific contribution of the promoter and reporter gene in ectopic expression, we have analyzed the expression of 14 different fusion genes in transgenic mice. Chime...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(88)90079-7
更新日期：1988-06-01 00:00:00
abstract：:Endocannabinoids are released after brain injury and believed to attenuate neuronal damage by binding to CB(1) receptors and protecting against excitotoxicity. Such excitotoxic brain lesions initially result in primary destruction of brain parenchyma, which attracts macrophages and microglia. These inflammatory cells ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.11.027
更新日期：2006-01-05 00:00:00
abstract：:K(ATP) channels are large heteromultimeric complexes containing four subunits from the inwardly rectifying K+ channel family (Kir6.2) and four regulatory sulphonylurea receptor subunits from the ATP-binding cassette (ABC) transporter family (SUR1 and SUR2A/B). The molecular basis for interactions between these two unr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81146-0
更新日期：2000-04-01 00:00:00
abstract：:The bendless (ben) mutation of Drosophila alters synaptic connectivity between a subset of CNS neurons. Here, we show that ben also causes morphological abnormalities within the visual system, suggesting that ben functions in a number of different developmental processes. We show that the ben gene encodes a protein wh...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90182-q
更新日期：1993-08-01 00:00:00
abstract：:Neuroanatomical and functional asymmetries are universal features of the vertebrate CNS, but how asymmetry is generated is unknown. Here we show that zebrafish fgf8 mutants do not elaborate forebrain asymmetries, demonstrated by the failure of the parapineal nucleus to migrate from its initial midline position to the ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.11.030
更新日期：2009-01-15 00:00:00
abstract：:The posterior septum consisting of the triangular septum (TS) and the bed nucleus of the anterior commissure (BAC) is predominantly linked with the medial habenula (MHb) and has been implicated in the control of anxiety and fear responses. However, its anatomical and functional linkage has largely remained elusive. We...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.02.035
更新日期：2013-05-08 00:00:00
abstract：:Synaptic activity induces changes in the number of dendritic spines. Here, we report a pathway of regulated endocytosis triggered by arcadlin, a protocadherin induced by electroconvulsive and other excitatory stimuli in hippocampal neurons. The homophilic binding of extracellular arcadlin domains activates TAO2beta, a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.08.020
更新日期：2007-11-08 00:00:00
abstract：:We show here that antisense MAP2 oligonucleotides inhibit neurite outgrowth in cultured cerebellar macroneurons. Unlike control neurons, which first extend a lamellipodial veil followed by a consolidation phase during which the cells extend minor neurites, MAP2-suppressed cells persist with lamellipodia and later beco...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90025-9
更新日期：1992-10-01 00:00:00
abstract：:Trk tyrosine kinases are receptors for members of the neurotrophin family and are crucial for growth and survival of specific populations of neurons. Yet, the functions of neurotrophin-Trk signaling in postnatal development as well as maintenance and plasticity of the adult nervous system are less clear. We report her...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.03.009
更新日期：2005-04-07 00:00:00
abstract：:We measured brain activity during mental rotation and object recognition with objects rotated around three different axes. Activity in the superior parietal lobe (SPL) increased proportionally to viewpoint disparity during mental rotation, but not during object recognition. In contrast, the fusiform gyrus was preferen...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00622-0
更新日期：2002-03-28 00:00:00
abstract：:At the optic chiasm, axons from either eye meet and decide whether to cross contralaterally or turn back ipsilaterally. Here, the guidance ligand Slit and its receptor Robo control not whether axons cross (as in other midline decisions), but where the chiasm forms. Whether axons cross is instead controlled by the tran...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(03)00563-4
更新日期：2003-09-11 00:00:00
abstract：:The production of new neurons in the adult hippocampus is exquisitely regulated, and alterations in this process may underlie both normal and pathological hippocampal function. In this issue of Neuron, Tozuka et al. describe electrophysiological recordings that target proliferating progenitor cells in adult mouse hipp...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2005.08.029
更新日期：2005-09-15 00:00:00
abstract：:Much recent discussion about the origin of Parkinsonian symptoms has centered around the idea that they arise with the increase of beta frequency waves in the EEG. This activity may be closely related to an oscillation between subthalamic nucleus (STN) and globus pallidus. Since STN is the target of deep brain stimula...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.09.032
更新日期：2012-12-06 00:00:00
abstract：:Olfactory receptor neurons (ORNs) do not express the typical neuronal intermediate filament proteins (IFPs), the neurofilament triplet proteins. Immunocytochemical evidence shows that ORNs coexpress vimentin and peripherin but distribute them differently. Specifically, ORNs contain vimentin in dendrites, cell bodies, ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(91)90300-o
