Innovations in the imaging of brain functions using fluorescent proteins.

abstract：:Oxytocin (OT) release by axonal terminals onto the central nucleus of the amygdala exerts anxiolysis. To investigate which subpopulation of OT neurons contributes to this effect, we developed a novel method: virus-delivered genetic activity-induced tagging of cell ensembles (vGATE). With the vGATE method, we identifie...

journal_title：Neuron

authors： Hasan MT,Althammer F,Silva da Gouveia M,Goyon S,Eliava M,Lefevre A,Kerspern D,Schimmer J,Raftogianni A,Wahis J,Knobloch-Bollmann HS,Tang Y,Liu X,Jain A,Chavant V,Goumon Y,Weislogel JM,Hurlemann R,Herpertz SC,Pitzer

更新日期：2019-07-03 00:00:00

abstract：:Motoneuron-derived agrin clusters nicotinic acetylcholine receptors (AChRs) in mammalian muscle cells. We used two-hybrid screens to identify a protein, tumorous imaginal discs (Tid1), that binds to the cytoplasmic domain of muscle-specific kinase (MuSK), a major component of the agrin receptor. Like MuSK, Tid1 coloca...

journal_title：Neuron

authors： Linnoila J,Wang Y,Yao Y,Wang ZZ

更新日期：2008-11-26 00:00:00

abstract：:Oscillatory activity in the basolateral amygdala (BLA) is critical for emotional behavior. In this issue of Neuron, Stujenske et al. (2014) describe novel dynamics of BLA theta-gamma-coupled neuronal oscillations associated with conditioned and innate fear. ...

journal_title：Neuron

authors： Bocchio M,Capogna M

更新日期：2014-08-20 00:00:00

abstract：:Interaction with the multi-PDZ protein GRIP is required for the synaptic targeting of AMPA receptors, but the underlying mechanism is unknown. We show that GRIP binds to the liprin-alpha/SYD2 family of proteins that interact with LAR receptor protein tyrosine phosphatases (LAR-RPTPs) and that are implicated in presyna...

journal_title：Neuron

authors： Wyszynski M,Kim E,Dunah AW,Passafaro M,Valtschanoff JG,Serra-Pagès C,Streuli M,Weinberg RJ,Sheng M

更新日期：2002-03-28 00:00:00

abstract：:Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupled with promoter mi...

journal_title：Neuron

authors： Renthal W,Kumar A,Xiao G,Wilkinson M,Covington HE 3rd,Maze I,Sikder D,Robison AJ,LaPlant Q,Dietz DM,Russo SJ,Vialou V,Chakravarty S,Kodadek TJ,Stack A,Kabbaj M,Nestler EJ

更新日期：2009-05-14 00:00:00

abstract：:Neural representations of head direction (HD) have been discovered in many species. Theoretical work has proposed that the dynamics associated with these representations are generated, maintained, and updated by recurrent network structures called ring attractors. We evaluated this theorized structure-function relatio...

journal_title：Neuron

authors： Turner-Evans DB,Jensen KT,Ali S,Paterson T,Sheridan A,Ray RP,Wolff T,Lauritzen JS,Rubin GM,Bock DD,Jayaraman V

更新日期：2020-10-14 00:00:00

abstract：:Recent genetic evidence indicates that neuregulin 1 (NRG1) and its receptor erbB4 may be susceptibility genes in schizophrenia, but their function in CNS synaptic transmission and circuitry is not well understood. In this issue of Neuron, studies from Li et al. and Woo et al. show that NRG1 and erbB4 regulate transmis...

journal_title：Neuron

authors： Fischbach GD

更新日期：2007-05-24 00:00:00

abstract：:The frontline anti-malarial drug artemisinin and its derivatives have also been implicated in modulating multiple mammalian cellular pathways, including the recent identification of targeting γ-aminobutyric acid type A receptor (GABAAR) signaling in the pancreas. Their molecular mechanism of action, however, remains e...

journal_title：Neuron

authors： Kasaragod VB,Hausrat TJ,Schaefer N,Kuhn M,Christensen NR,Tessmer I,Maric HM,Madsen KL,Sotriffer C,Villmann C,Kneussel M,Schindelin H

更新日期：2019-02-20 00:00:00

abstract：:The visual cortex represents stimuli through the activity of neuronal populations. We measured the evolution of this activity in space and time by imaging voltage-sensitive dyes in cat area V1. Contrast-reversing stimuli elicit responses that oscillate at twice the stimulus frequency, indicating that signals originate...

journal_title：Neuron

authors： Benucci A,Frazor RA,Carandini M

更新日期：2007-07-05 00:00:00

abstract：:Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation. Here we consider its roles in neuronal health and disease. We review evidence from mouse knockout studies demonstrating the normal functions of autophagy as a protective factor against neurodegeneration associated with...

