Abstract:
:Multicellular tumor spheroid (MCTS) mimics microenvironment for tumor formation and provides predictive insight for in vivo tests. The hanging drop (HD) method of spheroid generation is cost effective, but it is limited by a long time duration for spheroid development and a low rate of formation of larger spheroids. Toward addressing those limitations, thermoresponsive copolymers with poly(N-isopropylacrylamide) (p(NIPA)) backbone are developed, to be used as additives in the MCTS formation via HD method. Upon investigation it is found that in the presence of the polymer, robust and compact spheroids are formed in a short duration of 48 h. Larger spheroids (350-600 µm) can be formed by increasing the number of cells. Spheroids are characterized for their 3D shape and different cellular layers, and drug uptake study is done to prove the efficacy of the spheroids generated in drug screening.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
R A V,Kumari S,Poddar P,Dhara D,Maiti Sdoi
10.1002/mabi.202000180subject
Has Abstractpub_date
2020-08-01 00:00:00pages
e2000180issue
8eissn
1616-5187issn
1616-5195journal_volume
20pub_type
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