Robust microcircuit synchronization by inhibitory connections.

Abstract:

:Microcircuits in different brain areas share similar architectural and biophysical properties with compact motor networks known as central pattern generators (CPGs). Consequently, CPGs have been suggested as valuable biological models for understanding of microcircuit dynamics and particularly, their synchronization. We use a well known compact motor network, the lobster pyloric CPG to study principles of intercircuit synchronization. We couple separate pyloric circuits obtained from two animals via artificial synapses and observe how their synchronization depends on the topology and kinetic parameters of the computer-generated synapses. Stable in-phase synchronization appears when electrically coupling the pacemaker groups of the two networks, but reciprocal inhibitory connections produce more robust and regular cooperative activity. Contralateral inhibitory connections offer effective synchronization and flexible setting of the burst phases of the interacting networks. We also show that a conductance-based mathematical model of the coupled circuits correctly reproduces the observed dynamics illustrating the generality of the phenomena.

journal_name

Neuron

journal_title

Neuron

authors

Szücs A,Huerta R,Rabinovich MI,Selverston AI

doi

10.1016/j.neuron.2008.12.032

subject

Has Abstract

pub_date

2009-02-12 00:00:00

pages

439-53

issue

3

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(09)00038-5

journal_volume

61

pub_type

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