Global control of motor neuron topography mediated by the repressive actions of a single hox gene.

abstract：:Attention or variations in event processing help drive learning. Lesion studies have implicated the central nucleus of the amygdala (CeA) in this process, particularly when expected rewards are omitted. However, lesion studies cannot specify how information processing in CeA supports such learning. To address these qu...

journal_title：Neuron

authors： Calu DJ,Roesch MR,Haney RZ,Holland PC,Schoenbaum G

更新日期：2010-12-09 00:00:00

abstract：:Ultra-slow, ∼0.1-Hz variations in the oxygenation level of brain blood are widely used as an fMRI-based surrogate of "resting-state" neuronal activity. The temporal correlations among these fluctuations across the brain are interpreted as "functional connections" for maps and neurological diagnostics. Ultra-slow varia...

journal_title：Neuron

authors： Drew PJ,Mateo C,Turner KL,Yu X,Kleinfeld D

更新日期：2020-09-09 00:00:00

abstract：:Modification of AMPA receptor function is a major mechanism for the regulation of synaptic transmission and underlies several forms of synaptic plasticity. Post-translational palmitoylation is a reversible modification that regulates localization of many proteins. Here, we report that palmitoylation of the AMPA recept...

journal_title：Neuron

authors： Hayashi T,Rumbaugh G,Huganir RL

更新日期：2005-09-01 00:00:00

abstract：:Synapse-to-nucleus signaling leading to CREB-mediated transcription is important for neuronal plasticity. Nuclear CREB phosphorylation at Ser133 allows convergence of multiple kinase pathways driven by neuronal activity and links them to transcriptional activation. But, can various pathways share a common effector mec...

journal_title：Neuron

authors： Deisseroth K,Tsien RW

更新日期：2002-04-11 00:00:00

abstract：:Cytokines are pleotrophic proteins that coordinate the host response to infection as well as mediate normal, ongoing signaling between cells of nonimmune tissues, including the nervous system. As a consequence of this dual role, cytokines induced in response to maternal infection or prenatal hypoxia can profoundly imp...

journal_title：Neuron

authors： Deverman BE,Patterson PH

更新日期：2009-10-15 00:00:00

abstract：:How does the noradrenergic nucleus locus coeruleus act on target networks to regulate behavior? In this issue of Neuron, Zerbi et al. (2019) combine functional neuroimaging and pharmacogenetics in mice to tackle that question, uncovering a network action underlying stress. And providing insight for cognition? ...

journal_title：Neuron

authors： Bouret S

更新日期：2019-08-21 00:00:00

abstract：:To identify the molecular mechanisms underlying psychostimulant-elicited plasticity in the brain reward system, we undertook a phenotype-driven approach using genome-wide microarray profiling of striatal transcripts from three genetic and one pharmacological mouse models of psychostimulant or dopamine supersensitivity...

journal_title：Neuron

authors： Yao WD,Gainetdinov RR,Arbuckle MI,Sotnikova TD,Cyr M,Beaulieu JM,Torres GE,Grant SG,Caron MG

更新日期：2004-02-19 00:00:00

abstract：:The eye often leads the way in the development of novel strategies for treating neurodegenerative disorders. Here, we highlight an exciting new study examining the potential for reactivating endogenous repair mechanisms and enabling the mammalian retina to repair itself. ...

journal_title：Neuron

authors： Pearson RA,Ali RR

更新日期：2018-11-07 00:00:00

abstract：:Inflammatory mediators act on peripheral sensory neurons to produce pain and hypersensitivity after tissue injury. In this issue of Neuron, Dina et al. report that inflammatory mediators, such as epinephrine and prostaglandins, appear to couple to specific G protein-coupled receptor signaling pathways through plastic ...

journal_title：Neuron

authors： Bhave G,Gereau RW 4th

更新日期：2003-08-14 00:00:00

abstract：:Spinal and bulbar muscular atrophy (SBMA) is a polyglutamine disease caused by the expansion of a CAG repeat in the androgen receptor (AR) gene. We generated a transgenic mouse model carrying a full-length AR containing 97 CAGs. Three of the five lines showed progressive muscular atrophy and weakness as well as diffus...

journal_title：Neuron

authors： Katsuno M,Adachi H,Kume A,Li M,Nakagomi Y,Niwa H,Sang C,Kobayashi Y,Doyu M,Sobue G

