Abstract：
:Neural circadian pacemakers can be reset by light, and the resetting mechanism may involve cyclic nucleotide second messengers. We have examined pacemaker resetting and free-running activity rhythms in Drosophila dunce (dnc) and DC0 mutants, which identify a cAMP specific phosphodiesterase and the catalytic subunit of cAMP-dependent protein kinase, respectively. dnc mutants exhibit augmented light-induced phase delays and shortened circadian periods, which indicate altered pacemaker function. Interestingly, however, light-induced phase advances are normal in dnc, suggesting a selective effect on one component of the pacemaker resetting response. Furthermore, we demonstrate the presence of circadian rhythms in cAMP content in head tissues and show that dnc mutations increase the amplitude of daily cAMP peaks. These results show that cAMP levels are not chronically elevated in the dnc mutant. A role for cAMP signaling in circadian processes is also suggested by an analysis of DC0 mutants, which have severe kinase deficits and display arrhythmic locomotor activity.
journal_name
Neuronjournal_title
Neuronauthors
Levine JD,Casey CI,Kalderon DD,Jackson FRdoi
10.1016/0896-6273(94)90262-3subject
Has Abstractpub_date
1994-10-01 00:00:00pages
967-74issue
4eissn
0896-6273issn
1097-4199pii
0896-6273(94)90262-3journal_volume
13pub_type
杂志文章相关文献
NEURON文献大全abstract：:A circadian clock regulates a number of diverse physiological functions in the vertebrate eye. In this study, we show that mRNA for the red-sensitive cone pigment, iodopsin, fluctuates with a circadian rhythm in chicken retina. Transcript levels increase in the late afternoon just prior to the time of cone disc sheddi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90161-j
更新日期：1993-04-01 00:00:00
abstract：:Effective mental functioning requires that cognition be protected from emotional conflict due to interference by task-irrelevant emotionally salient stimuli. The neural mechanisms by which the brain detects and resolves emotional conflict are still largely unknown, however. Drawing on the classic Stroop conflict task,...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.07.029
更新日期：2006-09-21 00:00:00
abstract：:Sonic hedgehog (Shh) is a putative morphogen secreted by the floor plate and notochord, which specifies the fate of multiple cell types in the ventral aspect of the vertebrate nervous system. Since in Drosophila the actions of Hh have been shown to be transduced by Cubitus interruptus (Ci), a zinc finger transcription...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80344-x
更新日期：1997-07-01 00:00:00
abstract：:Within the medial frontal cortex, the supplementary eye field (SEF), supplementary motor area (SMA), and pre-SMA have been implicated in the control of voluntary action, especially during motor sequences or tasks involving rapid choices between competing response plans. However, the precise roles of these areas remain...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.05.016
更新日期：2007-06-07 00:00:00
abstract：:All sensory information is encoded in neural spike trains. It is unknown how the brain utilizes this neural code to drive behavior. Here, we unravel the decoding rules of the brain at the most elementary level by linking behavioral decisions to retinal output signals in a single-photon detection task. A transgenic mou...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.08.005
更新日期：2019-11-06 00:00:00
abstract：:I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial. Here, I(Ks) channels assembled naturally by monomer subunits are compared to those with linked subunits that force defined stoichiometries. Two strategies that exploit charybd...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00570-1
更新日期：2003-09-25 00:00:00
abstract：:Voltage-gated Na(+) channels are the workhorses of spike generation and propagation in excitable cells. Mutations in Na(+) channel genes have been identified in disorders causing episodic dysfunction of heart, skeletal muscle, and brain. Lossin and colleagues from Al George's lab report in this issue of Neuron that th...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/s0896-6273(02)00735-3
更新日期：2002-06-13 00:00:00
abstract：:Balance between excitation and inhibition (E-I balance) in neural circuits is believed to be tightly regulated. To the contrary, in this issue of Neuron, Bridi et al. (2020) reveal that inverse oscillations of synaptic inhibition and excitation lead to peaks and valleys in E-I balance across the 24 h day. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2020.01.035
更新日期：2020-02-19 00:00:00
abstract：:Attention or variations in event processing help drive learning. Lesion studies have implicated the central nucleus of the amygdala (CeA) in this process, particularly when expected rewards are omitted. However, lesion studies cannot specify how information processing in CeA supports such learning. To address these qu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.11.019
更新日期：2010-12-09 00:00:00
abstract：:Auditory information critical for fear conditioning, a model of emotional learning, is conveyed to the lateral nucleus of the amygdala via two routes: directly from the medial geniculate nucleus and indirectly from the auditory cortex. Here we show in the cortico-amygdala pathway that learned fear occludes electricall...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00645-1
更新日期：2002-04-11 00:00:00
abstract：:Neurons in LIP exhibit ramping trial-averaged responses during decision-making. Recent work sparked debate over whether single-trial LIP spike trains are better described by discrete "stepping" or continuous "ramping" dynamics. We extended latent dynamical spike train models and used Bayesian model comparison to addre...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.04.031
更新日期：2019-06-19 00:00:00
abstract：:The dopaminergic D3 receptor (D3R) is emerging as an antagonist of sensitized behavior induced by addictive drugs such as cocaine. New work by Wang and coworkers in this issue of Neuron now identifies CaMKII as an important negative regulator of the D3R. CaMKII relieves the D3R-mediated inhibition on sensitized behavi...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2009.01.025
更新日期：2009-02-12 00:00:00
abstract：:Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFR alpha), suggesting that PDGF mediates a paracrine interaction between these cells. T...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80244-5
更新日期：1996-12-01 00:00:00
