Abstract:
:Peptide dendrimers assembled by solid-phase peptide synthesis using a branching diamino acid at every 2(nd) or 3(rd) position provide readily accessible synthetic model systems for proteins and enzymes. They adopt a globular shape by topology rather than by folding. Peptide dendrimers of 2(nd) and 3(rd) generation functionalized with a cysteine or cystine residue in the core were adsorbed on Au(111) surface and imaged by STM at air, under UHV, or in solution. The dendrimers appear as globular features with dimensions suggesting an extended flattened conformation, forming both single globules and ordered arrays on the surface. These images represent the first direct visualization of peptide dendrimer enzyme models.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Delort E,Szöcs E,Widmer R,Siegenthaler H,Reymond JLdoi
10.1002/mabi.200700036subject
Has Abstractpub_date
2007-08-07 00:00:00pages
1024-31issue
8eissn
1616-5187issn
1616-5195journal_volume
7pub_type
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