更新日期：2002-08-29 00:00:00

abstract：:Previous research suggests that synchronous neural activity underlies perceptual grouping of visual image features. The generality of this mechanism is unclear, however, as previous studies have focused on pairs of neurons with overlapping or collinear receptive fields. By sampling more broadly and employing stimuli t...

journal_title：Neuron

authors： Palanca BJ,DeAngelis GC

更新日期：2005-04-21 00:00:00

abstract：:Activity is known to be important for the refinement of neural connections in the developing brain. In this issue of Neuron, Hanson and Landmesser provide evidence that GABA-dependent spontaneous bursting of motor neurons in the embryonic spinal cord is required for the correct execution of an early axon pathfinding d...

journal_title：Neuron

authors： Goulding M

更新日期：2004-09-02 00:00:00

abstract：:Gamma-frequency oscillations (GFOs, >40 Hz) are a general network signature at seizure onset at all stages of development, with possible deleterious consequences in the immature brain. At early developmental stages, the simultaneous occurrence of GFOs in different brain regions suggests the existence of a long-ranging...

journal_title：Neuron

authors： Quilichini PP,Le Van Quyen M,Ivanov A,Turner DA,Carabalona A,Gozlan H,Esclapez M,Bernard C

更新日期：2012-04-12 00:00:00

abstract：:The physiological role of BDNF and NT-3 in the development of the vestibular and auditory systems was investigated in mice that carry a deleted BDNF and/or NT-3 gene. BDNF was the major survival factor for vestibular ganglion neurons, and NT-3, for spiral ganglion neurons. Lack of BDNF and NT-3 did not affect ingrowth...

journal_title：Neuron

authors： Ernfors P,Van De Water T,Loring J,Jaenisch R

更新日期：1995-06-01 00:00:00

abstract：:Carbon monoxide (CO) induces a long-lasting alteration in cerebellar alpha 3-Na,K-ATPase independent of [Na+] but linked to cGMP synthesis and localized to Purkinje neurons. The action of CO is absent in Purkinje neuron-deficient mice, mimicked by 8-Br-cGMP, and blocked by inhibition of PKG. Glutamate (Glu) and metabo...

journal_title：Neuron

authors： Nathanson JA,Scavone C,Scanlon C,McKee M

更新日期：1995-04-01 00:00:00

abstract：:A circadian clock governs most aspects of mammalian behavior. Although its properties are in part genetically determined, altered light-dark environment can change circadian period length through a mechanism requiring de novo DNA methylation. We show here that this mechanism is mediated not via cell-autonomous clock p...

journal_title：Neuron

authors： Azzi A,Evans JA,Leise T,Myung J,Takumi T,Davidson AJ,Brown SA

更新日期：2017-01-18 00:00:00

abstract：:The mechanism of kainate receptor targeting and clustering is still unresolved. Here, we demonstrate that members of the SAP90/PSD-95 family colocalize and associate with kainate receptors. SAP90 and SAP102 coimmunoprecipitate with both KA2 and GluR6, but only SAP97 coimmunoprecipitates with GluR6. Similar to NMDA rec...

journal_title：Neuron

authors： Garcia EP,Mehta S,Blair LA,Wells DG,Shang J,Fukushima T,Fallon JR,Garner CC,Marshall J

更新日期：1998-10-01 00:00:00

abstract：:Opioids are commonly used as analgesics for severe pain, but their addictive potential has sparked a misuse epidemic. In this issue of Neuron, Keyes et al. (2020) examine the contributions of distinct paraventricular thalamus (PVT) outputs to contextual opioid memories. They identify a PVT→NAc→LH circuit essential for...

journal_title：Neuron

authors： Pribiag H,Lim BK

更新日期：2020-09-23 00:00:00

abstract：:Acetylcholinesterase (AChE) is concentrated at the vertebrate neuromuscular synapse. To determine whether increased transcript levels could underlie this selective accumulation, we employed a quantitative reverse transcription polymerase chain reaction-based assay to determine mRNA copy number in samples as small as s...

journal_title：Neuron

authors： Jasmin BJ,Lee RK,Rotundo RL

更新日期：1993-09-01 00:00:00

abstract：:Neuronal activity-dependent processes are believed to mediate the formation of synaptic connections during neocortical development, but the underlying intracellular mechanisms are not known. In the visual system, altering the pattern of visually driven neuronal activity by monocular deprivation induces cortical synapt...

