Abstract：
:Cortical synaptic circuitry develops rapidly in the second postnatal week, simultaneous with experience-dependent turnover of dendritic spines. To relate the emergence of sensory maps to synaptogenesis, we recorded synaptic potentials evoked by whisker deflection in layer 2/3 neurons from postnatal day (P) 12 to 20. At P12, synaptic responses were undetectable. Only 2 days later in life (P14), receptive fields had mature organization. Sensory deprivation, if initiated before P14, disrupted receptive field structure. In layer 4, responses and maps were already mature by P12 and insensitive to deprivation, implying that barrel cortex develops from layer 4 to layer 2/3. Thus, P12-14 is a critical period shared by layer 2/3 synapses and their spines, suggesting that spine plasticity is involved in the refinement of maps.
journal_name
Neuronjournal_title
Neuronauthors
Stern EA,Maravall M,Svoboda Kdoi
10.1016/s0896-6273(01)00360-9subject
Has Abstractpub_date
2001-08-02 00:00:00pages
305-15issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(01)00360-9journal_volume
31pub_type
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