Abstract：
:Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission, induces synaptic plasticity, and coordinates firing of groups of neurons. As a result, it changes the state of neuronal networks throughout the brain and modifies their response to internal and external inputs: the classical role of a neuromodulator. Here, we identify actions of cholinergic signaling on cellular and synaptic properties of neurons in several brain areas and discuss consequences of this signaling on behaviors related to drug abuse, attention, food intake, and affect. The diverse effects of acetylcholine depend on site of release, receptor subtypes, and target neuronal population; however, a common theme is that acetylcholine potentiates behaviors that are adaptive to environmental stimuli and decreases responses to ongoing stimuli that do not require immediate action. The ability of acetylcholine to coordinate the response of neuronal networks in many brain areas makes cholinergic modulation an essential mechanism underlying complex behaviors.
journal_name
Neuronjournal_title
Neuronauthors
Picciotto MR,Higley MJ,Mineur YSdoi
10.1016/j.neuron.2012.08.036subject
Has Abstractpub_date
2012-10-04 00:00:00pages
116-29issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(12)00802-1journal_volume
76pub_type
杂志文章,评审相关文献
NEURON文献大全abstract：:In this issue of Neuron, Rinberg et al. show that mice use a speed-accuracy tradeoff in odor discrimination. Shorter sampling results in high performance for easy problems, and enforced longer sampling results in higher accuracy for difficult problems, but mice freely choose intermediate sampling durations and accurac...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2006.07.015
更新日期：2006-08-03 00:00:00
abstract：:Memory decline in aging results from multiple factors that influence both executive function and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems are preferentially vulnerable to white matter change, atrophy, and certain forms of neurotransmitter depletion. Frontal-striatal change ma...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2004.09.006
更新日期：2004-09-30 00:00:00
abstract：:Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields have been combined only recently to facilitate novel experiments and measurements in neuroscience. Since tissue-clearing methods were first combined with modernized light-sheet microscopy a decade ago, the performance of both tec...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2020.03.004
更新日期：2020-05-06 00:00:00
abstract：:The role of early visual experience in the establishment of human high-order visual areas is poorly understood. Here we investigated this issue using human amblyopia--a developmental visual disorder, which manifests a central vision (acuity) deficit. Previous fMRI studies of amblyopes have described abnormal functiona...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00720-7
更新日期：2003-12-04 00:00:00
abstract：:Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.07.037
更新日期：2013-09-18 00:00:00
abstract：:Involvement of the cAMP cascade in Drosophila learning and memory is suggested by the aberrant behavioral phenotypes of the mutants dunce (cAMP phosphodiesterase) and rutabaga (adenylyl cyclase). Line DCO581, isolated via an enhancer detector screen for genes preferentially expressed in the mushroom bodies, contains a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90178-t
更新日期：1993-08-01 00:00:00
abstract：:Both the sec6/8 complex and septin filaments have been implicated in directing vesicles and proteins to sites of active membrane addition in yeast. The rat brain sec6/8 complex coimmunoprecipitates with a filament composed of four mammalian septins, suggesting an interaction between these complexes. One of the septins...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80493-6
更新日期：1998-06-01 00:00:00
abstract：:The enteric nervous system (ENS) in vertebrates is derived mainly from vagal neural crest cells that enter the foregut and colonize the entire wall of the gastrointestinal tract. Failure to completely colonize the gut results in the absence of enteric ganglia (Hirschsprung's disease). Two signaling systems mediated by...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00730-x
更新日期：2003-12-04 00:00:00
abstract：:Changes in social preference of amphibian larvae result from sustained exposure to kinship odorants. To understand the molecular and cellular mechanisms of this neuroplasticity, we investigated the effects of olfactory system activation on neurotransmitter (NT) expression in accessory olfactory bulb (AOB) interneurons...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.08.023
更新日期：2017-09-13 00:00:00
abstract：:Whether cognitive representations are better conceived as language-based, symbolic representations or perceptually related, analog representations is a subject of debate. If cognitive processes parallel perceptual processes, then fundamental psychophysical laws should hold for each. To test this, we analyzed both beha...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/s0896-6273(02)01144-3
更新日期：2003-01-09 00:00:00
abstract：:Olfaction is a vitally important sense for all animals. There are striking similarities between species in the organization of the olfactory pathway, from the nature of the odorant receptor proteins, to perireceptor processes, to the organization of the olfactory CNS, through odor-guided behavior and memory. These com...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2005.10.022
更新日期：2005-11-03 00:00:00
abstract：:The brain is a vulnerable metabolic organ and must adapt to different fuel conditions to sustain function. Nerve terminals are a locus of this vulnerability, but how they regulate ATP synthesis as fuel conditions vary is unknown. We show that synapses can switch from glycolytic to oxidative metabolism, but to do so, t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.11.020
更新日期：2020-02-19 00:00:00
abstract：:To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00682-2
更新日期：2003-10-30 00:00:00
abstract：:The state of the brain and body constantly varies on rapid and slow timescales. These variations contribute to the apparent noisiness of sensory responses at both the neural and the behavioral level. Recent investigations of rapid state changes in awake, behaving animals have provided insight into the mechanisms by wh...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2015.09.012
更新日期：2015-09-23 00:00:00