abstract：:Movements are universally, sometimes frustratingly, variable. When such variability causes error, we typically assume that something went wrong during the movement. The same assumption is made by recent and influential models of motor control. These posit that the principal limit on repeatable performance is neuromusc...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.10.034
更新日期：2006-12-21 00:00:00
abstract：:Neuropilins are receptors for class 3 secreted semaphorins, most of which can function as potent repulsive axon guidance cues. We have generated mice with a targeted deletion in the neuropilin-2 (Npn-2) locus. Many Npn-2 mutant mice are viable into adulthood, allowing us to assess the role of Npn-2 in axon guidance ev...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80869-7
更新日期：2000-01-01 00:00:00
abstract：:To discover new genes involved in axon navigation, we conducted a forward genetic screen for recessive alleles affecting motor neuron pathfinding in GFP reporter mice mutagenized with ENU. In Magellan mutant embryos, motor axons were error prone and wandered inefficiently at choice points within embryos, but paradoxic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.09.009
更新日期：2007-11-21 00:00:00
abstract：:Flexible behavior in humans often requires that rapid choices be made between conflicting action plans. Although much attention has focused on prefrontal regions, little is understood about the contribution of parietal cortex under situations of response conflict. Here we show that right parietal damage associated wit...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.02.009
更新日期：2008-04-10 00:00:00
abstract：:The anterior insular cortex (AIC) and its unique spindle-shaped von Economo neuron (VEN) emerged within the last decade as having a potentially major role in self-awareness and social cognition in humans. Invasive examination of the VEN has been precluded so far by the assumption that this neuron occurs among primates...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.03.003
更新日期：2012-05-10 00:00:00
abstract：:Membrane depolarization causes voltage-gated ion channels to transition from a resting/closed conformation to an activated/open conformation. We used voltage-clamp fluorometry to measure protein motion at specific regions of the Shaker Kv channel. This enabled us to construct new structural models of the resting/close...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.09.023
更新日期：2007-10-04 00:00:00
abstract：:beta-Adrenergic receptor activation has a central role in the enhancement of memory formation that occurs during heightened states of emotional arousal. Although beta-adrenergic receptor activation may enhance memory formation by modulating long-term potentiation (LTP), a candidate synaptic mechanism involved in memor...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80179-8
更新日期：1996-09-01 00:00:00
abstract：:A multitude of synaptic proteins interact at the active zones of nerve terminals to achieve the high temporal precision of neurotransmitter release in synchrony with action potentials. Though synaptotagmin has been recognized as the Ca2+ sensor for synchronous release, it may have additional roles of action. We addres...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.07.028
更新日期：2009-08-27 00:00:00
abstract：:Recent studies indicate that dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we comprehensively identified each area's monosynaptic inputs using the rabies virus. We show that dopamine neurons in both areas integrate inp...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.03.017
更新日期：2012-06-07 00:00:00
abstract：:Mammalian olfactory sensory neurons that express a particular odorant receptor (OR) project axons to the same few glomeruli in the olfactory bulb. In this issue of Neuron, Vassalli et al. use OR minigenes that coexpress histochemical markers and show that the determinants in the sensory neurons required to generate th...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(02)00831-0
更新日期：2002-08-15 00:00:00
abstract：:Identifying the spatial organization of tissues at cellular resolution from single-cell gene expression profiles is essential to understanding biological systems. Using an in situ 3D multiplexed imaging method, seqFISH, we identify unique transcriptional states by quantifying and clustering up to 249 genes in 16,958 c...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.10.001
更新日期：2016-10-19 00:00:00
abstract：:The alpha subunit of a voltage-sensitive sodium channel characteristic of denervated rat skeletal muscle was cloned and characterized. The cDNA encodes a 2018 amino acid protein (SkM2) that is homologous to other recently cloned sodium channels, including a tetrodotoxin (TTX)-sensitive sodium channel from rat skeletal...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90098-z
更新日期：1990-02-01 00:00:00
abstract：:The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we exami...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.12.025
更新日期：2006-02-16 00:00:00
abstract：:Proteolipid protein (PLP) is an integral membrane protein of CNS myelin. Mutations of the X chromosome-linked PLP gene cause glial cell death and myelin deficiency in jimpy mice and other neurological mutants. As part of an attempt to rescue these mutants by transgenic complementation, we generated normal mouse lines ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90214-3
更新日期：1994-03-01 00:00:00
abstract：:In this issue of Neuron, Wahl et al. demonstrate via invasive recordings from Deep Brain Stimulation leads that the thalamus (but not basal ganglia) is sensitive to certain linguistic violations, consistent with a subcortical role in selective recruitment of language-related cortical areas. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2008.08.015
更新日期：2008-09-11 00:00:00
abstract：:NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor-expressing cells, and the majority of native receptors are triheteromers containing two GluN1 and two different GluN2. In contrast to diheterome...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.01.035
更新日期：2014-03-05 00:00:00
abstract：:The regulation of quantal size through pre- rather than postsynaptic mechanisms has recently received considerable attention as a potential mechanism for plasticity. Vesicular transporters catalyze the filling of synaptic vesicles with transmitter and are thus potential substrates for such presynaptic regulation. In t...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2006.08.019
更新日期：2006-09-07 00:00:00
