Reducible Polyethylenimine Nanoparticles for Efficient siRNA Delivery in Corneal Neovascularization Therapy.

abstract：:Open-pore biodegradable foams with controlled porous architectures were prepared by combining gas foaming and microparticulate templating. Microparticulate composites of poly(epsilon-caprolactone) (PCL) and micrometric sodium chloride particles (NaCl), in concentrations ranging from 70/30 to 20/80 wt.-% of PCL/NaCl we...

journal_title：Macromolecular bioscience

authors： Salerno A,Iannace S,Netti PA

更新日期：2008-07-07 00:00:00

abstract：:Formulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes using a simple and reproducible nanoprecipitation method. The prepared DOC loaded polymersomes (PolyDOC) was stable either in solution or in a lyophilized form, and s...

journal_title：Macromolecular bioscience

authors： Upadhyay KK,Bhatt AN,Castro E,Mishra AK,Chuttani K,Dwarakanath BS,Schatz C,Le Meins JF,Misra A,Lecommandoux S

更新日期：2010-05-14 00:00:00

abstract：:Extraction processes of natural fibers can be performed by different procedures that include mechanical, chemical and biological methods. Each method presents different advantages or drawbacks according to the amount of fiber produced or the quality and properties of fiber bundles obtained. In this study, biological n...

journal_title：Macromolecular bioscience

authors： Gañán P,Zuluaga R,Velez JM,Mondragon I

更新日期：2004-10-20 00:00:00

abstract：:Since the early 1980s, research on the modification of bone implant surfaces by applying coatings has mainly focused on the application of inorganic calcium phosphate (CaP) coatings using physical deposition techniques. Organic components of the extracellular bone matrix, on the other hand, play an essential role in t...

journal_title：Macromolecular bioscience

authors： Nijhuis AW,Leeuwenburgh SC,Jansen JA

更新日期：2010-11-10 00:00:00

abstract：:Biodegradable hydrogels were synthesized by the click reaction of 4-arm azido-terminated PEG differing in molecular weight (2,100 and 8,800) and two alkyne-terminated peptides: [alkyne]-GFLGK-[alkyne] and ([alkyne]-GFLG)(2)K. The physical properties of in situ formed hydrogels were examined. The hydrogels were highly ...

journal_title：Macromolecular bioscience

authors： Yang J,Jacobsen MT,Pan H,Kopecek J

更新日期：2010-04-08 00:00:00

abstract：:We report on a novel series of biomimetic polymers exhibiting interfacial properties similar to the extracellular matrix. A series of well-defined surfactant polymers were synthesized by simultaneously incorporating arginine-glycine-aspartic acid (RGD) peptide, dextran oligosaccharide, and hexyl ligands with controlle...

journal_title：Macromolecular bioscience

authors： Anderson EH,Ruegsegger MA,Murugesan G,Kottke-Marchant K,Marchant RE

更新日期：2004-08-09 00:00:00

abstract：:Different strategies of chemotherapeutics-based combination cancer therapy have presented enhanced antitumor efficiency and are widely used in clinical cancer treatments. However, several drawbacks of the systems for systemic administration, including low drug accumulation at tumor sites and significant systemic side ...

journal_title：Macromolecular bioscience

authors： Yu S,He C,Chen X

更新日期：2018-12-01 00:00:00

abstract：:Tissue damage caused by excessive amounts of neutrophil-derived reactive oxygen species (ROS) occurs in many inflammatory diseases. Butyrate is a short-chain fatty acid (SCFA) with known anti-inflammatory properties, able to modulate several neutrophil functions. Evidence is provided here that butyrate inhibits neutro...

journal_title：Macromolecular bioscience

authors： Sacco P,Decleva E,Tentor F,Menegazzi R,Borgogna M,Paoletti S,Kristiansen KA,Vårum KM,Marsich E

更新日期：2017-11-01 00:00:00

abstract：:Photo-crosslinking and self-healing have received considerable attention for the design of intelligent materials. A novel photostimulated, self-healing, and cytocompatible hydrogel system is reported. A coumarin methacrylate crosslinker is synthesized to modify the polyacrylamide-based hydrogels. With the [2+2] cyclo-...

journal_title：Macromolecular bioscience

authors： Yu L,Xu K,Ge L,Wan W,Darabi A,Xing M,Zhong W

更新日期：2016-09-01 00:00:00

abstract：:A poly(o-methoxyaniline) (POMA)/DNA [weight fraction of DNA (W(DNA)) = 0.45] hybrid was prepared by mixing their solutions in sterilized double distilled water. The solution turned green upon aging for a longer time, and the doping of POMA by DNA was complete after about 15 d of aging. The doping was confirmed from th...

