Abstract:
:The neocortex of mammals is composed of cortical fields that have a unique organization associated with the animal's ecological niche and lifestyle. Each cortical field has a specific pattern of connections with other cortical fields and brain structures, and together they comprise a neocortical network that generates a variety of behaviors. These networks and the behaviors they generate are variable across mammals, and are particularly complex in some species such as humans. Here I discuss the mechanisms that contribute to neocortical organization in mammals, and how this organization has been altered to generate the variability that exists in different lineages.
journal_name
Neuronjournal_title
Neuronauthors
Krubitzer Ldoi
10.1016/j.neuron.2007.10.002subject
Has Abstractpub_date
2007-10-25 00:00:00pages
201-8issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(07)00757-Xjournal_volume
56pub_type
杂志文章,评审相关文献
NEURON文献大全abstract::Action potentials initiate in the axon initial segment (AIS), a specialized compartment enriched with Na(+) and K(+) channels. Recently, we found that T- and R-type Ca(2+) channels are concentrated in the AIS, where they contribute to local subthreshold membrane depolarization and thereby influence action potential in...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.09.026
更新日期:2010-11-04 00:00:00
abstract::Neural circadian pacemakers can be reset by light, and the resetting mechanism may involve cyclic nucleotide second messengers. We have examined pacemaker resetting and free-running activity rhythms in Drosophila dunce (dnc) and DC0 mutants, which identify a cAMP specific phosphodiesterase and the catalytic subunit of...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90262-3
更新日期:1994-10-01 00:00:00
abstract::Many animals guide their movements using optic flow, the displacement of stationary objects across the retina caused by self-motion. How do animals selectively synthesize a global motion pattern from its local motion components? To what extent does this feature selectivity rely on circuit mechanisms versus dendritic p...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.08.022
更新日期:2018-10-10 00:00:00
abstract::In this issue of Neuron, Orbán et al. (2016) test whether the brain represents probabilities by sampling: do neurons interpret the world by generating causal explanations of sense data and quickly sample different interpretations over time? Orbán et al. (2016) find agreement between this model's predictions and neural...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.10.007
更新日期:2016-10-19 00:00:00
abstract::Understanding the neural basis of adaptation (repetition suppression) is critical for interpreting fMRI-adaptation experiments. Sawamura and colleagues provide a critical stepping-stone by elucidating the relation between neural adaptation and response selectivity. They find some cross-adaptation by two different stim...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2006.01.004
更新日期:2006-01-19 00:00:00
abstract::We review the central tenets and neuroanatomical basis of the global neuronal workspace (GNW) hypothesis, which attempts to account for the main scientific observations regarding the elementary mechanisms of conscious processing in the human brain. The GNW hypothesis proposes that, in the conscious state, a non-linear...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2020.01.026
更新日期:2020-03-04 00:00:00
abstract::Depending on the arousal state, neuronal networks display discrete activity patterns that profoundly affect information processing in the brain. In this issue of Neuron, Kurotani et al. report bidirectional modification of inhibition by oscillatory patterns in the neocortex; a mechanism likely to control the impact of...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2008.03.010
更新日期:2008-03-27 00:00:00
abstract::In this issue of Neuron, Crerar et al. (2019) found Tp53inp2 as a highly expressed RNA in sympathetic neuron axons. Strikingly, its long 3' UTR ensures that Tp53inp2 is not translated in axons, and the untranslated RNA affects neuronal growth by interacting with neurotrophin receptors. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.04.019
更新日期:2019-05-08 00:00:00
abstract::Neuronal responses of sensory cortex are highly variable, and this variability is correlated across neurons. To assess how variability reflects factors shared across a neuronal population, we analyzed the activity of many simultaneously recorded neurons in visual cortex. We developed a simple model that comprises two ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.06.035
更新日期:2015-08-05 00:00:00
abstract::Fear is a graded central motive state ranging from mild to intense. As threat intensity increases, fear transitions from discriminative to generalized. The circuit mechanisms that process threats of different intensity are not well resolved. Here, we isolate a unique population of locally projecting neurons in the cen...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.11.034
更新日期:2017-01-04 00:00:00
abstract::The parietal lobes of nonhuman primates have been well characterized by single neuron recordings, yet clear partitioning of the human parietal lobes has not been clearly demonstrated. An elegant new fMRI study by Simon and colleagues (this issue of Neuron) suggests that parietal cortex does indeed contain dissociable ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/s0896-6273(02)00584-6
更新日期:2002-01-31 00:00:00
abstract::The replay of previously stored memories during hippocampal sharp wave ripples (SWRs) is thought to support both memory retrieval and consolidation in distributed hippocampal-neocortical circuits. Replay events consist of precisely timed sequences of spikes from CA3 and CA1 neurons that are coordinated both within and...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.06.014
更新日期:2012-08-23 00:00:00
abstract::The visual perception of words is known to activate the auditory representation of their spoken forms automatically. We examined the neural mechanism for this phonological activation using transcranial magnetic stimulation (TMS) with a masked priming paradigm. The stimulation sites (left superior temporal gyrus [L-STG...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.09.030
更新日期:2006-11-09 00:00:00
