Abstract:
:The chain length and end groups of linear PEG grafted on smooth surfaces is known to influence protein adsorption and thrombocyte adhesion. Here, it is explored whether established structure function relationships can be transferred to application relevant, rough surfaces. Functionalization of poly(ether imide) (PEI) membranes by grafting with monoamino PEG of different chain lengths (Mn =1 kDa or 10 kDa) and end groups (methoxy or hydroxyl) is proven by spectroscopy, changes of surface hydrophilicity, and surface shielding effects. The surface functionalization does lead to reduction of adsorption of BSA, but not of fibrinogen. The thrombocyte adhesion is increased compared to untreated PEI surfaces. Conclusively, rough instead of smooth polymer or gold surfaces should be investigated as relevant models.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Neffe AT,von Ruesten-Lange M,Braune S,Luetzow K,Roch T,Richau K,Jung F,Lendlein Adoi
10.1002/mabi.201300309subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1720-9issue
12eissn
1616-5187issn
1616-5195journal_volume
13pub_type
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