Design of a Bioabsorbable Multilayered Patch for Esophagus Tissue Engineering.


:A gold standard for esophagus reconstruction is not still available. The present work aims to design a polymer patch combining synthetic polylactide-co-polycaprolacton and chitosan biopolymers, tailoring patch properties to esophageal tissue characteristics by a temperature-induced precipitation method, to get multilayered patches (1L, 2L, and 3L). Characterization shows stable multilayered patches (1L and 2L) by selection of copolymer type, and their M w . In vitro investigation of the functional patch properties in simulated physiologic and pathologic conditions demonstrates that the chitosan layer (patch 3L) decreases patch stability and cell adhesion, while improves cell proliferation. Patches 2L and 3L comply with physiological esophageal pressure (3-5 kPa) and elongation (20%).


Macromol Biosci


Dorati R,De Trizio A,Marconi S,Ferrara A,Auricchio F,Genta I,Modena T,Benazzo M,Benazzo A,Volpato G,Conti B




Has Abstract


2017-06-01 00:00:00










  • A microfluidic approach to encapsulate living cells in uniform alginate hydrogel microparticles.

    abstract::A microfluidic technique is described to encapsulate living cells in alginate hydrogel microparticles generated from monodisperse double-emulsion templates. A microcapillary device is used to fabricate double emulsion templates composed of an alginate drop surrounded by a mineral oil shell. Hydrogel formation begins w...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Martinez CJ,Kim JW,Ye C,Ortiz I,Rowat AC,Marquez M,Weitz D

    更新日期:2012-07-01 00:00:00

  • Thermosensitive "Smart" Surfaces for Biorecognition Based Cell Adhesion and Controlled Detachment.

    abstract::The biorecognition-based control of attachment/detachment of MCF-7 cancer cells from polymer-coated surfaces is demonstrated. A glass surface is coated with a thermoresponsive statistical copolymer of poly(N-isopropylacrylamide-co-acrylamide) [p(NIPAm-co-Am)], which is end-capped with the Gly-Arg-Gly-Asp-Ser (GRGDS) p...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Brunato S,Mastrotto F,Bellato F,Garofalo M,Göddenhenrich T,Mantovani G,Alexander C,Gross S,Salmaso S,Caliceti P

    更新日期:2020-11-04 00:00:00

  • Efficient encapsulation of plasmid DNA in pH-sensitive PMPC-PDPA polymersomes: study of the effect of PDPA block length on copolymer-DNA binding affinity.

    abstract::We report the self-assembly of a series of amphiphilic diblock copolymers comprising a biocompatible, hydrophilic block, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) and a pH-sensitive block, poly(2-(diisopropylamino)ethyl methacrylate) (PDPA), into a dispersion of colloidally stable, nanometer-sized polymers...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Lomas H,Du J,Canton I,Madsen J,Warren N,Armes SP,Lewis AL,Battaglia G

    更新日期:2010-05-14 00:00:00

  • Biological natural retting for determining the hierarchical structuration of banana fibers.

    abstract::Extraction processes of natural fibers can be performed by different procedures that include mechanical, chemical and biological methods. Each method presents different advantages or drawbacks according to the amount of fiber produced or the quality and properties of fiber bundles obtained. In this study, biological n...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Gañán P,Zuluaga R,Velez JM,Mondragon I

    更新日期:2004-10-20 00:00:00

  • Triggered drug release from dynamic microspheres via a protein conformational change.

    abstract::In this study we formed and characterized dynamic hydrogel microspheres in which a protein conformational change was used to control microsphere volume changes and the release of an encapsulated drug. In particular, a specific biochemical ligand, trifluoperazine, induced calmodulin's nanometer scale conformation chang...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: King WJ,Pytel NJ,Ng K,Murphy WL

    更新日期:2010-06-11 00:00:00

  • A New Antimicrobial Agent: Poly (3-hydroxybutyric acid) Oligomer.

    abstract::In this work, it is first reported that the poly (3-hydroxybutyric acid) (PHB) oligomer with a few degrees of polymerization possesses effective antibacterial and antifungal properties. Two preparation methods for the PHB oligomer are described, namely, one-step ring-opening polymerization of β-butyrolactone and extra...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Ma L,Zhang Z,Li J,Yang X,Fei B,Leung PHM,Tao X

    更新日期:2019-05-01 00:00:00

  • Poly(polyol sebacate) Elastomers as Coatings for Metallic Coronary Stents.

