Abstract:
:Comb-shaped glycopolymer/peptide bioconjugates are constructed by grafting reduced glutathione (GSH) onto acrylate-functional block glycocopolymers via thiol-ene click chemistry. In aqueous solution, the glycopolymer/GSH bioconjugate self-assembles to sugar-installed spherical micelles. The size of micelles decreases with increasing pH, demonstrating pH-responsive character. The isoelectric point (IEP) of the PMAGlc/GSH bioconjugate is estimated to be 3.43. The micelles show a specific interaction with the protein Concanavalin A. At endosomal pH, the PMAGlc/GSH bioconjugate can gradually degrade. These pH-responsive glycopolymer/peptide micelles with biological recognition and degradation can be used as multifunctional nanocarriers for targeted drug delivery.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Wang X,Liu L,Luo Y,Shi H,Li J,Zhao Hdoi
10.1002/mabi.201200274subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1575-82issue
11eissn
1616-5187issn
1616-5195journal_volume
12pub_type
杂志文章abstract::The use of long-lasting polymer coatings on biodevice surfaces has been investigated to improve material-tissue interaction, minimize adverse effects, and enhance their functionality. Natural polymers, especially chitosan, are of particular interest due to their excellent biological properties, such as biocompatibilit...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201900253
更新日期:2020-01-01 00:00:00
abstract::Ischemic stroke occurs when a blood clot obstructs or narrows the arteries that supply blood to the brain. Currently, tissue plasminogen activator (tPA), a thrombolytic agent, is the only United States Food and Drug Administration (FDA)-approved pharmacologic treatment for ischemic stroke. Despite its effective usage,...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700379
更新日期:2018-04-01 00:00:00
abstract::Multifunctional polymers with defined structure and biocompatibility are critical to the development of drug delivery systems and bioconjugates. In this article, the synthesis, in vitro blood compatibility, cell viability, in vivo circulation, biodistribution, and clearance of hybrid copolymers based on linear and bra...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400152
更新日期:2014-10-01 00:00:00
abstract::Redox-responsive micelles are versatile nanoplatforms for on-demand drug delivery, but the in situ evaluation of drug release is challenging. Fluorescence resonance energy transfer (FRET) technique shows potential for addressing this, while the aggregation-caused quenching effect limits the assay sensitivity. The aim ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700339
更新日期:2018-03-01 00:00:00
abstract::Multivalent carbohydrate-lectin interactions play a crucial role in bacterial infection. Biomimicry of multivalent glycosystems represents a major strategy in the repression of bacterial growth. In this study, a new kind of glycopeptide (Naphthyl-Phe-Phe-Ser-Tyr, NMY) scaffold with mannose modification is designed and...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201900124
更新日期:2019-09-01 00:00:00
abstract::Highly crystalline amylose-polytetrahydrofuran (PTHF) complexes can be obtained by employing organic solvents as washing agents after complex formation. The X-ray diffraction (XRD) of the washed complexes appear sharp at 12.9°-13.2° and 19.6°-20.1°, clear signs of the presence of V6I -amylose. Other diffraction peaks ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201300174
更新日期:2014-01-01 00:00:00
abstract::Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters. Polymer concentration, UV exposure time, and thermal gelation prior to UV exposure allow for control over hydrogel stiffness...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200471
更新日期:2013-05-01 00:00:00
abstract::Since the early 1980s, research on the modification of bone implant surfaces by applying coatings has mainly focused on the application of inorganic calcium phosphate (CaP) coatings using physical deposition techniques. Organic components of the extracellular bone matrix, on the other hand, play an essential role in t...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201000142
更新日期:2010-11-10 00:00:00
abstract::In this work we report, compare and discuss the results obtained from fully atomistic molecular dynamics simulations of generations 4, 5, and 6 of PAMAM-based dendrimers having NH(3) and triethanolamine as cores, forming complexes with a short interfering RNA (siRNA) at different pH values and at physiological ionic ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100276
