Abstract:
:The fidelity with which spinal motor neurons innervate their limb target muscles helps to coordinate motor behavior, but the mechanisms that determine precise patterns of nerve-muscle connectivity remain obscure. We show that Nkx6 proteins, a set of Hox-regulated homeodomain transcription factors, are expressed by motor pools soon after motor neurons leave the cell cycle, before the formation of muscle nerve side branches in the limb. Using mouse genetics, we show that the status of Nkx6.1 expression in certain motor neuron pools regulates muscle nerve formation, and the pattern of innervation of individual muscles. Our findings provide genetic evidence that neurons within motor pools possess an early transcriptional identity that controls target muscle specificity.
journal_name
Neuronjournal_title
Neuronauthors
De Marco Garcia NV,Jessell TMdoi
10.1016/j.neuron.2007.11.033subject
Has Abstractpub_date
2008-01-24 00:00:00pages
217-31issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(07)01023-9journal_volume
57pub_type
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