Tissue engineering polymeric microcarriers with macroporous morphology and bone-bioactive surface.

abstract：:Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro releas...

journal_title：Macromolecular bioscience

authors： Ouimet MA,Fogaça R,Snyder SS,Sathaye S,Catalani LH,Pochan DJ,Uhrich KE

更新日期：2015-03-01 00:00:00

abstract：:Tissue damage caused by excessive amounts of neutrophil-derived reactive oxygen species (ROS) occurs in many inflammatory diseases. Butyrate is a short-chain fatty acid (SCFA) with known anti-inflammatory properties, able to modulate several neutrophil functions. Evidence is provided here that butyrate inhibits neutro...

journal_title：Macromolecular bioscience

authors： Sacco P,Decleva E,Tentor F,Menegazzi R,Borgogna M,Paoletti S,Kristiansen KA,Vårum KM,Marsich E

更新日期：2017-11-01 00:00:00

abstract：:S-Layer proteins are an example of bionanostructures that can be exploited in nanofabrication. In addition to their ordered structure, the ability to self-assembly is a key feature that makes them a promising technological tool. Here, in vitro self-assembly kinetics of SpbA was investigated, and found that it occurs a...

journal_title：Macromolecular bioscience

authors： Teixeira LM,Strickland A,Mark SS,Bergkvist M,Sierra-Sastre Y,Batt CA

更新日期：2010-02-11 00:00:00

abstract：:Peptide dendrimers assembled by solid-phase peptide synthesis using a branching diamino acid at every 2(nd) or 3(rd) position provide readily accessible synthetic model systems for proteins and enzymes. They adopt a globular shape by topology rather than by folding. Peptide dendrimers of 2(nd) and 3(rd) generation fun...

journal_title：Macromolecular bioscience

authors： Delort E,Szöcs E,Widmer R,Siegenthaler H,Reymond JL

更新日期：2007-08-07 00:00:00

abstract：:In this work, the in vivo degradation and tissue compatibility of a novel class of inherently fluorescent copolyanhydrides, P(dCPS:SA), were investigated. It was found that the degradation of the copolyanhydrides increased with the increase of SA content in the copolymers. The in vivo degradation rate of the copolymer...

journal_title：Macromolecular bioscience

authors： Fan J,Li Y,Jiang H,Tang G,Wang L

更新日期：2008-05-13 00:00:00

abstract：:In this work, it is first reported that the poly (3-hydroxybutyric acid) (PHB) oligomer with a few degrees of polymerization possesses effective antibacterial and antifungal properties. Two preparation methods for the PHB oligomer are described, namely, one-step ring-opening polymerization of β-butyrolactone and extra...

journal_title：Macromolecular bioscience

authors： Ma L,Zhang Z,Li J,Yang X,Fei B,Leung PHM,Tao X

更新日期：2019-05-01 00:00:00

abstract：:Surface structural characterisation of three different starch-based blends (with poly[ethylene-co-(vinyl alcohol)], cellulose acetate and polycaprolactone) was carried out. The results show that there is a difference between the bulk and the surface composition of all studied blends. Two different hypotheses were inve...

journal_title：Macromolecular bioscience

authors： Pashkuleva I,Azevedo HS,Reis RL

更新日期：2008-02-11 00:00:00

abstract：:Uniform chitosan microspheres have been fabricated and weakly crosslinked for potential applications in colon-specific drug delivery. The effects of microsphere size, crosslinking density and electrostatic interactions between the drug and chitosan on drug release were studied, employing model drugs of different acidi...

journal_title：Macromolecular bioscience

authors： Choy YB,Cheng F,Choi H,Kim KK

更新日期：2008-12-08 00:00:00

abstract：:The enzymatic transformation into an oligomer was carried out with the objective of developing the chemical recycling of bacterial polyesters. Poly(R-3-hydroxyalkanoate)s (PHAs), such as poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyhexanoate)] and poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyvalerate)], were degraded ...

journal_title：Macromolecular bioscience

authors： Kaihara S,Osanai Y,Nishikawa K,Toshima K,Doi Y,Matsumura S

更新日期：2005-07-14 00:00:00

abstract：:The use of glycopolymer-functionalized resins (Resin-Glc), as a solid support, in column mode for bacterial/protein capture and quantification is explored. The Resin-Glc is synthesized from commercially available chloromethylated polystyrene resin and glycopolymer, and is characterized by fourier transform infrared sp...

journal_title：Macromolecular bioscience

authors： Ajish JK,Abraham HM,Subramanian M,Kumar KSA

更新日期：2020-12-18 00:00:00

abstract：:Biocompatible polymeric coatings for metallic stents are desired, as currently used materials present limitations such as deformation during degradation and exponential loss of mechanical properties after implantation. These concerns, together with the present risks of the drug-eluting stents, namely, thrombosis and r...

