Abstract：
:How do neurons develop, control, and maintain their electrical signaling properties in spite of ongoing protein turnover and perturbations to activity? From generic assumptions about the molecular biology underlying channel expression, we derive a simple model and show how it encodes an "activity set point" in single neurons. The model generates diverse self-regulating cell types and relates correlations in conductance expression observed in vivo to underlying channel expression rates. Synaptic as well as intrinsic conductances can be regulated to make a self-assembling central pattern generator network; thus, network-level homeostasis can emerge from cell-autonomous regulation rules. Finally, we demonstrate that the outcome of homeostatic regulation depends on the complement of ion channels expressed in cells: in some cases, loss of specific ion channels can be compensated; in others, the homeostatic mechanism itself causes pathological loss of function.
journal_name
Neuronjournal_title
Neuronauthors
O'Leary T,Williams AH,Franci A,Marder Edoi
10.1016/j.neuron.2014.04.002subject
Has Abstractpub_date
2014-05-21 00:00:00pages
809-21issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(14)00292-Xjournal_volume
82pub_type
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