更新日期:2012-02-01 00:00:00
abstract::Recombinantly produced spider silk proteins have high potential for bioengineering and various biomedical applications because of their biocompatibility, biodegradability, and low immunogenicity. Here, the recently described small spider silk protein eMaSp1s is assembled into hydrogels, which can be 3D printed into sc...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700141
更新日期:2017-11-01 00:00:00
abstract::The immobilization of enzymes into polymer hydrogels is a versatile approach to improve their stability and utility in biotechnological and biomedical applications. However, these systems typically show limited enzyme activity, due to unfavorable pore dimensions and low enzyme accessibility. Here, 3D jet writing of wa...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000154
更新日期:2020-09-01 00:00:00
abstract::The core-shell micelles in aqueous solutions were prepared at low CAC values (<0.1 mg · mL(-1) ) from amphiphilic graft copolymers consisting of poly(methyl methacrylate) backbone (120-165 units) with loosely grafted (17-40%) hydroxyl-capped PEG (9 vs 6 units in side chain) for drug loading. Hydrophobic indomethacin (...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500189
更新日期:2015-11-01 00:00:00
abstract::O-carboxymethylchitin (molecular weight = 1.07 x 10(5), degree of carboxymethylation = 80%, degree of N-acetylation = 91%) was chemically attached to superoxide dismutase by the formation of amide linkages through a carbodiimide catalyzed reaction. The glycosidated enzyme contained about 1.8 mole of polysaccharide per...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400114
更新日期:2005-02-23 00:00:00
abstract::Shape memory polymers (SMPs) are a class of polymeric materials used in various medical interventions such as vascular stents. In this work, two SMPs, thermoplastic (TP) and thermoset (TS), have been measured in vitro for the degree of cellular and protein adhesion, their ability to stimulate inflammatory cytokine pro...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600177
更新日期:2007-01-05 00:00:00
abstract::A series of enzymatically recyclable poly(ester-urethane)s consisting of a biodegradable diurethane moiety as a hard segment and an ester moiety as an enzymatically cleavable linkage was chemo-enzymatically prepared by two routes. The poly(ester-urethane) was prepared by a) the ring-opening polymerization of a cyclic ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400176
更新日期:2005-04-19 00:00:00
abstract::Desferrioxamine (DFO) is a clinically approved, high affinity iron chelator used for the treatment of iron overload. Due to its short half-life and toxicity, DFO is administered for 8-12 h per day, 5-7 d per week. In this manuscript, the influence of molecular properties of hyperbranched polyglycerol (HPG)-DFO conjuga...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600244
更新日期:2017-03-01 00:00:00
abstract::Amino acid ester substituted polyphosphazenes are osteoactive benefiting from their phosphorus-containing chemical structure, which highlights interests in bone tissue engineering. To correlate their chemical structures with cell activities, in this study, poly[(ethyl alanato)0.3 (ethyl glycinato)0.7 phosphazene] (PAG...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800464
更新日期:2019-06-01 00:00:00
abstract::Aggregation of denatured or unfolded proteins establishes a large energy barrier to spontaneous recovery of protein form and function following traumatic injury, tissue cryopreservation, and biopharmaceutical storage. Some tissues utilize small heat shock proteins (sHSPs) to prevent irreversible aggregation, which all...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600217
更新日期:2017-02-01 00:00:00
abstract::A new anhydroribotrisaccharide monomer, A2B3LR (1), was synthesized and ROP was carried out to elucidate the polymerizability and to obtain oligosaccharide-branched polysaccharides with defined structures. The new trisaccharide monomer was found to be polymerized readily with BF(3) . OEt(2) as a catalyst at -40 degree...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800316
更新日期:2009-07-07 00:00:00