journal_title：Macromolecular bioscience

authors： Dawn A,Nandi AK

更新日期：2005-05-23 00:00:00

abstract：:N-Acetyl-l-cysteine (NAC)-capped poly(methyl methacrylate)-b-polycaprolactone block copolymer (PMMA-b-PCL-NAC) was prepared using the previously described one-pot photoinduced sequential CuAAC/thiol-ene double click procedure. PMMA-b-PCL-NAC had previously shown good applicability as a matrix for cell adhesion of cell...

journal_title：Macromolecular bioscience

authors： Oyman Eyrilmez G,Doran S,Murtezi E,Demir B,Odaci Demirkol D,Coskunol H,Timur S,Yagci Y

更新日期：2015-09-01 00:00:00

abstract：:Emphasizing the role of hydrogel stiffness and cellular differentiation, this study develops collagen and elastin-like polypeptide (ELP)-based bone regenerative hydrogels loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2) and doxycycline with mechanical properties suitable for osteogenesis. The drug-...

journal_title：Macromolecular bioscience

authors： Pal P,Nguyen QC,Benton AH,Marquart ME,Janorkar AV

更新日期：2019-09-01 00:00:00

abstract：:Previously synthesized amphiphilic diblock copolymers with pendant dendron moieties have been investigated for their potential use as drug carriers to improve the delivery of an anticancer drug to human breast cancer cells. Diblock copolymer (P71 D3 )-based micelles effectively encapsulate the doxorubicin (DOX) with a...

journal_title：Macromolecular bioscience

authors： Viswanathan G,Hsu YH,Voon SH,Imae T,Siriviriyanun A,Lee HB,Kiew LV,Chung LY,Yusa S

更新日期：2016-06-01 00:00:00

abstract：:Thermosensitive polymers enable externally controllable biomolecular interactions but hysteresis effects hamper the reversibility and repeated use of these materials. To quantify the temperature-dependent interactions and hysteresis effects, an optical adhesion assay based on poly(ethylene glycol) microgels (soft coll...

journal_title：Macromolecular bioscience

authors： Strzelczyk AK,Paul TJ,Schmidt S

更新日期：2020-10-01 00:00:00

abstract：:Polylaminin (polyLM) is a polymerized form of the extracellular matrix protein laminin obtained upon pH acidification. Here microscopy and spectroscopic tools are used to study the cell compatibility and the structural stability of polyLM, aiming at establishing its robustness as a biopolymer for therapeutic use. Poly...

journal_title：Macromolecular bioscience

authors： Freire E,Barroso MM,Klier RN,Coelho-Sampaio T

更新日期：2012-01-01 00:00:00

abstract：:Pulmonary air leaks are medical complications of thoracic surgery for which fibrin sealant is the main treatment. In this study, innovative sealants based on hydrophobically modified Alaska pollock-derived gelatin (hm-ApGltn) and a poly(ethylene)glycol-based 4-armed cross-linker (4S-PEG) have been developed and their ...

journal_title：Macromolecular bioscience

authors： Mizuta R,Taguchi T

更新日期：2017-04-01 00:00:00

abstract：:For use in micro-patterned scaffolds in tissue engineering, novel diacrylated triblock macromers (PLA-b-PCL-b-PLA, PGA-b-PCL-b-PGA and PCL-b-PEO-b-PCL) were synthesized and characterized by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (NMR) and gel permeation chromatography (...

journal_title：Macromolecular bioscience

authors： Chan-Park MB,Zhu AP,Shen JY,Fan AL

更新日期：2004-07-14 00:00:00

abstract：:The amyloid-β peptide (Aβ) plays a central role in the mechanism of Alzheimer's disease, being the main constituent of the plaque deposits found in AD brains. Aβ amyloid formation and deposition are due to a conformational switching to a β-enriched secondary structure. Our strategy to inhibit Aβ aggregation involves t...

journal_title：Macromolecular bioscience

authors： Saraiva AM,Cardoso I,Saraiva MJ,Tauer K,Pereira MC,Coelho MA,Möhwald H,Brezesinski G

更新日期：2010-10-08 00:00:00

abstract：:Ischemic stroke occurs when a blood clot obstructs or narrows the arteries that supply blood to the brain. Currently, tissue plasminogen activator (tPA), a thrombolytic agent, is the only United States Food and Drug Administration (FDA)-approved pharmacologic treatment for ischemic stroke. Despite its effective usage,...

journal_title：Macromolecular bioscience

authors： Vankayala R,Corber SR,Mac JT,Rao MP,Shafie M,Anvari B

更新日期：2018-04-01 00:00:00

abstract：:Cells in physiological 3D environments differ considerably in morphology and differentiation from those in 2D tissue culture. Naturally derived polymer systems are frequently used to study cells in 3D. These 3D matrices are complex with respect to their chemical composition, mechanical properties, and geometry. Theref...