journal_title：Neuron

authors： Pham TA,Impey S,Storm DR,Stryker MP

更新日期：1999-01-01 00:00:00

abstract：:Recently, we found that electrical stimulation of motor cortex caused monkeys to make coordinated, complex movements. These evoked movements were arranged across the cortex in a map of spatial locations to which the hand moved. We suggest that some of the subdivisions previously described within primary motor and prem...

journal_title：Neuron

authors： Graziano MS,Taylor CS,Moore T,Cooke DF

更新日期：2002-10-24 00:00:00

abstract：:We have studied the subcellular distribution of the alpha 1 and alpha 2 subunits of the dihydropyridine (DHP) receptor and ankyrin in rat skeletal muscle with immunofluorescence and immunogold labeling techniques. All three proteins were concentrated in the triad junction formed between the T-tubules and sarcoplasmic ...

journal_title：Neuron

authors： Flucher BE,Morton ME,Froehner SC,Daniels MP

更新日期：1990-09-01 00:00:00

abstract：:M-current is widespread in the nervous system. It stabilizes cell excitability, and its suppression by muscarinic receptor activation underlies slow synaptic transmission in sympathetic neurons. Suppression of M-current was one of the first examples of neuromodulation of a potassium current, but the mechanism is not u...

journal_title：Neuron

authors： Marrion NV

更新日期：1993-07-01 00:00:00

abstract：:The neonatal mammal faces an array of sensory stimuli when diverse neuronal types have yet to form sensory maps. How these inputs interact with intrinsic neuronal activity to facilitate circuit assembly is not well understood. By using longitudinal calcium imaging in unanesthetized mouse pups, we show that layer I (LI...

journal_title：Neuron

authors： Che A,Babij R,Iannone AF,Fetcho RN,Ferrer M,Liston C,Fishell G,De Marco García NV

更新日期：2018-07-11 00:00:00

abstract：:Slob is a novel protein that binds to the carboxy-terminal domain of the Drosophila Slowpoke (dSlo) calcium-dependent potassium (K(Ca)) channel. A yeast two-hybrid screen with Slob as bait identifies the zeta isoform of 14-3-3 as a Slob-binding protein. Coimmunoprecipitation experiments from Drosophila heads and trans...

journal_title：Neuron

authors： Zhou Y,Schopperle WM,Murrey H,Jaramillo A,Dagan D,Griffith LC,Levitan IB

更新日期：1999-04-01 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, ...

journal_title：Neuron

authors： Albouy G,Sterpenich V,Balteau E,Vandewalle G,Desseilles M,Dang-Vu T,Darsaud A,Ruby P,Luppi PH,Degueldre C,Peigneux P,Luxen A,Maquet P

更新日期：2008-04-24 00:00:00

abstract：:The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors and chromatin are thought to regulate gene expression. In the medial ganglionic eminence, the NKX2-1 transcription factor controls regional id...

journal_title：Neuron

authors： Sandberg M,Flandin P,Silberberg S,Su-Feher L,Price JD,Hu JS,Kim C,Visel A,Nord AS,Rubenstein JLR

更新日期：2016-09-21 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) have long been associated with proliferation in non-neural cells, although they are also expressed in postmitotic neurons. We demonstrate that insulin-like growth factor-1 (IGF-1) induces within seconds a large, tyrosine-kinase-dependent increase in calcium channel currents in cerebell...

journal_title：Neuron

authors： Blair LA,Marshall J

更新日期：1997-08-01 00:00:00

abstract：:Brain function is mediated by neural circuit connectivity, and elucidating the role of connections is aided by techniques to block their output. We developed cell-type-selective, reversible synaptic inhibition tools for mammalian neural circuits by leveraging G protein signaling pathways to suppress synaptic vesicle r...

journal_title：Neuron

authors： Stachniak TJ,Ghosh A,Sternson SM

更新日期：2014-05-21 00:00:00

abstract：:Coordination between sequential steps in synaptic vesicle endocytosis, including clathrin coat formation, fission, and uncoating, appears to involve proteinprotein interactions. Here, we show that compounds that disrupt interactions of the SH3 domain of endophilin with dynamin and synaptojanin impair synaptic vesicle ...

journal_title：Neuron

authors： Gad H,Ringstad N,Löw P,Kjaerulff O,Gustafsson J,Wenk M,Di Paolo G,Nemoto Y,Crun J,Ellisman MH,De Camilli P,Shupliakov O,Brodin L

更新日期：2000-08-01 00:00:00