Abstract：
:Sonic hedgehog (Shh) is a putative morphogen secreted by the floor plate and notochord, which specifies the fate of multiple cell types in the ventral aspect of the vertebrate nervous system. Since in Drosophila the actions of Hh have been shown to be transduced by Cubitus interruptus (Ci), a zinc finger transcription factor, we examined whether a vertebrate homolog of this protein can mediate the functions of Shh in the vertebrate nervous system. Here, we demonstrate that expression of Gli-1, one of three vertebrate homologs of Ci, can be induced by Shh in the neural tube. Further, ectopic expression of Gli-1 in the dorsal midbrain and hindbrain of transgenic mice mimics the effects of ectopically expressed Shh-N, leading to the activation of ventral neural tube markers such as Ptc, HNF-3beta, and Shh; to the suppression of dorsal markers such as Pax-3 and AL-1; and to the formation of ectopic dorsal clusters of dopaminergic and serotonergic neurons. These findings demonstrate that GLI-1 can reproduce the cell patterning actions of Shh in the developing nervous system and provide support for the hypothesis that it is a mediator of the Shh signal in vertebrates.
journal_name
Neuronjournal_title
Neuronauthors
Hynes M,Stone DM,Dowd M,Pitts-Meek S,Goddard A,Gurney A,Rosenthal Adoi
10.1016/s0896-6273(00)80344-xsubject
Has Abstractpub_date
1997-07-01 00:00:00pages
15-26issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80344-Xjournal_volume
19pub_type
杂志文章相关文献
NEURON文献大全abstract：:Both the sec6/8 complex and septin filaments have been implicated in directing vesicles and proteins to sites of active membrane addition in yeast. The rat brain sec6/8 complex coimmunoprecipitates with a filament composed of four mammalian septins, suggesting an interaction between these complexes. One of the septins...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80493-6
更新日期：1998-06-01 00:00:00
abstract：:The size of the movement and the molecular identity of the moving parts of the voltage sensor of a voltage-gated ion channel are debated. In the helical-screw model, the positively charged fourth transmembrane segment S4 slides and rotates along negative counter charges in S2 and S3, while in the paddle model, S4 carr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.07.008
更新日期：2008-09-11 00:00:00
abstract：:GABARAP recognizes and binds the gamma2 subunit of the GABA(A) receptor, interacts with microtubules and the N-ethyl maleimide sensitive factor, and is proposed to function in GABA(A) receptor trafficking and postsynaptic localization. We have determined the crystal structure of human GABARAP at 1.6 A resolution. The ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00558-x
更新日期：2002-01-03 00:00:00
abstract：:The process by which neural circuitry in the brain plans and executes movements is not well understood. Until recently, most available data were limited either to single-neuron electrophysiological recordings or to measures of aggregate field or metabolism. Neither approach reveals how individual neurons' activities a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.05.047
更新日期：2011-08-11 00:00:00
abstract：:Simultaneous somatic and dendritic recordings were made from the same neocortical layer V pyramidal neuron, and current injection via the dendritic recording pipette was used to simulate the voltage change that occurs during an EPSP. At the soma, these simulated EPSPs increased nonlinearly with the amplitude of the de...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90095-0
更新日期：1995-11-01 00:00:00
abstract：:For efficient coding, sensory systems need to adapt to the distribution of signals to which they are exposed. In vision, natural scenes above and below the horizon differ in the distribution of chromatic and achromatic features. Consequently, many species differentially sample light in the sky and on the ground using ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.09.030
更新日期：2013-12-04 00:00:00
abstract：:A circadian clock governs most aspects of mammalian behavior. Although its properties are in part genetically determined, altered light-dark environment can change circadian period length through a mechanism requiring de novo DNA methylation. We show here that this mechanism is mediated not via cell-autonomous clock p...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.12.022
更新日期：2017-01-18 00:00:00
abstract：:We have cloned the rat gene encoding peripherin, a neuronal-specific intermediate filament protein that is NGF-regulated. Determination of the complete sequence, including 821 nucleotides of the 5'-flanking region, allows us to make conclusions about the evolutionary origin of the peripherin gene, its homology with ot...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(89)90228-6
更新日期：1989-01-01 00:00:00
abstract：:Spine Ca(2+) is critical for the induction of synaptic plasticity, but the factors that control Ca(2+) handling in dendritic spines under physiological conditions are largely unknown. We studied [Ca(2+)] signaling in dendritic spines of CA1 pyramidal neurons and find that spines are specialized structures with low end...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00573-1
更新日期：2002-01-31 00:00:00
abstract：:Adjustments in neural activity can drive cortical plasticity, but the underlying circuit components remain unclear. In this issue of Neuron, Barnes et al. (2015) show that visual deprivation-induced homeostatic plasticity invokes specific changes among select categories of V1 neurons. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2015.05.039
更新日期：2015-06-03 00:00:00
abstract：:A new study by Yao et al. in the current issue of Cell proposes that a novel vesicular protein, dubbed Flower, regulates endocytosis by controlling presynaptic Ca(2+) levels. This finding is intriguing not only for its implications for vesicle cycling, but also for the multitude of Ca(2+)-dependent processes at play i...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.08.031
更新日期：2009-09-10 00:00:00
abstract：:A circadian clock regulates a number of diverse physiological functions in the vertebrate eye. In this study, we show that mRNA for the red-sensitive cone pigment, iodopsin, fluctuates with a circadian rhythm in chicken retina. Transcript levels increase in the late afternoon just prior to the time of cone disc sheddi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90161-j
更新日期：1993-04-01 00:00:00
abstract：:Cognitive maps are encoded in the hippocampal formation and related regions and range from the spatial to the purely conceptual. Neural mechanisms that encode information into relational structures, up to an arbitrary level of abstraction, may explain such a broad range of representation. Research now indicates that s...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2018.10.006
