Abstract:
:A CMB monomer was polymerized on a glass plate with a surface-confined ATRP initiator containing a 2-bromoisobutyryl group. The glass plate modified with a PCMB brush was highly hydrophilic and showed a strong resistance against non-specific adsorption of proteins and cell adhesion. Upon ion beam irradiation, furthermore, the PCMB brush was ablated and a hollow space with a designed shape could be made to which HEK293 cells (from human embryonic kidney) and Hep G2 (from human hepatoma) cells non-specifically adhered, while no adhesion of these cells to the non-treated area on the brush was observed. The present results clearly indicate the usefulness of ion beam-printed patterns of anti-biofouling zwitterionic polymer brushes in the biomedical field.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Kitano H,Suzuki H,Kondo T,Sasaki K,Iwanaga S,Nakamura M,Ohno K,Saruwatari Ydoi
10.1002/mabi.201000437subject
Has Abstractpub_date
2011-04-08 00:00:00pages
557-64issue
4eissn
1616-5187issn
1616-5195journal_volume
11pub_type
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