Abstract:
:The mechanisms controlling the transition from neurogenesis to gliogenesis in the vertebrate CNS are incompletely understood. We identified a family of transcription factors, called NFI genes, which are induced throughout the spinal cord ventricular zone (VZ) concomitantly with the induction of GLAST, an early marker of gliogenesis. NFIA is both necessary and sufficient for GLAST induction in the VZ. Unexpectedly, NFIA is also essential for the continued inhibition of neurogenesis in VZ progenitors. This function is mediated by the requirement of NFIA for the expression of HES5, a Notch effector. However, Notch effectors are unable to promote glial-fate specification in the absence of NFIA. Thus, NFIA links the abrogation of neurogenesis to a generic program of gliogenesis, in both astrocyte and oligodendrocyte VZ progenitors. At later stages, NFIA promotes migration and differentiation of astrocyte precursors, a function that is antagonized in oligodendrocyte precursors by Olig2.
journal_name
Neuronjournal_title
Neuronauthors
Deneen B,Ho R,Lukaszewicz A,Hochstim CJ,Gronostajski RM,Anderson DJdoi
10.1016/j.neuron.2006.11.019subject
Has Abstractpub_date
2006-12-21 00:00:00pages
953-68issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(06)00914-7journal_volume
52pub_type
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