Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.

abstract：:Opioid neuropeptides and their receptors are evolutionarily conserved neuromodulatory systems that profoundly influence behavior. In dorsal striatum, which expresses the endogenous opioid enkephalin, patches (or striosomes) are limbic-associated subcompartments enriched in mu opioid receptors. The functional implicati...

journal_title：Neuron

authors： Banghart MR,Neufeld SQ,Wong NC,Sabatini BL

更新日期：2015-12-16 00:00:00

abstract：:To assess the role of exocytotic release in signaling by monoamines, we have disrupted the neuronal vesicular monoamine transporter 2 (VMAT2) gene. VMAT2-/- mice move little, feed poorly, and die within a few days after birth. Monoamine cell groups and their projections are indistinguishable from those of wild-type li...

journal_title：Neuron

authors： Fon EA,Pothos EN,Sun BC,Killeen N,Sulzer D,Edwards RH

更新日期：1997-12-01 00:00:00

abstract：:Molecular determinants of Ca2+ channel responsiveness to inhibition by receptor-coupled G proteins were investigated in Xenopus oocytes. The inhibitory response of alpha1B (N-type) channels was much larger than alpha1A (P/Q-type) channels, while alpha1C (L-type) channels were unresponsive. Differences in both degree a...

journal_title：Neuron

authors： Zhang JF,Ellinor PT,Aldrich RW,Tsien RW

更新日期：1996-11-01 00:00:00

abstract：:Lattice-like structures known as perineuronal nets (PNNs) are key components of the extracellular matrix (ECM). Once fully crystallized by adulthood, they are largely stable throughout life. Contrary to previous reports that PNNs inhibit processes involving plasticity, here we report that the dynamic regulation of PNN...

journal_title：Neuron

authors： Banerjee SB,Gutzeit VA,Baman J,Aoued HS,Doshi NK,Liu RC,Ressler KJ

更新日期：2017-07-05 00:00:00

abstract：:The long-term depression (LTD) of parallel fiber (PF) synapses onto Purkinje cells plays a central role in motor learning. Endocannabinoid release and LTD induction both depend upon activation of the metabotropic glutamate receptor mGluR1, require postsynaptic calcium increases, are synapse specific, and have a simila...

journal_title：Neuron

authors： Safo PK,Regehr WG

更新日期：2005-11-23 00:00:00

abstract：:Neural synchronization plays an important role in information flow in the nervous system under healthy and pathological conditions. In this issue of Neuron, Gittis et al. show that reorganization of striatal microcircuits promotes synchronous activity and may underlie the pathological network oscillations at the root ...

journal_title：Neuron

authors： Belujon P,Grace AA

更新日期：2011-09-08 00:00:00

abstract：:In the brain, enormous numbers of neurons have functional individuality and distinct circuit specificities. Clustered Protocadherins (Pcdhs), diversified cell-surface proteins, are stochastically expressed by alternative promoter choice and affect dendritic arborization in individual neurons. Here we found that the Pc...

journal_title：Neuron

authors： Toyoda S,Kawaguchi M,Kobayashi T,Tarusawa E,Toyama T,Okano M,Oda M,Nakauchi H,Yoshimura Y,Sanbo M,Hirabayashi M,Hirayama T,Hirabayashi T,Yagi T

更新日期：2014-04-02 00:00:00

abstract：:Quantitative differences in cadherin activity have been proposed to play important roles in patterning connections between pre- and postsynaptic neurons. However, no examples of such a function have yet been described, and the mechanisms that would allow such differences to direct growth cones to specific synaptic tar...

journal_title：Neuron

authors： Chen PL,Clandinin TR

更新日期：2008-04-10 00:00:00

abstract：:Attention or variations in event processing help drive learning. Lesion studies have implicated the central nucleus of the amygdala (CeA) in this process, particularly when expected rewards are omitted. However, lesion studies cannot specify how information processing in CeA supports such learning. To address these qu...

journal_title：Neuron

authors： Calu DJ,Roesch MR,Haney RZ,Holland PC,Schoenbaum G

更新日期：2010-12-09 00:00:00

abstract：:A study by Zhang et al. in this issue of Neuron reveals a novel mechanism of control of vestibular motor functions by the orexin (hypocretin) system in the perifornical/LH area through the lateral vestibular nucleus in the brainstem. This knowledge provides new insights into the understanding of brain circuitry that c...