journal_title：Macromolecular bioscience

authors： Greiner AM,Richter B,Bastmeyer M

更新日期：2012-10-01 00:00:00

abstract：:In drug delivery to the human brain, blood vessels are a significant hurdle because they restrict the entry of most solutes to protect brain. To overcome this hurdle, an in vitro 3D model for brain endothelial barrier is developed using a microfluidic device with hydrogel providing a 3D extracellular matrix scaffold. ...

journal_title：Macromolecular bioscience

authors： Chung B,Kim J,Nam J,Kim H,Jeong Y,Liu HW,Cho Y,Kim YH,Oh HJ,Chung S

更新日期：2020-06-01 00:00:00

abstract：:Enzyme immobilization is of high interest for industrial applications. However, immobilization may compromise enzyme activity or stability due to the harsh conditions which have to be applied. The authors therefore present a new and improved crosslinked layer-by-layer (cLbL) approach. Two different model enzymes (acid...

journal_title：Macromolecular bioscience

authors： Sieber S,Siegrist S,Schwarz S,Porta F,Schenk SH,Huwyler J

更新日期：2017-08-01 00:00:00

abstract：:When lysozyme is dissolved in a neutral HEPES buffer solution (pH = 7.4) with 0.001-0.050 M TCEP added, a fast phase transition process occurs and the resulting novel fiber-like hierarchical supramolecular assemblies made by primary spherical-particle aggregation can function as a "superglue" that binds strongly and q...

journal_title：Macromolecular bioscience

authors： Yang P

更新日期：2012-08-01 00:00:00

abstract：:The synthesis of a novel nanocapsule-based carrier system is described, possessing a triggered release in remote-controlled fashion upon application of an external magnetic field in combination with the possibility to use the capsules as contrast agents for magnetic resonance imaging (MRI). Therefore, polymeric nanoco...

journal_title：Macromolecular bioscience

authors： Bannwarth MB,Ebert S,Lauck M,Ziener U,Tomcin S,Jakob G,Münnemann K,Mailänder V,Musyanovych A,Landfester K

更新日期：2014-09-01 00:00:00

abstract：:Mucoadhesive NP drug carriers have attracted substantial interest as a potential treatment for anterior eye diseases. NPs composed of PLA-Dex surface functionalized with a mucoadhesive ligand, PBA, were developed as drug carriers with particle sizes ranging from 25 to 28 nm. Using CycA as a model drug, we showed that ...

journal_title：Macromolecular bioscience

authors： Liu S,Jones L,Gu FX

更新日期：2012-12-01 00:00:00

abstract：:Plant derived flavonoids have not been well explored in tissue engineering applications due to difficulties in efficient formulations with biomaterials for controlled presentation. Here, the authors report that surface coating of epigallocatechin gallate (EGCG) on polymeric substrates including poly (L-lactic acid) (P...

journal_title：Macromolecular bioscience

authors： Madhurakkat Perikamana SK,Lee SM,Lee J,Ahmad T,Lee MS,Yang HS,Shin H

更新日期：2019-04-01 00:00:00

abstract：:Transparent, biodegradable, mechanically robust, and surface-patterned silk films were evaluated for the effect of surface morphology on human corneal fibroblast (hCF) cell proliferation, orientation, and ECM deposition and alignment. A series of dimensionally different surface groove patterns were prepared from optic...

journal_title：Macromolecular bioscience

authors： Gil ES,Park SH,Marchant J,Omenetto F,Kaplan DL

更新日期：2010-06-11 00:00:00

abstract：:Microbial transglutaminase (mTG) and mushroom tyrosinase (MT) are used to crosslink B. mori silk fibroin/gelatin (SF/G) films. Crosslinked and uncrosslinked SF/G films show no phase separation. The thermal behavior and the conformational structure of SF/G films are strongly affected by blending and enzymatic treatment...

journal_title：Macromolecular bioscience

authors： Taddei P,Chiono V,Anghileri A,Vozzi G,Freddi G,Ciardelli G

更新日期：2013-11-01 00:00:00

abstract：:Shape memory polymers (SMPs) are a class of polymeric materials used in various medical interventions such as vascular stents. In this work, two SMPs, thermoplastic (TP) and thermoset (TS), have been measured in vitro for the degree of cellular and protein adhesion, their ability to stimulate inflammatory cytokine pro...

journal_title：Macromolecular bioscience

authors： Cabanlit M,Maitland D,Wilson T,Simon S,Wun T,Gershwin ME,Van de Water J

更新日期：2007-01-05 00:00:00

abstract：:A ternary complex comprising plasmid DNA, lipopolysaccharide-binding peptide (LBP), and deoxycholic acid-conjugated polyethylenimine (PEI-DA) is prepared for combinational therapy of acute lung injury (ALI). The LBP is designed as an anti-inflammatory peptide based on the lipopolysaccharide (LPS)-binding domain of HMG...

journal_title：Macromolecular bioscience

authors： Kim JY,Piao C,Kim G,Lee S,Lee MS,Jeong JH,Lee M

更新日期：2017-08-01 00:00:00