Abstract：
:AMPA-type glutamate receptors (AMPARs) are responsible for a variety of processes in the mammalian brain including fast excitatory neurotransmission, postsynaptic plasticity, or synapse development. Here, with comprehensive and quantitative proteomic analyses, we demonstrate that native AMPARs are macromolecular complexes with a large molecular diversity. This diversity results from coassembly of the known AMPAR subunits, pore-forming GluA and three types of auxiliary proteins, with 21 additional constituents, mostly secreted proteins or transmembrane proteins of different classes. Their integration at distinct abundance and stability establishes the heteromultimeric architecture of native AMPAR complexes: a defined core with a variable periphery resulting in an apparent molecular mass between 0.6 and 1 MDa. The additional constituents change the gating properties of AMPARs and provide links to the protein dynamics fundamental for the complex role of AMPARs in formation and operation of glutamatergic synapses.
journal_name
Neuronjournal_title
Neuronauthors
Schwenk J,Harmel N,Brechet A,Zolles G,Berkefeld H,Müller CS,Bildl W,Baehrens D,Hüber B,Kulik A,Klöcker N,Schulte U,Fakler Bdoi
10.1016/j.neuron.2012.03.034subject
Has Abstractpub_date
2012-05-24 00:00:00pages
621-33issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(12)00345-5journal_volume
74pub_type
杂志文章相关文献
NEURON文献大全abstract：:The precise subunit composition of synaptic ionotropic receptors in the brain is poorly understood. This information is of particular importance with regard to AMPA-type glutamate receptors, the multimeric complexes assembled from GluA1-A4 subunits, as the trafficking of these receptors into and out of synapses is pro...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.02.027
更新日期：2009-04-30 00:00:00
abstract：:Motor behaviors recruit task-specific neuronal ensembles in motor cortices, which are consolidated over subsequent learning. However, little is known about the molecules that can identify the participating neurons and predict the outcomes of the consolidation process. Using a mouse rotarod-learning task, we showed tha...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.05.022
更新日期：2015-06-17 00:00:00
abstract：:Recent neurophysiological studies reveal that neurons in certain brain structures carry specific signals about past and future rewards. Dopamine neurons display a short-latency, phasic reward signal indicating the difference between actual and predicted rewards. The signal is useful for enhancing neuronal processing a...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(02)00967-4
更新日期：2002-10-10 00:00:00
abstract：:Expression of aversive memories is key for survival, but the underlying brain mechanisms are not fully understood. Medial habenular (MHb) axons corelease glutamate and acetylcholine onto target postsynaptic interpeduncular (IPN) neurons, but their role in aversive memories has not been addressed so far. We found that ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.08.035
更新日期：2015-10-21 00:00:00
abstract：:Motor units comprise a pre-synaptic motor neuron and multiple post-synaptic muscle fibers. Many movement disorders disrupt motor unit contractile dynamics and the structure of sarcomeres, skeletal muscle's contractile units. Despite the motor unit's centrality to neuromuscular physiology, no extant technology can imag...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.11.022
更新日期：2015-12-16 00:00:00
abstract：:Recent studies suggest that increased activity of cyclin-dependent kinase 5 (Cdk5) may contribute to neuronal death and cytoskeletal abnormalities in Alzheimer's disease. We report here such deregulation of Cdk5 activity associated with the hyperphosphorylation of tau and neurofilament (NF) proteins in mice expressing...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00268-9
更新日期：2001-04-01 00:00:00
abstract：:The pathways that convert neural stem cells (NSCs) into functional neurons in the adult hippocampus are tightly regulated. In this issue of Neuron, Yeh et al. (2018) demonstrate that the activity of dentate mossy cells determines the balance between quiescence and activation of NSCs. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.07.044
更新日期：2018-08-08 00:00:00
abstract：:Microtubules play an important role in neuronal polarity. In this issue of Neuron, Watabe-Uchida et al. link a novel Rac-mediated pathway that regulates microtubule dynamics to axon formation. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2006.08.020
更新日期：2006-09-21 00:00:00
abstract：:The inner ear's performance is greatly enhanced by an active process defined by four features: amplification, frequency selectivity, compressive nonlinearity, and spontaneous otoacoustic emission. These characteristics emerge naturally if the mechanoelectrical transduction process operates near a dynamical instability...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2008.07.012
更新日期：2008-08-28 00:00:00
abstract：:Grid cells, border cells, head-directions cells, and conjunctive correlates found in the Medial Entorhinal Cortex (MEC) indicate the presence of highly specialized neural circuits that process allocentric space. New technical advancements, as described by Tang et al. (2014) in this issue, offer an integrated approach ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2014.12.013
更新日期：2014-12-17 00:00:00
abstract：:In the precedence effect, sounds emanating directly from the source are localized preferentially over their reflections. Although most studies have focused on the delay between the onset of a sound and its echo, humans still experience the precedence effect when this onset delay is removed. We tested in barn owls the ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.07.014
更新日期：2010-08-26 00:00:00
abstract：:We have studied the subcellular distribution of the alpha 1 and alpha 2 subunits of the dihydropyridine (DHP) receptor and ankyrin in rat skeletal muscle with immunofluorescence and immunogold labeling techniques. All three proteins were concentrated in the triad junction formed between the T-tubules and sarcoplasmic ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90170-k
更新日期：1990-09-01 00:00:00