journal_title：Neuron

authors： Menzies FM,Fleming A,Caricasole A,Bento CF,Andrews SP,Ashkenazi A,Füllgrabe J,Jackson A,Jimenez Sanchez M,Karabiyik C,Licitra F,Lopez Ramirez A,Pavel M,Puri C,Renna M,Ricketts T,Schlotawa L,Vicinanza M,Won H,Zhu Y,

更新日期：2017-03-08 00:00:00

abstract：:In a complex nervous system, neuronal functional diversity is reflected in the wide variety of dendritic arbor shapes. Different neuronal classes are defined by class-specific transcription factor combinatorial codes. We show that the combination of the transcription factors Knot and Cut is particular to Drosophila cl...

journal_title：Neuron

authors： Jinushi-Nakao S,Arvind R,Amikura R,Kinameri E,Liu AW,Moore AW

更新日期：2007-12-20 00:00:00

abstract：:Action potentials initiate in the axon initial segment (AIS), a specialized compartment enriched with Na(+) and K(+) channels. Recently, we found that T- and R-type Ca(2+) channels are concentrated in the AIS, where they contribute to local subthreshold membrane depolarization and thereby influence action potential in...

journal_title：Neuron

authors： Bender KJ,Ford CP,Trussell LO

更新日期：2010-11-04 00:00:00

abstract：:Light plays a pivotal role in the regulation of affective behaviors. However, the precise circuits that mediate the impact of light on depressive-like behaviors are not well understood. Here, we show that light influences depressive-like behaviors through a disynaptic circuit linking the retina and the lateral habenul...

journal_title：Neuron

authors： Huang L,Xi Y,Peng Y,Yang Y,Huang X,Fu Y,Tao Q,Xiao J,Yuan T,An K,Zhao H,Pu M,Xu F,Xue T,Luo M,So KF,Ren C

更新日期：2019-04-03 00:00:00

abstract：:Astrocytes are complex bushy cells that serve important functions through close contacts between their processes and synapses. However, the spatial interactions and dynamics of astrocyte processes relative to synapses have proven problematic to study in adult living brain tissue. Here, we report a genetically targeted...

journal_title：Neuron

authors： Octeau JC,Chai H,Jiang R,Bonanno SL,Martin KC,Khakh BS

更新日期：2018-04-04 00:00:00

abstract：:Neurabin and spinophilin are homologous protein phosphatase 1 and actin binding proteins that regulate dendritic spine function. A yeast two-hybrid analysis using the coiled-coil domain of neurabin revealed an interaction with Lfc, a Rho GEF. Lfc was highly expressed in brain, where it interacted with either neurabin ...

journal_title：Neuron

authors： Ryan XP,Alldritt J,Svenningsson P,Allen PB,Wu GY,Nairn AC,Greengard P

更新日期：2005-07-07 00:00:00

abstract：:In this issue of Neuron, Wang et al. demonstrate that both cell-intrinsic and -extrinsic factors restrict the myelination of newly regenerated axons. Pharmalogical targeting of GPR17 signaling in oligodendrocyte precursor cells (OPCs) and microglial inhibition of oligodendrocyte maturation together promote robust myel...

journal_title：Neuron

authors： Hilton BJ,Bradke F

更新日期：2020-12-09 00:00:00

abstract：:We have examined the role of presynaptic residual calcium in maintaining long-term changes in synaptic efficacy observed at mossy fiber synapses between hippocampal dentate granule cells and CA3 pyramidal cells. Calcium concentrations in individual mossy fiber terminals in hippocampal slice were optically measured wit...

journal_title：Neuron

authors： Regehr WG,Tank DW

更新日期：1991-09-01 00:00:00

abstract：:We recently proposed that ciliary neurotrophic factor (CNTF) shares two receptor components with a generally acting cytokine, leukemia inhibitory factor (LIF), but that CNTF also requires a third receptor component (CNTFR alpha) that is mostly restricted to the nervous system in its expression. Here we demonstrate tha...

journal_title：Neuron

authors： Ip NY,McClain J,Barrezueta NX,Aldrich TH,Pan L,Li Y,Wiegand SJ,Friedman B,Davis S,Yancopoulos GD

更新日期：1993-01-01 00:00:00

abstract：:The Fragile X mental retardation protein (FMRP) regulates neuronal RNA metabolism, and its absence or mutations leads to the Fragile X syndrome (FXS). The β-amyloid precursor protein (APP) is involved in Alzheimer's disease, plays a role in synapse formation, and is upregulated in intellectual disabilities. Here, we s...

journal_title：Neuron

authors： Pasciuto E,Ahmed T,Wahle T,Gardoni F,D'Andrea L,Pacini L,Jacquemont S,Tassone F,Balschun D,Dotti CG,Callaerts-Vegh Z,D'Hooge R,Müller UC,Di Luca M,De Strooper B,Bagni C