abstract::Memory abilities differ greatly across individuals. To explore a source of these differences, we characterized the varied strategies people adopt during unconstrained encoding. Participants intentionally encoded object pairs during functional MRI. Principal components analysis applied to a strategy questionnaire revea...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.06.006
更新日期:2006-07-20 00:00:00
abstract:VIDEO ABSTRACT:Why do people often choose to cooperate when they can better serve their interests by acting selfishly? One potential mechanism is that the anticipation of guilt can motivate cooperative behavior. We utilize a formal model of this process in conjunction with fMRI to identify brain regions that mediate co...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.02.056
更新日期:2011-05-12 00:00:00
abstract::The ability of vertebrates to detect and avoid damaging extremes of temperature depends on activation of ion channels belonging to the thermo-TRP family. Injury or inflammation causes the release of inflammatory mediators which lower the threshold for detection of painful levels of heat, a process known as heat hypera...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.05.015
更新日期:2008-08-14 00:00:00
abstract::The Mg2+ block of NMDA-type glutamate receptors (NMDARs) is crucial to their function as synaptic coincidence detectors. An analysis of Drosophila expressing a Mg2+-independent NMDAR by in this issue of Neuron concludes that the Mg2+ block is required primarily for long-term memory. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2012.05.008
更新日期:2012-06-07 00:00:00
abstract::The signaling mechanisms that control the survival of CNS neurons are poorly understood. Here we show that, in contrast to PNS neurons, the survival of purified postnatal rat retinal ganglion cells (RGCs) in vitro is not promoted by peptide trophic factors unless their intracellular cAMP is increased pharmacologically...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90172-8
更新日期:1995-10-01 00:00:00
abstract::Local neuronal networks that are responsible for walking are poorly characterized in mammals. Using an innovative approach to identify interneuron inputs onto motorneuron populations in a neonatal rodent spinal cord preparation, we have investigated the network responsible for left-right coordination of the hindlimbs....
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00353-2
更新日期:2003-06-19 00:00:00
abstract::Persistent neural activity that outlasts an initial stimulus is thought to provide a mechanism for the transient storage of memory. In this issue of Neuron, Fransén et al. identify important principles for a cell-autonomous mechanism of graded persistent firing using an elegant combination of experimental and computat...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2006.02.010
更新日期:2006-03-02 00:00:00
abstract::The process by which neural circuitry in the brain plans and executes movements is not well understood. Until recently, most available data were limited either to single-neuron electrophysiological recordings or to measures of aggregate field or metabolism. Neither approach reveals how individual neurons' activities a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.05.047
更新日期:2011-08-11 00:00:00
abstract::Injured peripheral neurons successfully activate a proregenerative transcriptional program to enable axon regeneration and functional recovery. How transcriptional regulators coordinate the expression of such program remains unclear. Here we show that hypoxia-inducible factor 1α (HIF-1α) controls multiple injury-induc...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.09.050
更新日期:2015-11-18 00:00:00
abstract::The visual cortex represents stimuli through the activity of neuronal populations. We measured the evolution of this activity in space and time by imaging voltage-sensitive dyes in cat area V1. Contrast-reversing stimuli elicit responses that oscillate at twice the stimulus frequency, indicating that signals originate...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.06.017
更新日期:2007-07-05 00:00:00
abstract::During synaptic development, proteins aggregate at specialized pre- and postsynaptic structures. Mechanisms that mediate protein clustering at these sites remain unknown. To investigate this process, we analyzed synaptic targeting of a postsynaptic density protein, PSD-95, by expressing green fluorescent protein- (GFP...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80705-9
更新日期:1999-03-01 00:00:00
abstract::In this issue of Neuron, Tufail et al. present an underlying mechanism for microglia-mediated elimination of virally transduced cells in the central nervous system. These findings could contribute to the development of improved gene therapies for various neurological disorders by exploring why microglia destroy viable...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.01.025
更新日期:2017-02-08 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the P362L mutation in the low-complexity domain (LCD) of T cell-rest...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.07.025
更新日期:2017-08-16 00:00:00
abstract::The formation, function, and plasticity of synapses require dynamic changes in synaptic receptor composition. Here, we identify the sorting receptor SorCS1 as a key regulator of synaptic receptor trafficking. Four independent proteomic analyses identify the synaptic adhesion molecule neurexin and the AMPA glutamate re...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.08.007
更新日期:2015-08-19 00:00:00
abstract::Recent advances in connectomics have led to a synthesis of perspectives regarding the brain's functional organization that reconciles classical concepts of localized specialization with an appreciation for properties that emerge from interactions across distributed functional networks. This provides a more comprehensi...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2016.07.031
更新日期:2016-08-03 00:00:00
abstract::Expression of rat TrkA in Xenopus spinal neurons confers responsiveness of these neurons to nerve growth factor (NGF) in assays of neuronal survival and growth cone chemotropism. Mutational analysis indicates that coactivation of phospholipase C-gamma (PLC-gamma) and phosphoinositide 3-kinase (PI3-kinase) by specific ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80760-6
更新日期:1999-05-01 00:00:00
abstract::Microtubules play an important role in neuronal polarity. In this issue of Neuron, Watabe-Uchida et al. link a novel Rac-mediated pathway that regulates microtubule dynamics to axon formation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2006.08.020
更新日期:2006-09-21 00:00:00