abstract：:We recently reported that homozygous Presenilin-1 (Psen1) knockin (KI) mice carrying the familial Alzheimer's disease (FAD) mutation L435F or C410Y recapitulate the phenotypes of Psen1(-/-) mice. Production and steady-state levels of Aβ40 and Aβ42 are undetectable in KI/KI brains and reduced in KI/+ brains, though the...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2016.03.009
更新日期：2016-04-20 00:00:00
abstract：:Rho GTPases are essential regulators of cytoskeletal reorganization, but how they do so during neuronal morphogenesis in vivo is poorly understood. Here we show that the actin depolymerization factor cofilin is essential for axon growth in Drosophila neurons. Cofilin function in axon growth is inhibited by LIM kinase ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.11.014
更新日期：2004-12-02 00:00:00
abstract：:The combination of brain imaging and genetics promises to identify neural mechanisms underlying complex traits such as cognition and psychiatric disorder. The study by Heck et al. (2014) in this issue of Neuron highlights voltage-gated cation channel activity as a likely link and culprit. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2014.02.023
更新日期：2014-03-05 00:00:00
abstract：:Balance between excitation and inhibition (E-I balance) in neural circuits is believed to be tightly regulated. To the contrary, in this issue of Neuron, Bridi et al. (2020) reveal that inverse oscillations of synaptic inhibition and excitation lead to peaks and valleys in E-I balance across the 24 h day. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2020.01.035
更新日期：2020-02-19 00:00:00
abstract：:The identification of surface proteins restricted to subsets of embryonic axons and growth cones may provide information on the mechanisms underlying axon fasciculation and pathway selection in the vertebrate nervous system. We describe here the characterization of a 135 kd cell surface glycoprotein, TAG-1, that is ex...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(88)90194-8
更新日期：1988-04-01 00:00:00
abstract：:Among the diverse interneuron subtypes in the neocortex, chandelier cells (ChCs) are the only population that selectively innervate pyramidal neurons (PyNs) at their axon initial segment (AIS), the site of action potential initiation, allowing them to exert powerful control over PyN output. Yet, mechanisms underlying ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.02.009
更新日期：2019-04-17 00:00:00
abstract：:Effective mental functioning requires that cognition be protected from emotional conflict due to interference by task-irrelevant emotionally salient stimuli. The neural mechanisms by which the brain detects and resolves emotional conflict are still largely unknown, however. Drawing on the classic Stroop conflict task,...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.07.029
更新日期：2006-09-21 00:00:00
abstract：:Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and nociception are coded and discriminated. Here, we tested the multimodal capacity of peripheral first-order neurons, focusing on the genetically defined subpopu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.03.021
更新日期：2020-06-17 00:00:00
abstract：:Olfactory receptor neurons (ORNs) transform scant chemical inputs into significant neural signals. This transformation requires signal amplification. In this issue of Neuron, Ng et al. (2019) identified a mechanism by which the signals evoked by pheromones are amplified in the ORNs that selectively promote courtship b...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2019.11.021
更新日期：2019-12-04 00:00:00
abstract：:We have investigated the cell cycle-related mechanisms that lead to the emergence of primate areas 17 and 18. These areas are characterized by striking differences in cytoarchitectonics and neuron number. We show in vivo that (1) area 17 precursors of supragranular neurons exhibit a shorter cell cycle duration, a redu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.06.032
更新日期：2005-08-04 00:00:00
abstract：:Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFR alpha), suggesting that PDGF mediates a paracrine interaction between these cells. T...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80244-5
更新日期：1996-12-01 00:00:00
abstract：:In this issue of Neuron, Moehle et al. (2017) demonstrate that presynaptic muscarinic receptors counteract the effects of dopamine in an output nucleus of the basal ganglia. They provide intracellular, anatomical, and network-level mechanisms for this cholinergic-dopaminergic interplay. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2017.12.014
更新日期：2017-12-20 00:00:00
abstract：:In this issue of Neuron, Crerar et al. (2019) found Tp53inp2 as a highly expressed RNA in sympathetic neuron axons. Strikingly, its long 3' UTR ensures that Tp53inp2 is not translated in axons, and the untranslated RNA affects neuronal growth by interacting with neurotrophin receptors. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2019.04.019
更新日期：2019-05-08 00:00:00
abstract：:The link between dysregulated serotonergic activity and depression and anxiety disorders is well established, yet the molecular mechanisms underlying these psychopathologies are not fully understood. Here, we explore the role of microRNAs in regulating serotonergic (5HT) neuron activity. To this end, we determined the...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.05.042
更新日期：2014-07-16 00:00:00
abstract：:Mesolimbic dopamine (DA) neurons play a central role in motivation and reward processing. Although the activity of these mesolimbic DA neurons is controlled by afferent inputs, little is known about the circuits in which they are embedded. Using retrograde tracing, electrophysiology, optogenetics, and behavioral assay...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.12.022
更新日期：2018-01-17 00:00:00
abstract：:Ultra-slow, ∼0.1-Hz variations in the oxygenation level of brain blood are widely used as an fMRI-based surrogate of "resting-state" neuronal activity. The temporal correlations among these fluctuations across the brain are interpreted as "functional connections" for maps and neurological diagnostics. Ultra-slow varia...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2020.07.020
更新日期：2020-09-09 00:00:00
abstract：:Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron su...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.03.025
更新日期：2011-06-09 00:00:00
abstract：:A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.09.027
更新日期：2008-10-09 00:00:00
