Abstract:
:Small G proteins are an extensive family of proteins that bind and hydrolyze GTP. They are ubiquitous inside cells, regulating a wide range of cellular processes. Recently, many studies have examined the role of small G proteins, particularly the Ras family of G proteins, in memory formation. Once thought to be primarily involved in the transduction of a variety of extracellular signals during development, it is now clear that Ras family proteins also play critical roles in molecular processing underlying neuronal and behavioral plasticity. We here review a number of recent studies that explore how the signaling of Ras family proteins contributes to memory formation. Understanding these signaling processes is of fundamental importance both from a basic scientific perspective, with the goal of providing mechanistic insights into a critical aspect of cognitive behavior, and from a clinical perspective, with the goal of providing effective therapies for a range of disorders involving cognitive impairments.
journal_name
Neuronjournal_title
Neuronauthors
Ye X,Carew TJdoi
10.1016/j.neuron.2010.09.013subject
Has Abstractpub_date
2010-11-04 00:00:00pages
340-61issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(10)00755-5journal_volume
68pub_type
杂志文章,评审相关文献
NEURON文献大全abstract::Acetylcholinesterase (AChE) density at the neuromuscular junction of frog cutaneous pectoris muscle was determined by electron microscope autoradiography and biochemistry to be approximately 600 sites micron-2 of postsynaptic area, approximately 4-fold lower than all previous reports (mouse), whereas the hydrolytic tu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90331-x
更新日期:1994-04-01 00:00:00
abstract::RNA transport is an important and fundamental event for local protein synthesis, especially in neurons. RNA is transported as large granules, but little is known about them. Here, we isolated a large RNase-sensitive granule (size: 1000S approximately) as a binding partner of conventional kinesin (KIF5). We identified ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.07.022
更新日期:2004-08-19 00:00:00
abstract::Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00008-8
更新日期:2000-07-01 00:00:00
abstract::What underlies the large variation in mEPSC amplitude in the auditory system? And is this variability important? In this issue of Neuron, Li et al. (2014) address the significance of large mEPSCs to auditory processing and Chapochnikov et al. (2014) describe a novel mechanism underlying them. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.09.013
更新日期:2014-09-17 00:00:00
abstract::Interneurons in the ventral spinal cord are essential for coordinated locomotion in vertebrates. During embryogenesis, the V0 and V1 classes of ventral interneurons are defined by expression of the homeodomain transcription factors Evx1/2 and En1, respectively. In this study, we show that Evx1 V0 interneurons are loca...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00213-6
更新日期:2001-02-01 00:00:00
abstract::Using somatic cell nuclear transfer, Hazen et al. (2016) examined clonally expanded single neurons for mutations and found ∼100 mutations from a variety of classes. Post-mitotic mutations in individual neurons represent an exploratory direction for finding fundamental origins of neurodegeneration. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2016.02.042
更新日期:2016-03-16 00:00:00
abstract::Fragile X-associated tremor/ataxia syndrome (FXTAS) is a recently described neurodegenerative disorder of older adult carriers of premutation alleles (60-200 CGG repeats) in the fragile X mental retardation gene (FMR1). It has been proposed that FXTAS is an RNA-mediated neurodegenerative disease caused by the titratio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.07.021
更新日期:2007-08-16 00:00:00
abstract::A new study by Yao et al. in the current issue of Cell proposes that a novel vesicular protein, dubbed Flower, regulates endocytosis by controlling presynaptic Ca(2+) levels. This finding is intriguing not only for its implications for vesicle cycling, but also for the multitude of Ca(2+)-dependent processes at play i...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.08.031
更新日期:2009-09-10 00:00:00
abstract::When speaking, we dynamically coordinate movements of our jaw, tongue, lips, and larynx. To investigate the neural mechanisms underlying articulation, we used direct cortical recordings from human sensorimotor cortex while participants spoke natural sentences that included sounds spanning the entire English phonetic i...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.04.031
更新日期:2018-06-06 00:00:00
abstract::A fundamental property of neuronal circuits is the ability to adapt to altered sensory inputs. It is well established that the functional synaptic changes underlying this adaptation are reflected by structural modifications in excitatory neurons. In contrast, the degree to which structural plasticity in inhibitory neu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.06.034
更新日期:2011-09-08 00:00:00
abstract::Two properties were found to distinguish neuronal from muscle nicotinic acetylcholine receptors (nAChRs). First, neuronal nAChRs have a greater Ca2+ permeability. The high Ca2+ flux through neuronal nAChRs activates a Ca(2+)-dependent Cl- conductance, and the Ca2+ to Cs+ permeability ratio (PCa/PCs) is 7 times greater...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90114-s
更新日期:1992-01-01 00:00:00
abstract::During normal vision, the focus of gaze continually jumps from one important image feature to the next. In this issue of Neuron, Mazer and Gallant analyze neural activity in higher-level visual cortex during this kind of active visual exploration, and they demonstrate a localized enhancement of visual responses that p...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00805-5
更新日期:2003-12-18 00:00:00
abstract::Presynaptic CaV2 channels are essential for Ca2+-triggered exocytosis. In addition, there are two competing models for their roles in synapse structure. First, Ca2+ channels or Ca2+ entry may control synapse assembly. Second, active zone proteins may scaffold CaV2s to presynaptic release sites, and synapse structure i...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.05.032
更新日期:2020-08-19 00:00:00
