Abstract:
:The ERK MAP kinase signaling cascade plays critical roles in brain development, learning, memory, and cognition. It has recently been appreciated that mutation or deletion of elements within this signaling pathway leads to developmental syndromes in humans that are associated with impaired cognitive function and autism. Here, we review recent studies that provide insight into the biological roles of the ERKs in the brain that may underlie the cognitive deficits seen in these syndromes.
journal_name
Neuronjournal_title
Neuronauthors
Samuels IS,Saitta SC,Landreth GEdoi
10.1016/j.neuron.2009.01.001subject
Has Abstractpub_date
2009-01-29 00:00:00pages
160-7issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(09)00041-5journal_volume
61pub_type
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