journal_title：Macromolecular bioscience

authors： Navarro L,Mogosanu DE,de Jong T,Bakker AD,Schaubroeck D,Luna J,Rintoul I,Vanfleteren J,Dubruel P

更新日期：2016-11-01 00:00:00

abstract：:Redox-responsive micelles are versatile nanoplatforms for on-demand drug delivery, but the in situ evaluation of drug release is challenging. Fluorescence resonance energy transfer (FRET) technique shows potential for addressing this, while the aggregation-caused quenching effect limits the assay sensitivity. The aim ...

journal_title：Macromolecular bioscience

authors： Wang X,Li J,Yan Q,Chen Y,Fan A,Wang Z,Zhao Y

更新日期：2018-03-01 00:00:00

abstract：:An electroactive amino/carboxyl-capped aniline tetramer (AT) is covalently grafted to the surface of hydroxyapatite (HA) nanoparticles to generate novel electroactive HA-AT nanoparticles. The amount of AT ranges from 16.5 to 34.0 wt% and is characterized by thermogravimetric analysis (TGA). The HA-AT nanoparticles are...

journal_title：Macromolecular bioscience

authors： Liu Y,Cui H,Zhuang X,Zhang P,Cui Y,Wang X,Wei Y,Chen X

更新日期：2013-03-01 00:00:00

abstract：:This study presents the reactive self-assembly of isocyanate functional and amphiphilic six-arm, star-shaped polyether prepolymers in water into nanogels. Intrinsic molecular amphiphilicity, mainly driven by the isophorone moiety at the distal endings of the star-shaped molecules, allows for the preparation of spheric...

journal_title：Macromolecular bioscience

authors： Hildebrandt H,Paloheimo O,Mäntylä E,Willman S,Hakanen S,Albrecht K,Groll J,Möller M,Vihinen-Ranta M

更新日期：2018-10-01 00:00:00

abstract：:Microspheres of amphiphilic multi-block poly(ester-ether)s (PEE)s and poly(ester-ether-amide)s (PEEA)s based on poly(epsilon-caprolactone) (PCL) were investigated as delivery systems for proteins. The interest was mainly focused on the effect of their molecular structure and composition on the overall properties of th...

journal_title：Macromolecular bioscience

authors： Quaglia F,Ostacolo L,Nese G,De Rosa G,La Rotonda MI,Palumbo R,Maglio G

更新日期：2005-10-20 00:00:00

abstract：:Herein, a new series of non-ionic dendritic and carbohydrate based amphiphiles is synthesized employing biocompatible starting materials and studied for supramolecular aggregate formation in aqueous solution. The dendritic amphiphiles 12 and 13 possessing poly(glycerol) [G2.0] as hydrophilic unit and C-10 and C-18 hyd...

journal_title：Macromolecular bioscience

authors： Prasad S,Achazi K,Schade B,Haag R,Sharma SK

更新日期：2018-07-01 00:00:00

abstract：:Current approaches to generate core-shell nanoparticles for biomedical applications are limited by factors such as synthetic scalability and circulatory desorption of cytotoxic surfactants. Developments in controlled radical polymerization, particularly in dispersed states, represent a promising method of overcoming t...

journal_title：Macromolecular bioscience

authors： Gurnani P,Sanchez-Cano C,Abraham K,Xandri-Monje H,Cook AB,Hartlieb M,Lévi F,Dallmann R,Perrier S

更新日期：2018-10-01 00:00:00

abstract：:In the last decade, substantial research in the field of post-plasma grafting surface modification has focussed on the introduction of carboxylic acids on surfaces by grafting acrylic acid (AAc). In the present work, we report on an alternative approach for biomaterial surface functionalisation. Thin poly-ε-caprolacto...

journal_title：Macromolecular bioscience

authors： Desmet T,Billiet T,Berneel E,Cornelissen R,Schaubroeck D,Schacht E,Dubruel P

更新日期：2010-12-08 00:00:00

abstract：:Chitosan is non-toxic, biocompatible, and biodegradable polysaccharide from renewable resources, known to have inherent antibacterial activity, which is mainly due to its polycationic nature. The combining of all assets of chitosan and its derivatives with the unique properties of electrospun nanofibrous materials is ...

journal_title：Macromolecular bioscience

authors： Ignatova M,Manolova N,Rashkov I

更新日期：2013-07-01 00:00:00

abstract：:The use of sugar-functionalized polyplexes as a nonviral gene delivery vector with lower cytotoxicity than the well-known polymeric carrier branched polyethyleneimine (BPEI) is investigated. The substitution of primary amine groups in the BPEI chains with lactose residues leads to larger polyplexes, presumably due to ...

journal_title：Macromolecular bioscience

authors： Albuquerque LJC,Alavarse AC,Carlan da Silva MC,Zilse MS,Barth MT,Bellettini IC,Giacomelli FC