abstract::Neural representations of head direction (HD) have been discovered in many species. Theoretical work has proposed that the dynamics associated with these representations are generated, maintained, and updated by recurrent network structures called ring attractors. We evaluated this theorized structure-function relatio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.08.006
更新日期:2020-10-14 00:00:00
abstract::Promises are one of the oldest human-specific psychological mechanisms fostering cooperation and trust. Here, we study the neural underpinnings of promise keeping and promise breaking. Subjects first make a promise decision (promise stage), then they anticipate whether the promise affects the interaction partner's dec...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.11.017
更新日期:2009-12-10 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.02.008
更新日期:2008-04-24 00:00:00
abstract::Structure-function studies have identified key functional motifs in the acetylcholine receptor, including residues that contribute to the ion channel and to the ligand-binding sites. Little is known, however, about determinants of channel gating kinetics. To identify structural correlates of gating, we examined the st...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90424-3
更新日期:1994-12-01 00:00:00
abstract::The signaling mechanisms that control the survival of CNS neurons are poorly understood. Here we show that, in contrast to PNS neurons, the survival of purified postnatal rat retinal ganglion cells (RGCs) in vitro is not promoted by peptide trophic factors unless their intracellular cAMP is increased pharmacologically...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90172-8
更新日期:1995-10-01 00:00:00
abstract::In the CNS, activity of individual neurons has a small but quantifiable relationship to sensory representations and motor outputs. Coactivation of a few 10s to 100s of neurons can code sensory inputs and behavioral task performance within psychophysical limits. However, in a sea of sensory inputs and demand for comple...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2012.08.004
更新日期:2012-08-23 00:00:00
abstract::Using high resolution capacitance measurements, we have characterized an ultrafast component of transmitter release in ribbon-type synaptic terminals of retinal bipolar neurons. During depolarization, capacitance increases to a plateau of approximately 30 fF with a time constant of approximately 1.5 ms. When not limit...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80254-8
更新日期:1996-12-01 00:00:00
abstract::Commissural axons are attracted to the midline intermediate target by chemoattractants, but upon crossing the midline they switch off responsiveness to attractants and switch on responsiveness to midline repellents, which expel the axons from the midline and enable them to move on. Here we show that midline exit also ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.01.006
更新日期:2008-02-28 00:00:00
abstract::The function of the CB2 cannabinoid receptor in the brain has long been a matter of debate. In this issue of Neuron, Stempel et al. (2016) describe a mechanism whereby endocannabinoid production leads to a cell-intrinsic hyperpolarization that controls self activity. ...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2016.05.012
更新日期:2016-05-18 00:00:00
abstract::Primary nociceptors relay painful touch information from the periphery to the spinal cord. Although it is established that signals generated by receptor tyrosine kinases TrkA and Ret coordinate the development of distinct nociceptive circuits, mechanisms modulating TrkA or Ret pathways in developing nociceptors are un...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.04.009
更新日期:2014-05-07 00:00:00
abstract::When faced with a crowded visual scene, observers must selectively attend to behaviorally relevant objects to avoid sensory overload. Often this selection process is guided by prior knowledge of a target-defining feature (e.g., the color red when looking for an apple), which enhances the firing rate of visual neurons ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.06.015
更新日期:2007-07-19 00:00:00
abstract::Spinocerebellar ataxia type 1 (SCA1), due to the expansion of a polyglutamine repeat within the ubiquitously expressed Ataxin-1 protein, leads to the premature degeneration of Purkinje cells (PCs), the cause of which is poorly understood. Here, we identified the unique proteomic signature of Sca1(154Q/2Q) PCs at an ea...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.11.033
更新日期:2016-01-06 00:00:00
abstract::Recent progress in neurophysiological recording has developed in two directions. One relies on multimicroelectrodes to study correlations in neuron firing. The other relies on sophisticated tasks to distinguish successive stages of neuronal processing. In this issue of Neuron, Shichinohe et al. take this second approa...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2009.05.018
更新日期:2009-06-11 00:00:00
abstract::MicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs. The miRNA machinery interacts with fragile X mental retardation protein (FMRP), which functions as translational repressor. We show that miR-125b and miR-132, as well as several other miRNAs, are associated with FMRP in mouse brain. miR...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.01.005
更新日期:2010-02-11 00:00:00
abstract::We have used immunogold electron microscopy to study the organization of the acetylcholine receptor, 43 kd protein, voltage-sensitive Na+ channel, and ankyrin in the postsynaptic membrane of the rat neuromuscular junction. The acetylcholine receptor and the 43 kd protein are concentrated at the crests of the postsynap...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90029-9
更新日期:1989-08-01 00:00:00
abstract::Bcl-2 is a major regulator of programmed cell death, a critical process in shaping the developing nervous system. To assess whether Bcl-2 is involved in regulating neuronal survival and in mediating the neuroprotective action of neurotrophic factors, we generated Bcl-2-deficient mice. At birth, the number of facial mo...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80282-2
更新日期:1996-07-01 00:00:00
abstract::The present study utilized event-related fMRI to address the role of the human perirhinal cortex (PRC), and its interactions with the hippocampus, in memory consolidation. Participants encoded object-based and scene-based associations and then restudied them either after a "long" or "short" delay during which consolid...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.07.013
更新日期:2013-09-18 00:00:00