    abstract::Biocompatible polymeric coatings for metallic stents are desired, as currently used materials present limitations such as deformation during degradation and exponential loss of mechanical properties after implantation. These concerns, together with the present risks of the drug-eluting stents, namely, thrombosis and r...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Navarro L,Mogosanu DE,de Jong T,Bakker AD,Schaubroeck D,Luna J,Rintoul I,Vanfleteren J,Dubruel P

    更新日期:2016-11-01 00:00:00

  • Recent Strategies in Tissue Engineering for Guided Peripheral Nerve Regeneration.

    abstract::The repair of large crushed or sectioned segments of peripheral nerves remains a challenge in regenerative medicine due to the complexity of the biological environment and the lack of proper biomaterials and architecture to foster reconstruction. Traditionally such reconstruction is only achieved by using fresh human ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审


    authors: Belanger K,Dinis TM,Taourirt S,Vidal G,Kaplan DL,Egles C

    更新日期:2016-04-01 00:00:00

  • Innovative Methods and Applications in Mucoadhesion Research.

    abstract::The present review is aimed at elucidating relatively new aspects of mucoadhesion/mucus interaction and related phenomena that emerged from a Mucoadhesion workshop held in Munster on 2-3 September 2015 as a satellite event of the ICCC 13th-EUCHIS 12th. After a brief outline of the new issues, the focus is on mucus des...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审


    authors: Mackie AR,Goycoolea FM,Menchicchi B,Caramella CM,Saporito F,Lee S,Stephansen K,Chronakis IS,Hiorth M,Adamczak M,Waldner M,Nielsen HM,Marcelloni L

    更新日期:2017-08-01 00:00:00

  • Crosslinking of trimethylene carbonate and D, L-lactide (co-) polymers by gamma irradiation in the presence of pentaerythritol triacrylate.

    abstract::High-molecular-weight (co)polymers of trimethylene carbonate and D,L-lactide are efficiently crosslinked using PETA during gamma irradiation. Form-stable networks with gel contents of 86 ± 5 to 96 ± 1 are obtained from non-crystalline (co)polymers. Glass transition temperatures and elastic moduli of the networks can b...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Bat E,van Kooten TG,Feijen J,Grijpma DW

    更新日期:2011-07-07 00:00:00

  • Novel photopolymerizable biodegradable triblock polymers for tissue engineering scaffolds: synthesis and characterization.

    abstract::For use in micro-patterned scaffolds in tissue engineering, novel diacrylated triblock macromers (PLA-b-PCL-b-PLA, PGA-b-PCL-b-PGA and PCL-b-PEO-b-PCL) were synthesized and characterized by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (NMR) and gel permeation chromatography (...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Chan-Park MB,Zhu AP,Shen JY,Fan AL

    更新日期:2004-07-14 00:00:00

  • New insight into biodegradation of polylactide (PLA)/clay nanocomposites using molecular ecological techniques.

    abstract::Novel molecular ecological techniques were used to study changes in microbial community structure and population during degradation of polylactide (PLA)/organically modified layered silicates (OMLS) nanocomposites. Cloned gene sequences belonging to members of the phyla Actinobacteria and Ascomycota comprized the most...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Sangwan P,Way C,Wu DY

    更新日期:2009-07-07 00:00:00

  • Tissue engineering polymeric microcarriers with macroporous morphology and bone-bioactive surface.

    abstract::PCL microspheres featuring a macroporous morphology and a bone-bioactive surface have been prepared. 'Camphene' was introduced to generate pores within the microsphere network. The pore size was variable from a few to tens to hundreds of microm depending on the Camphene/PCL ratio. Macropores (with sizes >50 microm) co...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Hong SJ,Yu HS,Kim HW

    更新日期:2009-07-07 00:00:00

  • Washless Method Enables Multilayer Coating of an Aggregation-Prone Nanoparticulate Drug Delivery System with Enhanced Yields, Colloidal Stability, and Scalability.

    abstract::Aggregation is frequently encountered during coating nanoparticles, especially when the core is not solid and the coating polyelectrolytes are weak. Here, the coating of a nanoliposome with two weak polyelectrolytes, alginate and chitosan, is investigated. First, quartz crystal microbalance with dissipation, atomic fo...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Nayef L,Castiello R,Tabrizian M

    更新日期:2017-06-01 00:00:00

  • Three-Layered Biodegradable Micelles Prepared by Two-Step Self-Assembly of PLA-PEI-PLA and PLA-PEG-PLA Triblock Copolymers as Efficient Gene Delivery System.