abstract：:Much is known about the functions and properties of neuronal dendrites, but rarely has dendritic activation been monitored while the dendrite performs a computational task. In this issue of Neuron, Bollmann and Engert demonstrate that different regions of a dendrite in the tadpole optic tectum are tuned to stimuli in ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2009.03.009
更新日期：2009-03-26 00:00:00
abstract：:Cognitive deficits, core features of mental illness, largely result from dysfunction of prefrontal networks. This dysfunction emerges during early development, before a detectable behavioral readout, yet the cellular elements controlling the abnormal maturation are still unknown. Here, we address this open question by...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.09.042
更新日期：2020-01-08 00:00:00
abstract：:How does a visual search goal modulate the activity of neurons encoding different visual features (e.g., color, direction of motion)? Previous research suggests that goal-driven attention enhances the gain of neurons representing the target's visual features. Here, we present mathematical and behavioral evidence that ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.01.018
更新日期：2007-02-15 00:00:00
abstract：:The activation of light-dependent K+ channels in ciliary photoreceptors from Pecten was investigated using intracellular dialysis of putative messengers and modulators. Neither elevated [Ca2+] nor BAPTA changed the membrane current in the dark or the light response. IP3 and the antagonists heparin and decavanadate wer...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90149-3
更新日期：1995-09-01 00:00:00
abstract：:Amphetamine (AMPH) releases monoamines, transiently stimulates locomotion, and inhibits feeding. Using a genetic approach, we show that mice lacking dopamine (DA-deficient, or DD, mice) are resistant to the hypophagic effects of a moderate dose of AMPH (2 microg/g) but manifest normal AMPH-induced hypophagia after res...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.10.009
更新日期：2004-10-28 00:00:00
abstract：:In a complex nervous system, neuronal functional diversity is reflected in the wide variety of dendritic arbor shapes. Different neuronal classes are defined by class-specific transcription factor combinatorial codes. We show that the combination of the transcription factors Knot and Cut is particular to Drosophila cl...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.10.031
更新日期：2007-12-20 00:00:00
abstract：:The visual cortex has the capacity for experience-dependent change, or cortical plasticity, that is retained throughout life. Plasticity is invoked for encoding information during perceptual learning, by internally representing the regularities of the visual environment, which is useful for facilitating intermediate-l...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.06.030
更新日期：2012-07-26 00:00:00
abstract：:Much evidence indicates that prefrontal cortex plays an important role in long-term recognition memory processes. Here, we report primate prefrontal neuronal responses carrying information necessary for long-term visual recognition memory. The responses of many neurons signaled stimulus familiarity even when the perio...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.05.013
更新日期：2004-06-10 00:00:00
abstract：:For the past 60 years, the central nervous system has been considered immunologically privileged. Yet results from diverse fields show clear and convincing evidence of bidirectional communication between the nervous and immune systems. ...
journal_title：Neuron
pub_type：
doi：10.1016/j.neuron.2009.09.038
更新日期：2009-10-15 00:00:00
abstract：:Pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. Although tau aggregation is associated with abnormal tau phosphorylation, the role of phosphorylation in the initiation of neurodegeneration has been unclear. Now, several animal models and data f...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(03)00681-0
更新日期：2003-10-30 00:00:00
abstract：:We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the association between the disorder and chromosomal copy number (CNV) burden. We combined data from 5,745 cases and 10,675 controls with other published datasets containing genome-wide CNV data. In this much-enlarged sample of 11,355 cas...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.04.022
更新日期：2015-06-03 00:00:00
abstract：:Primates with long-standing therapeutic amputations of a limb at a young age were used to investigate the possibility that deefferented motor nerves sprout to new muscle targets. Injections of anatomical tracers into the muscles proximal to the amputated stump labeled a larger extent of motoneurons than matched inject...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)00167-7
更新日期：2000-12-01 00:00:00
abstract：:Neuronal cell migration in the developing neocortex relies on the Reelin signaling cascade to establish the characteristic "inside out" lamination pattern. In this issue of Neuron, Rakic and colleagues report that Notch signaling, long known to regulate neural stem cells, also plays a critical role in mediating the ef...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2008.10.009
更新日期：2008-10-23 00:00:00
abstract：:The fidelity with which spinal motor neurons innervate their limb target muscles helps to coordinate motor behavior, but the mechanisms that determine precise patterns of nerve-muscle connectivity remain obscure. We show that Nkx6 proteins, a set of Hox-regulated homeodomain transcription factors, are expressed by mot...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.11.033
更新日期：2008-01-24 00:00:00
abstract：:Opioid neuropeptides and their receptors are evolutionarily conserved neuromodulatory systems that profoundly influence behavior. In dorsal striatum, which expresses the endogenous opioid enkephalin, patches (or striosomes) are limbic-associated subcompartments enriched in mu opioid receptors. The functional implicati...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.11.010
更新日期：2015-12-16 00:00:00
abstract：:Particle-mediated gene transfer and two-photon microscopy were used to monitor the behavior of dendrites of individual cortical pyramidal neurons coexpressing green fluorescent protein (GFP) and brain-derived neurotrophic factor (BDNF). While the dendrites and spines of neurons expressing GFP alone grew modestly over ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80785-0
更新日期：1999-06-01 00:00:00