journal_title：Neuron

authors： Gao XB,Horvath TL

更新日期：2011-02-24 00:00:00

abstract：:Adolescence is often described as a period of heightened reactivity to emotions paired with reduced regulatory capacities, a combination suggested to contribute to risk-taking and susceptibility to peer influence during puberty. However, no longitudinal research has definitively linked these behavioral changes to unde...

journal_title：Neuron

authors： Pfeifer JH,Masten CL,Moore WE 3rd,Oswald TM,Mazziotta JC,Iacoboni M,Dapretto M

更新日期：2011-03-10 00:00:00

abstract：:Olfactory receptor neurons (ORNs) are replaced and differentiate in adult animals, but differentiation in dissociated cell culture has not been demonstrated. To test whether contact with the CNS regulates maturation, neonatal rat olfactory cells were grown on a culture substrate or on CNS astrocytes. Mature ORNs, immu...

journal_title：Neuron

authors： Pixley SK

更新日期：1992-06-01 00:00:00

abstract：:Yoon et al. (2017) uncover a key role for the m6A RNA mark in regulating the timing of cerebral cortex development in mouse and human. This discovery opens new avenues of exploration into how the epitranscriptome helps orchestrate central nervous system formation. ...

journal_title：Neuron

authors： Boles NC,Temple S

更新日期：2017-11-15 00:00:00

abstract：:Ephrin signaling through Eph receptor tyrosine kinases can promote attraction or repulsion of axonal growth cones during development. However, the mechanisms that determine whether Eph signaling promotes attraction or repulsion are not known. We show here that the Rho family GEF Vav2 plays a key role in this process. ...

journal_title：Neuron

authors： Cowan CW,Shao YR,Sahin M,Shamah SM,Lin MZ,Greer PL,Gao S,Griffith EC,Brugge JS,Greenberg ME

更新日期：2005-04-21 00:00:00

abstract：:Brief depolarization of cerebellar Purkinje cells was found to inhibit parallel fiber and climbing fiber EPSCs for tens of seconds. This depolarization-induced suppression of excitation (DSE) is accompanied by altered paired-pulse plasticity, suggesting a presynaptic locus. Fluorometric imaging revealed that postsynap...

journal_title：Neuron

authors： Kreitzer AC,Regehr WG

更新日期：2001-03-01 00:00:00

abstract：:Light plays a pivotal role in the regulation of affective behaviors. However, the precise circuits that mediate the impact of light on depressive-like behaviors are not well understood. Here, we show that light influences depressive-like behaviors through a disynaptic circuit linking the retina and the lateral habenul...

journal_title：Neuron

authors： Huang L,Xi Y,Peng Y,Yang Y,Huang X,Fu Y,Tao Q,Xiao J,Yuan T,An K,Zhao H,Pu M,Xu F,Xue T,Luo M,So KF,Ren C

更新日期：2019-04-03 00:00:00

abstract：:Circadian clocks consist of transcriptional feedback loops housed in interdependent pacemaker neurons. Yet little is known about the neuronal output components essential for rhythmic behavior. Drosophila mutants of a putative ion channel, narrow abdomen (na), exhibit poor circadian rhythms and suppressed daylight acti...

journal_title：Neuron

authors： Lear BC,Lin JM,Keath JR,McGill JJ,Raman IM,Allada R

更新日期：2005-12-22 00:00:00

abstract：:For each environment a rodent has explored, its hippocampus contains a map consisting of a unique subset of neurons, called place cells, that have spatially tuned spiking there, with the remaining neurons being essentially silent. Using whole-cell recording in freely moving rats exploring a novel maze, we observed dif...

journal_title：Neuron

authors： Epsztein J,Brecht M,Lee AK

更新日期：2011-04-14 00:00:00

abstract：:In the visual cortex of many mammals, orientation preference changes smoothly along the cortical surface, with the exception of singularities such as pinwheels and fractures. The reason for the existence of these singularities has remained elusive, suggesting that they are developmental artifacts. We show that singula...

journal_title：Neuron

authors： Koulakov AA,Chklovskii DB

更新日期：2001-02-01 00:00:00

abstract：:Studies of the innervation of limb muscles by spinal motor neurons have helped to define mechanisms by which axons establish trajectories to their targets. Related motor axons select dorsal or ventral pathways at the base of the limb, raising the question of how these alternate trajectories are specified. EphA signali...

