Abstract:
:Hyperbranched polyurethanes are synthesized using TDI, PCL diol, butanediol, and pentaerythritol (1-5 wt%) as the B(4) reactant with and without the monoglyceride of sunflower oil. The biodegradation, physico-mechanical, and thermal properties are found to be tailored by varying the percentage weight of the branching unit. An MTT/hemolytic assay and subcutaneous implantation in Wistar rats followed by cytokine/ALP assay and histopathology studies confirm a better biocompatibility of HBPU with MG than without MG. HBPU supports the proliferation of dermatocytes with no toxic effect in major organs, in addition the in vitro degraded products are non-toxic. Cell adherence and proliferation endorse the bio-based HBPU as a prospective scaffold material in the niche of tissue engineering.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Das B,Chattopadhyay P,Mandal M,Voit B,Karak Ndoi
10.1002/mabi.201200244subject
Has Abstractpub_date
2013-01-01 00:00:00pages
126-39issue
1eissn
1616-5187issn
1616-5195journal_volume
13pub_type
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