更新日期：1991-09-01 00:00:00
abstract：:Fibroblastic 3T3 and endocrine RIN cells were genetically modified by infection with a recombinant retrovirus encoding the form I of human tyrosine hydroxylase (TH) and selection in tyrosine-free medium. These cells were grafted to rats unilaterally lesioned with 6-hydroxy-dopamine. Both cell types survived implantati...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90078-t
更新日期：1990-10-01 00:00:00
abstract：:Small conductance Ca(2+)-activated K(+) (SK) channels and voltage-gated A-type Kv4 channels shape dendritic excitatory postsynaptic potentials (EPSPs) in hippocampal CA1 pyramidal neurons. Synaptically evoked Ca(2+) influx through N-methyl-D-aspartate receptors (NMDARs) activates spine SK channels, reducing EPSPs and ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.11.004
更新日期：2014-01-22 00:00:00
abstract：:The processing of sensory information varies widely across behavioral states. However, little is known about how behavioral states modulate the intracellular activity of cortical neurons to effect changes in sensory responses. Here, we performed whole-cell recordings from neurons in upper-layer primary visual cortex o...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.08.007
更新日期：2013-10-16 00:00:00
abstract：:Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the ANS regulates stem ce...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2015.01.026
更新日期：2015-04-22 00:00:00
abstract：:The neurotrophin survival dependence of peripheral neurons in vitro is regulated by the proapoptotic BCL-2 homolog BAX. To study peripheral neuron development in the absence of neurotrophin signaling, we have generated mice that are double null for BAX and nerve growth factor (NGF), and BAX and the NGF receptor TrkA. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80899-5
更新日期：2000-02-01 00:00:00
abstract：:We describe recent progress toward defining neuronal cell types in the mouse retina and attempt to extract lessons that may be generally useful in the mammalian brain. Achieving a comprehensive catalog of retinal cell types now appears within reach, because researchers have achieved consensus concerning two fundamenta...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2014.08.054
更新日期：2014-09-17 00:00:00
abstract：:Presynaptic CaV2 channels are essential for Ca2+-triggered exocytosis. In addition, there are two competing models for their roles in synapse structure. First, Ca2+ channels or Ca2+ entry may control synapse assembly. Second, active zone proteins may scaffold CaV2s to presynaptic release sites, and synapse structure i...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.05.032
更新日期：2020-08-19 00:00:00
abstract：:Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's disease (AD) bring cholesterol to the forefront of AD research. Research from genetics, epidemiology, and cell biology all converge, suggesting that cholesterol plays a central role in the biology of amyloid precursor protein and t...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(03)00840-7
更新日期：2004-01-08 00:00:00
abstract：:The role of early visual experience in the establishment of human high-order visual areas is poorly understood. Here we investigated this issue using human amblyopia--a developmental visual disorder, which manifests a central vision (acuity) deficit. Previous fMRI studies of amblyopes have described abnormal functiona...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00720-7
更新日期：2003-12-04 00:00:00
abstract：:Examining the behavioral consequences of selective CNS neuronal activation is a powerful tool for elucidating mammalian brain function in health and disease. Newly developed genetic, pharmacological, and optical tools allow activation of neurons with exquisite spatiotemporal resolution; however, the inaccessibility to...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.06.014
更新日期：2009-07-16 00:00:00
abstract：:Degeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive dysfunction in Alzheimer's disease (AD) and Down's syndrome (DS). We used Ts65Dn and Ts1Cje mouse models of DS to show that the increased dose of the amyloid precursor protein gene, App, acts to markedly decrease NGF retrograde transp...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.05.022
更新日期：2006-07-06 00:00:00
abstract：:Mouse vision is based on the parallel output of more than 30 functional types of retinal ganglion cells (RGCs). Little is known about how representations of visual information change between retina and dorsolateral geniculate nucleus (dLGN) of the thalamus, the main relay between retina and cortex. Here, we functional...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.01.040
更新日期：2019-04-17 00:00:00
abstract：:Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative disorder Huntington's disease (HD). The gene encoding huntingtin, HTT, and its dominantly inherited mutation were identified more than 20 years ago...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2016.02.003
更新日期：2016-03-02 00:00:00
abstract：:Pheromonal activation of the vomeronasal organ (VNO) elicits genetically preprogrammed behaviors and physiological changes in mammals. We have identified a novel gene family encoding over one hundred VNO specific receptors, the V3Rs. V3R sequences are highly similar to each other and appear distantly related to the pu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)00157-4
更新日期：2000-12-01 00:00:00
