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Closed-loop and activity-guided optogenetic control.

Abstract：

:Advances in optical manipulation and observation of neural activity have set the stage for widespread implementation of closed-loop and activity-guided optical control of neural circuit dynamics. Closing the loop optogenetically (i.e., basing optogenetic stimulation on simultaneously observed dynamics in a principled way) is a powerful strategy for causal investigation of neural circuitry. In particular, observing and feeding back the effects of circuit interventions on physiologically relevant timescales is valuable for directly testing whether inferred models of dynamics, connectivity, and causation are accurate in vivo. Here we highlight technical and theoretical foundations as well as recent advances and opportunities in this area, and we review in detail the known caveats and limitations of optogenetic experimentation in the context of addressing these challenges with closed-loop optogenetic control in behaving animals.

journal_name

Neuron

journal_title

Neuron

authors

Grosenick L,Marshel JH,Deisseroth K

doi

10.1016/j.neuron.2015.03.034

subject

Has Abstract

pub_date

2015-04-08 00:00:00

pages

106-39

issue

1

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(15)00258-5

journal_volume

86

pub_type

杂志文章,评审

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