    abstract::"Three-layered micelles" (3LM) composed of two triblock copolymers, poly(L-lactide)-b-polyethyleneimine-b-poly(L-lactide) (PLLA-PEI-PLLA) and poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) (PLLA-PEG-PLLA) are designed to combine electrostatic interaction and solvent-induced condensation of DNA. The low mole...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Abebe DG,Kandil R,Kraus T,Elsayed M,Merkel OM,Fujiwara T

    更新日期:2015-05-01 00:00:00

  • A new approach for in vitro imaging of breast cancer cells by anti-metadherin targeted PVA-pyrene.

    abstract::Poly(vinyl alcohol)-pyrene-anti-metadherin (PVA-Py-(Anti-MTDH)), a novel antibody based water soluble probe containing both fluorescent and target sites in the structure for in vitro imaging of breast cancer cells is reported here. Since breast cancer cells have an excess of MDTH protein expressed on the surface, a PV...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Medine EI,Odaci D,Gacal BN,Gacal B,Sakarya S,Unak P,Timur S,Yagci Y

    更新日期:2010-06-11 00:00:00

  • Stabilization of gelatin nanoparticles without crosslinking.

    abstract::Gelatin nanoparticles can be stabilized by entrapping them in Eudragit E100 nanospheres. The size of the nanospheres was dependent on the homogenization speed, producing nanospheres of 433 nm (8000 rpm) and 176 nm (15000 rpm). The nanoparticle morphology was critically dependent on Eudragit E100 concentration; with 2%...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Khan SA,Schneider M

    更新日期:2014-11-01 00:00:00

  • Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils.

    abstract::Tissue damage caused by excessive amounts of neutrophil-derived reactive oxygen species (ROS) occurs in many inflammatory diseases. Butyrate is a short-chain fatty acid (SCFA) with known anti-inflammatory properties, able to modulate several neutrophil functions. Evidence is provided here that butyrate inhibits neutro...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Sacco P,Decleva E,Tentor F,Menegazzi R,Borgogna M,Paoletti S,Kristiansen KA,Vårum KM,Marsich E

    更新日期:2017-11-01 00:00:00

  • Calcium Signaling Regulates Valvular Interstitial Cell Alignment and Myofibroblast Activation in Fast-Relaxing Boronate Hydrogels.

    abstract::The role viscoelasticity in fibrotic disease progression is an emerging area of interest. Here, a fast-relaxing hydrogel system is exploited to investigate potential crosstalk between calcium signaling and mechanotransduction. Poly(ethylene glycol) (PEG) hydrogels containing boronate and triazole crosslinkers are synt...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Ma H,Macdougall LJ,GonzalezRodriguez A,Schroeder ME,Batan D,Weiss RM,Anseth KS

    更新日期:2020-12-01 00:00:00

  • Micro-engineered 3D scaffolds for cell culture studies.

    abstract::Cells in physiological 3D environments differ considerably in morphology and differentiation from those in 2D tissue culture. Naturally derived polymer systems are frequently used to study cells in 3D. These 3D matrices are complex with respect to their chemical composition, mechanical properties, and geometry. Theref...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审


    authors: Greiner AM,Richter B,Bastmeyer M

    更新日期:2012-10-01 00:00:00

  • Effect of Terminal Modification on the Molecular Assembly and Mechanical Properties of Protein-Based Block Copolymers.

    abstract::Accurate prediction and validation of the assembly of bioinspired peptide sequences into fibers with defined mechanical characteristics would aid significantly in designing and creating materials with desired properties. This process may also be utilized to provide insight into how the molecular architecture of many n...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Jacobsen MM,Tokareva OS,Ebrahimi D,Huang W,Ling S,Dinjaski N,Li D,Simon M,Staii C,Buehler MJ,Kaplan DL,Wong JY

    更新日期:2017-09-01 00:00:00

  • Synthesis and chemical recycling of novel poly(ester-urethane)s using an enzyme.

    abstract::A series of enzymatically recyclable poly(ester-urethane)s consisting of a biodegradable diurethane moiety as a hard segment and an ester moiety as an enzymatically cleavable linkage was chemo-enzymatically prepared by two routes. The poly(ester-urethane) was prepared by a) the ring-opening polymerization of a cyclic ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Soeda Y,Toshima K,Matsumura S

    更新日期:2005-04-19 00:00:00

  • Polysaccharides and their derivatives for versatile tissue engineering application.

