Thermohydrogel Containing Melanin for Photothermal Cancer Therapy.

Abstract:

:Melanin is an effective absorber of light and can extend to near infrared (NIR) regions. In this study, a natural melanin is presented as a photothermal therapeutic agent (PTA) because it provides a good photothermal conversion efficiency, shows biodegradability, and does not induce long-term toxicity during retention in vivo. Poloxamer solution containing melanin (Pol-Mel) does not show any precipitation and shows sol-gel transition at body temperature. After irradiation from 808 nm NIR laser at 1.5 W cm-2 for 3 min, the photothermal conversion efficiency of Pol-Mel is enough to kill cancer cells in vitro and in vivo. The tumor growth of mice bearing CT26 tumors treated with Pol-Mel injection and laser irradiation is suppressed completely without recurrence postirradiation. All these results indicate that Pol-Mel can become an attractive PTA for photothermal cancer therapy.

journal_name

Macromol Biosci

authors

Kim M,Kim HS,Kim MA,Ryu H,Jeong HJ,Lee CM

doi

10.1002/mabi.201600371

subject

Has Abstract

pub_date

2017-05-01 00:00:00

issue

5

eissn

1616-5187

issn

1616-5195

journal_volume

17

pub_type

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