abstract::In situ self-assemblies of new biodegradable triblock PLLA-b-PBS-b-PLLA and PDLA-b-PBS-b-PDLA have been investigated in acetonitrile solution. At first, two series of PLLA-b-PBS-b-PLLA and PDLA-b-PBS-b-PDLA, respectively denoted as the P and Q triblock copolyester series, were prepared with fixed PBS block ((overline)...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400227
更新日期:2005-06-24 00:00:00
abstract::A facile and easily reproducible technique for assembling biohybrid nanoparticles is a core feature that is highly desired for biomedical applications, considering the nature and limited lifespan of the biopolymers used. Here we show a simple and effective method to enfold single-walled carbon nanotubes (SWNTs) using ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900349
更新日期:2010-03-10 00:00:00
abstract::The random copolymer, poly[lactide-co-glycotide-co-(epsilon-caprolactone)] (PLGACL) diacrylate was prepared by ring-opening polymerization of L-lactide, glycolide, and epsilon-caprolactone initiated with tetra(ethylene glycol). The diacrylated polymers were extensively characterized. With a UV embossing method, these ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200500168
更新日期:2006-01-05 00:00:00
abstract::Biocompatible polymeric coatings for metallic stents are desired, as currently used materials present limitations such as deformation during degradation and exponential loss of mechanical properties after implantation. These concerns, together with the present risks of the drug-eluting stents, namely, thrombosis and r...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600105
更新日期:2016-11-01 00:00:00
abstract::This paper presents the analysis of the volume phase transition of ionic thermo-sensitive hydrogels to thermal stimulus through mathematical modelling. The model is termed the multi-effect-coupling thermal-stimulus (MECtherm) model and it considers the effects of multi-phases and multi-physics. Its application to stea...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200500082
更新日期:2005-09-16 00:00:00
abstract::Polycations, mimicking activity of antibacterial peptides, belong to an important class of molecules investigated as a support or as an alternative to antibiotics. In this work, studies of modified linear amphiphilic statistical polymethyloxazoline (PMOX) and polyethyleneimine copolymers (PMOX_PEI) series are presente...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201900254
更新日期:2019-12-01 00:00:00
abstract::"Three-layered micelles" (3LM) composed of two triblock copolymers, poly(L-lactide)-b-polyethyleneimine-b-poly(L-lactide) (PLLA-PEI-PLLA) and poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) (PLLA-PEG-PLLA) are designed to combine electrostatic interaction and solvent-induced condensation of DNA. The low mole...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400488
更新日期:2015-05-01 00:00:00
abstract::Novel chitosan (CHS) and cellulose sulfates (CSs) are studied regarding their mitogenic activity and their protective effect against proteolytic digestion of FGF-2. An intermediate degree of sulfation (DS(S) ) and lower concentration of CHS have superior effect on 3T3 cell growth while the mitogenic activity of CS inc...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100518
更新日期:2012-06-01 00:00:00
abstract::Treatment of retinal diseases currently demands frequent intravitreal injections due to rapid clearance of the therapeutics. The use of high molecular weight polymers can extend the residence time in the vitreous and prolong the injection intervals. This study reports a water soluble graft copolymer as a potential veh...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700200
更新日期:2018-01-01 00:00:00
abstract::Poly(N-methylvinylamines) with secondary amines can form complexes with plasmid DNA (pDNA) and provide transfection efficiency in HeLa cells in the same order as linear polyethyleneimine but with higher cell viability. Chemical modifications of poly(N-methylvinylamine) backbones are performed to further improve transf...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700353
更新日期:2018-04-01 00:00:00
abstract::Integration of electrogenic microorganisms remains a challenge in biofuel cell technology. Here, synthetic biocomposites ("artificial biofilms") are proposed. Bacteria (Shewanella oneidensis) are embedded in a hydrogel matrix (poly(vinyl alcohol)) via wet- and electrospinning, creating fibers and nonwoven gauzes. The ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600442
更新日期:2017-07-01 00:00:00