    abstract::Research and development in the design, synthesis, modification, evaluation, and characterization of polysaccharide-based bioactive polymeric materials for guiding and promoting new tissue in-growth is reviewed. Emphasis is given in this interdisciplinary field of tissue engineering (TE) with particular reference to b...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审


    authors: Khan F,Ahmad SR

    更新日期:2013-04-01 00:00:00

  • Stereoblock poly(lactic acid): synthesis via solid-state polycondensation of a stereocomplexed mixture of poly(L-lactic acid) and poly(D-lactic acid).

    abstract::Stereoblock poly(lactic acid) consisting of D- and L-lactate stereosequences can be successfully synthesized by solid-state polycondensation of a 1:1 mixture of poly(L-lactic acid) and poly(D-lactic acid). In the first step, melt-polycondensation of L- and D-lactic acids is conducted to synthesize poly(L-lactic acid) ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Fukushima K,Furuhashi Y,Sogo K,Miura S,Kimura Y

    更新日期:2005-01-14 00:00:00

  • Sweet Vector for Gene Delivery: the Sugar Decoration of Polyplexes Reduces Cytotoxicity with a Balanced Effect on Gene Expression.

    abstract::The use of sugar-functionalized polyplexes as a nonviral gene delivery vector with lower cytotoxicity than the well-known polymeric carrier branched polyethyleneimine (BPEI) is investigated. The substitution of primary amine groups in the BPEI chains with lactose residues leads to larger polyplexes, presumably due to ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Albuquerque LJC,Alavarse AC,Carlan da Silva MC,Zilse MS,Barth MT,Bellettini IC,Giacomelli FC

    更新日期:2018-02-01 00:00:00

  • Immobilization of Enzymes on PLGA Sub-Micrometer Particles by Crosslinked Layer-by-Layer Deposition.

    abstract::Enzyme immobilization is of high interest for industrial applications. However, immobilization may compromise enzyme activity or stability due to the harsh conditions which have to be applied. The authors therefore present a new and improved crosslinked layer-by-layer (cLbL) approach. Two different model enzymes (acid...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Sieber S,Siegrist S,Schwarz S,Porta F,Schenk SH,Huwyler J

    更新日期:2017-08-01 00:00:00

  • Preparation of a novel polymer-modified si surface for DNA immobilization.

    abstract::The design of a novel polymer-modified overlayer composed of PPAPE and GPMS on a silicon wafer for immobilization of DNA molecules is described. After hydroxylation of Si(100) surfaces, GPMS molecules were self-assembled onto these surfaces. PPAPE molecules were then covalently attached to the epoxy-terminated surface...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Demirel GB,Coşkun S,Kalkan M,Caykara T

    更新日期:2009-05-13 00:00:00

  • In vivo Degradation and histocompatibility of a novel class of fluorescent copolyanhydrides, poly{[di(p-carboxyphenyl) succinate]-co-(sebacic anhydride)}.

    abstract::In this work, the in vivo degradation and tissue compatibility of a novel class of inherently fluorescent copolyanhydrides, P(dCPS:SA), were investigated. It was found that the degradation of the copolyanhydrides increased with the increase of SA content in the copolymers. The in vivo degradation rate of the copolymer...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Fan J,Li Y,Jiang H,Tang G,Wang L

    更新日期:2008-05-13 00:00:00

  • Nonionic Dendritic and Carbohydrate Based Amphiphiles: Self-Assembly and Transport Behavior.

    abstract::Herein, a new series of non-ionic dendritic and carbohydrate based amphiphiles is synthesized employing biocompatible starting materials and studied for supramolecular aggregate formation in aqueous solution. The dendritic amphiphiles 12 and 13 possessing poly(glycerol) [G2.0] as hydrophilic unit and C-10 and C-18 hyd...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Prasad S,Achazi K,Schade B,Haag R,Sharma SK

    更新日期:2018-07-01 00:00:00

  • Development of mucoadhesive drug delivery system using phenylboronic acid functionalized poly(D,L-lactide)-b-dextran nanoparticles.

    abstract::Mucoadhesive NP drug carriers have attracted substantial interest as a potential treatment for anterior eye diseases. NPs composed of PLA-Dex surface functionalized with a mucoadhesive ligand, PBA, were developed as drug carriers with particle sizes ranging from 25 to 28 nm. Using CycA as a model drug, we showed that ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Liu S,Jones L,Gu FX

    更新日期:2012-12-01 00:00:00