Abstract：
:Vertebrate rod and cone photoreceptors hyperpolarize when illuminated. However, synaptic input from horizontal cells can depolarize cones and even elicit action potentials. Using the whole-cell tight-seal recording technique, we determined that, in solitary cones isolated from a lizard retina, action potentials can be generated by depolarizing current steps under conditions where only two ionic currents are activated. A dihydropyridine-sensitive, inward Ca2+ current that activates at potentials positive to -40 mV can regeneratively depolarize the cell. Subsequently, a SITS-sensitive, Ca2(+)-dependent outward Cl- current repolarizes the cell. We suggest that these ionic currents may help explain lateral inhibition in the retina.
journal_name
Neuronjournal_title
Neuronauthors
Maricq AV,Korenbrot JIdoi
10.1016/0896-6273(88)90181-xsubject
Has Abstractpub_date
1988-08-01 00:00:00pages
503-15issue
6eissn
0896-6273issn
1097-4199pii
0896-6273(88)90181-Xjournal_volume
1pub_type
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