更新日期：2015-07-15 00:00:00

abstract：:beta-Adrenergic receptor activation has a central role in the enhancement of memory formation that occurs during heightened states of emotional arousal. Although beta-adrenergic receptor activation may enhance memory formation by modulating long-term potentiation (LTP), a candidate synaptic mechanism involved in memor...

journal_title：Neuron

authors： Thomas MJ,Moody TD,Makhinson M,O'Dell TJ

更新日期：1996-09-01 00:00:00

abstract：:Social group dynamics are highly complex. In this issue of Neuron, Anpilov et al. use a novel wireless optogenetic device to demonstrate that the repeated stimulation of oxytocin neurons modulates pro-social and agonistic behaviors in a time- and context-dependent manner. ...

journal_title：Neuron

authors： Maltese F,Papaleo F

更新日期：2020-08-19 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key modulators of neuronal activity by providing the depolarizing cation current I(h) involved in rhythmogenesis, dendritic integration, and synaptic transmission. These tasks critically depend on the availability of HCN channels, which is dynamica...

journal_title：Neuron

authors： Zolles G,Wenzel D,Bildl W,Schulte U,Hofmann A,Müller CS,Thumfart JO,Vlachos A,Deller T,Pfeifer A,Fleischmann BK,Roeper J,Fakler B,Klöcker N

更新日期：2009-06-25 00:00:00

abstract：:Motor units comprise a pre-synaptic motor neuron and multiple post-synaptic muscle fibers. Many movement disorders disrupt motor unit contractile dynamics and the structure of sarcomeres, skeletal muscle's contractile units. Despite the motor unit's centrality to neuromuscular physiology, no extant technology can imag...

journal_title：Neuron

authors： Sanchez GN,Sinha S,Liske H,Chen X,Nguyen V,Delp SL,Schnitzer MJ

更新日期：2015-12-16 00:00:00

abstract：:Myelin ensheathes axons to allow rapid propagation of action potentials and proper nervous system function. In the peripheral nervous system, Schwann cells (SCs) radially sort axons into a 1:1 relationship before wrapping an axonal segment to form myelin. SC myelination requires the adhesion G protein-coupled receptor...

journal_title：Neuron

authors： Petersen SC,Luo R,Liebscher I,Giera S,Jeong SJ,Mogha A,Ghidinelli M,Feltri ML,Schöneberg T,Piao X,Monk KR

更新日期：2015-02-18 00:00:00

abstract：:Measuring electrical activity in large numbers of cells with high spatial and temporal resolution is a fundamental problem for the study of neural development and information processing. To address this problem, we have constructed a novel, genetically encoded probe that can be used to measure transmembrane voltage in...

journal_title：Neuron

authors： Siegel MS,Isacoff EY

更新日期：1997-10-01 00:00:00

abstract：:Historical milestones in neuroscience have come in diverse forms, ranging from the resolution of specific biological mysteries via creative experimentation to broad technological advances allowing neuroscientists to ask new kinds of questions. The continuous development of tools is driven with a special necessity by t...

journal_title：Neuron

authors： Deisseroth K,Schnitzer MJ

更新日期：2013-10-30 00:00:00

abstract：:Notch1 has been shown to induce glia in the peripheral nervous system. However, it has not been known whether Notch can direct commitment to glia from multipotent progenitors of the central nervous system. Here we present evidence that activated Notch1 and Notch3 promotes the differentiation of astroglia from the rat ...

journal_title：Neuron

authors： Tanigaki K,Nogaki F,Takahashi J,Tashiro K,Kurooka H,Honjo T

更新日期：2001-01-01 00:00:00

abstract：:Ultrasound has received widespread attention as an emerging technology for targeted, non-invasive neuromodulation based on its ability to evoke electrophysiological and motor responses in animals. However, little is known about the spatiotemporal pattern of ultrasound-induced brain activity that could drive these resp...

journal_title：Neuron

authors： Sato T,Shapiro MG,Tsao DY

更新日期：2018-06-06 00:00:00

abstract：:Primary nociceptors relay painful touch information from the periphery to the spinal cord. Although it is established that signals generated by receptor tyrosine kinases TrkA and Ret coordinate the development of distinct nociceptive circuits, mechanisms modulating TrkA or Ret pathways in developing nociceptors are un...

journal_title：Neuron

authors： Wheeler MA,Heffner DL,Kim S,Espy SM,Spano AJ,Cleland CL,Deppmann CD

更新日期：2014-05-07 00:00:00

abstract：:Regulation of synaptic strength is essential for neuronal information processing, but the molecular mechanisms that control changes in neuroexocytosis are only partially known. Here we show that the putative G protein-coupled receptor Methuselah (Mth) is required in the presynaptic motor neuron to acutely upregulate n...

journal_title：Neuron

authors： Song W,Ranjan R,Dawson-Scully K,Bronk P,Marin L,Seroude L,Lin YJ,Nie Z,Atwood HL,Benzer S,Zinsmaier KE

更新日期：2002-09-26 00:00:00