更新日期：2018-02-01 00:00:00

abstract：:In the present study, a pH responsive dendritic polyglycerol nanogel (dPG-NG) is developed to measure the pH values inside the hair follicle (HF) using an ex vivo porcine ear model. The macromolecular precursors are labeled with a pH sensitive indodicarbocyanine dye (pH-IDCC) and a control dye (indocarbocyanine dye: I...

journal_title：Macromolecular bioscience

authors： Dimde M,Sahle FF,Wycisk V,Steinhilber D,Camacho LC,Licha K,Lademann J,Haag R

更新日期：2017-10-01 00:00:00

abstract：:Highly crystalline amylose-polytetrahydrofuran (PTHF) complexes can be obtained by employing organic solvents as washing agents after complex formation. The X-ray diffraction (XRD) of the washed complexes appear sharp at 12.9°-13.2° and 19.6°-20.1°, clear signs of the presence of V6I -amylose. Other diffraction peaks ...

journal_title：Macromolecular bioscience

authors： Rachmawati R,Woortman AJ,Loos K

更新日期：2014-01-01 00:00:00

abstract：:Numerous hydrogel-based culture systems are used to create in vitro model for prevascularization. Hydrogels used to induce a microenvironment conducive to microvessel formation are typically soft and fast degradable, but often suffer from maintaining a lasting perfusable channel in vitro. Here, a dual hydrogel system ...

journal_title：Macromolecular bioscience

authors： Kim S,Pan CC,Yang YP

更新日期：2020-10-01 00:00:00

abstract：:Cell adhesion to a scaffold is a prerequisite for tissue engineering. Many studies have been focused on enhancing cell adhesion to synthetic materials that are used for scaffold fabrication. In this study, we applied an avidin-biotin binding system to enhance chondrocyte adhesion to biodegradable polymers. Biotin mole...

journal_title：Macromolecular bioscience

authors： Tsai WB,Wang MC

更新日期：2005-03-15 00:00:00

abstract：:Stereoblock poly(lactic acid) consisting of D- and L-lactate stereosequences can be successfully synthesized by solid-state polycondensation of a 1:1 mixture of poly(L-lactic acid) and poly(D-lactic acid). In the first step, melt-polycondensation of L- and D-lactic acids is conducted to synthesize poly(L-lactic acid) ...

journal_title：Macromolecular bioscience

authors： Fukushima K,Furuhashi Y,Sogo K,Miura S,Kimura Y

更新日期：2005-01-14 00:00:00

abstract：:Biopolymers are an attractive class of compounds for being used in biomedical applications as they are widely available from biomass. Their drawback is the lack of mechanical stability and the ability to tune this properly. Covalent chemical cross-linking is an often used approach but it limits usability due to legisl...

journal_title：Macromolecular bioscience

authors： Kühn PT,Meijer TL,Schiavon I,van Poll M,van Aken J,Groen S,Kuijer R,van Kooten TG,van Rijn P

更新日期：2016-11-01 00:00:00

abstract：:Accurate prediction and validation of the assembly of bioinspired peptide sequences into fibers with defined mechanical characteristics would aid significantly in designing and creating materials with desired properties. This process may also be utilized to provide insight into how the molecular architecture of many n...

journal_title：Macromolecular bioscience

authors： Jacobsen MM,Tokareva OS,Ebrahimi D,Huang W,Ling S,Dinjaski N,Li D,Simon M,Staii C,Buehler MJ,Kaplan DL,Wong JY

更新日期：2017-09-01 00:00:00

abstract：:This study aims to develop an effective method to control motile microorganisms and enable their manipulation as functional 'live micro/nano robots'. A novel strategy based on Fe3 O4 nanoparticle-doped alginate hydrogel is developed to fashion an artificial extracellular matrix (ECM) for microbial cells (e.g., Sacchar...

journal_title：Macromolecular bioscience

authors： Shi X,Shi Z,Wang D,Ullah MW,Yang G

更新日期：2016-10-01 00:00:00

abstract：:Extraction processes of natural fibers can be performed by different procedures that include mechanical, chemical and biological methods. Each method presents different advantages or drawbacks according to the amount of fiber produced or the quality and properties of fiber bundles obtained. In this study, biological n...

journal_title：Macromolecular bioscience

authors： Gañán P,Zuluaga R,Velez JM,Mondragon I

更新日期：2004-10-20 00:00:00

abstract：:An arginine-leucine block copolypeptide (R60 L20 ) is synthesized, which is capable of forming vesicles with controllable sizes, able to transport hydrophilic cargo across the cell membrane, and exhibit relatively low cytotoxicity. The R60 L20 vesicles also possess the ability to deliver DNA into mammalian cells for t...

journal_title：Macromolecular bioscience

authors： Sun VZ,Choe UJ,Rodriguez AR,Dai H,Deming TJ,Kamei DT

更新日期：2013-05-01 00:00:00