journal_title：Neuron

authors： Luria V,Krawchuk D,Jessell TM,Laufer E,Kania A

更新日期：2008-12-26 00:00:00

abstract：:The controversy about whether dopamine contributes to cell loss in Parkinson's disease takes a new turn as Mosharov et al. in this issue of Neuron demonstrate that Ca2+ influx through L-type channels elevates dopamine synthesis to potentially toxic levels in vulnerable ventral mesencephalon neurons. ...

journal_title：Neuron

authors： Surmeier DJ

更新日期：2009-04-30 00:00:00

abstract：:A proposal for an Australian Brain Initiative (ABI) is under development by members of the Australian Brain Alliance. Here we discuss the goals of the ABI, its areas of research focus, its context in the Australian research setting, and its necessity for ensuring continued success for Australian brain research. ...

journal_title：Neuron

authors： Australian Brain Alliance Steering Committee.

更新日期：2016-11-02 00:00:00

abstract：:Within the medial frontal cortex, the supplementary eye field (SEF), supplementary motor area (SMA), and pre-SMA have been implicated in the control of voluntary action, especially during motor sequences or tasks involving rapid choices between competing response plans. However, the precise roles of these areas remain...

journal_title：Neuron

authors： Sumner P,Nachev P,Morris P,Peters AM,Jackson SR,Kennard C,Husain M

更新日期：2007-06-07 00:00:00

abstract：:The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo during endocytosis is critical for the maintenance of neurotransmission. During intense neuronal activity, a transient and acute accumulation of SV cargo occurs at the plasma membrane. Activity-dependent bulk endocytosis (ADBE) ...

journal_title：Neuron

authors： Nicholson-Fish JC,Kokotos AC,Gillingwater TH,Smillie KJ,Cousin MA

更新日期：2015-12-02 00:00:00

abstract：:Rho GTPases are essential regulators of cytoskeletal reorganization, but how they do so during neuronal morphogenesis in vivo is poorly understood. Here we show that the actin depolymerization factor cofilin is essential for axon growth in Drosophila neurons. Cofilin function in axon growth is inhibited by LIM kinase ...

journal_title：Neuron

authors： Ng J,Luo L

更新日期：2004-12-02 00:00:00

abstract：:People are embedded in social interaction that shapes their brains throughout lifetime. Instead of emerging from lower-level cognitive functions, social interaction could be the default mode via which humans communicate with their environment. Should this hypothesis be true, it would have profound implications on how ...

journal_title：Neuron

authors： Hari R,Henriksson L,Malinen S,Parkkonen L

更新日期：2015-10-07 00:00:00

abstract：:Action potentials initiate in the axon initial segment (AIS), a specialized compartment enriched with Na(+) and K(+) channels. Recently, we found that T- and R-type Ca(2+) channels are concentrated in the AIS, where they contribute to local subthreshold membrane depolarization and thereby influence action potential in...

journal_title：Neuron

authors： Bender KJ,Ford CP,Trussell LO

更新日期：2010-11-04 00:00:00

abstract：:Inhibition of granule cells plays a key role in gating the flow of signals into the cerebellum, and it is thought that Golgi cells are the only interneurons that inhibit granule cells. Here we show that Purkinje cells, the sole output neurons of the cerebellar cortex, also directly inhibit granule cells via their axon...

journal_title：Neuron

authors： Guo C,Witter L,Rudolph S,Elliott HL,Ennis KA,Regehr WG

更新日期：2016-09-21 00:00:00

abstract：:Neuromodulators regulate circuits throughout the nervous system, and revealing the cell types and stimulus conditions controlling their release is vital to understanding their function. The effects of the neuromodulator nitric oxide (NO) have been studied in many circuits, including in the vertebrate retina, where it ...

journal_title：Neuron

authors： Jacoby J,Nath A,Jessen ZF,Schwartz GW

更新日期：2018-12-05 00:00:00

abstract：:Visual information reaches the brain by way of a fine cable, the optic nerve. The million or so axons in the optic nerve represent an information bottleneck in the visual pathway-where the fewest number of neurons convey the visual scene. It has long been thought that to make the most of the optic nerve's limited capa...

journal_title：Neuron

authors： Mukamel EA,Schnitzer MJ

更新日期：2005-05-05 00:00:00