更新日期：2018-10-24 00:00:00
abstract：:In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP)...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00465-3
更新日期：2003-08-28 00:00:00
abstract：:To survive, humans must estimate their own ability and the abilities of others. We found that, although people estimated their abilities on the basis of their own performance in a rational manner, their estimates of themselves were partly merged with the performance of others. Reciprocally, their ability estimates for...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.06.022
更新日期：2016-07-20 00:00:00
abstract：:In this issue of Neuron, Kupferschmidt et al. (2017) reveal the shifting dynamics of functionally defined corticostriatal pathways during skill learning in mice using fiber photometry. They show different time courses in plasticity of associative and sensorimotor circuits across learning that involve changes at both t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.09.046
更新日期：2017-10-11 00:00:00
abstract：:Historically, the rat has been the preferred animal model for behavioral studies. Limitations in genome modification have, however, caused a lag in their use compared to the bevy of available transgenic mice. Here, we have developed several transgenic tools, including viral vectors and transgenic rats, for targeted ge...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.01.035
更新日期：2019-04-03 00:00:00
abstract：:Functional PNS regeneration requires injured axons to return to their original synaptic targets, yet the mechanisms underlying target-selective regeneration have remained elusive. Using live-cell imaging in zebrafish we find that regenerating motor axons exhibit a strong preference for their original muscle territory ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.10.004
更新日期：2015-11-18 00:00:00
abstract：:Terminal Schwann cells overlying the neuromuscular junction sprout elaborate processes upon muscle denervation. We show here that motor axons use these processes as guides/substrates during regeneration; in so doing, they escape the confines of endplates and grow between endplates to generate polyneuronal innervation....
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90246-5
更新日期：1995-01-01 00:00:00
abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder with no known cure. The etiology of PD is likely due, in part, to combinations of genetic susceptibilities and environmental factors. In rare familial cases, PD is due to genetic mutations. A number of new genetic and toxin models of PD and advances in ol...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(02)00780-8
更新日期：2002-07-18 00:00:00
abstract：:Proper mRNA quality control prevents immune activation; when it goes awry, mice and flies develop abnormal behavioral phenotypes. In this issue of Neuron, Johnson et al. (2019) report that inhibiting nonsense-mediated mRNA decay (NMD) contributes to the pathogenesis of neurodevelopmental disorder (NDD) phenotypes by t...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2019.10.042
更新日期：2019-11-20 00:00:00
abstract：:Pletikos et al. (2014) demonstrate in this issue of Neuron that the human neocortex has an "hourglass" temporal gene expression pattern with robust and dynamic transcriptome differences during the prenatal and adolescent/adult periods. Similar changes are not observed in the nonhuman primate-is this what makes us huma...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2014.01.006
更新日期：2014-01-22 00:00:00
abstract：:The time course and functional significance of the structural changes associated with long-term facilitation of Aplysia sensory to motor neuron synaptic connections in culture were examined by time-lapse confocal imaging of individual sensory neuron varicosities labeled with three different fluorescent markers: the wh...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00595-6
更新日期：2003-09-25 00:00:00
abstract：:In the hippocampus, gamma power modulation by the theta rhythm is interpreted as the signature of temporally coordinated inputs that reflect ongoing processing. In this issue of Neuron, Lopes-Dos-Santos et al. (2018) develop a new methodology demonstrating that theta cycles can be viewed as individual computational un...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.11.008
更新日期：2018-11-21 00:00:00
abstract：:The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a variety of task-related signals have been observed in the PFC, whether they are differentially encoded by various cell types remains unclear. Here we performed cellular-resolution microendoscopic Ca(2+) imaging from genetica...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.06.021
更新日期：2015-07-15 00:00:00
abstract：:In this issue of Neuron, Kremeyer et al. describe a gain-of-function mutation of TRPA1 that produces a painful disorder, familial episodic pain syndrome. This discovery enlarges the list of ion channels that, when mutated, produce pain. The growing universe of "channelopathic pain" presents some interesting overarchin...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2010.05.029
更新日期：2010-06-10 00:00:00
abstract：:Neuronal development is characterized by a period of exuberant synaptic growth that is well studied. However, the mechanisms that restrict this process are less clear. Here we demonstrate that glycosylphosphatidylinositol-anchored cell-surface receptors of the Nogo Receptor family (NgR1, NgR2, and NgR3) restrict excit...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.11.029
更新日期：2012-02-09 00:00:00
abstract：:Sensory experience evokes long-lasting changes in neural circuits through activity-dependent gene expression. Ataman et al. (2016) report in Nature that primates evolved novel transcriptional responses to neuronal activity, including induction of musclin/osteocrin (OSTN), which may regulate specialized aspects of prim...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.11.024
更新日期：2016-11-23 00:00:00
abstract：:The Fragile X mental retardation-1 (Fmr1) gene encodes a multifunctional protein, FMRP, with intrinsic RNA binding activity. We have developed an approach, antibody-positioned RNA amplification (APRA), to identify the RNA cargoes associated with the in vivo configured FMRP messenger ribonucleoprotein (mRNP) complex. U...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00034-5
更新日期：2003-02-06 00:00:00
abstract：:In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.04.034
更新日期：2016-06-01 00:00:00
