Development of mucoadhesive drug delivery system using phenylboronic acid functionalized poly(D,L-lactide)-b-dextran nanoparticles.

abstract：:Over the past few decades, numerous polymer drug carrier systems are designed and synthesized, and their properties are evaluated. Many of these systems are based on water-soluble polymer carriers of low-molecular-weight drugs and compounds, e.g., cytostatic agents, anti-inflammatory drugs, or multidrug resistance inh...

journal_title：Macromolecular bioscience

authors： Chytil P,Koziolová E,Etrych T,Ulbrich K

更新日期：2018-01-01 00:00:00

abstract：:Vessel morphogenesis is vital to regenerative medicine strategies. Here, collagen polymers, specified by intermolecular cross-link composition, are used to independently vary microstructure (fibril density, interfibril branching) and physical properties (stiffness) to guide 3D vessel network formation by endothelial c...

journal_title：Macromolecular bioscience

authors： Whittington CF,Yoder MC,Voytik-Harbin SL

更新日期：2013-09-01 00:00:00

abstract：:In this work, it is first reported that the poly (3-hydroxybutyric acid) (PHB) oligomer with a few degrees of polymerization possesses effective antibacterial and antifungal properties. Two preparation methods for the PHB oligomer are described, namely, one-step ring-opening polymerization of β-butyrolactone and extra...

journal_title：Macromolecular bioscience

authors： Ma L,Zhang Z,Li J,Yang X,Fei B,Leung PHM,Tao X

更新日期：2019-05-01 00:00:00

abstract：:Previously synthesized amphiphilic diblock copolymers with pendant dendron moieties have been investigated for their potential use as drug carriers to improve the delivery of an anticancer drug to human breast cancer cells. Diblock copolymer (P71 D3 )-based micelles effectively encapsulate the doxorubicin (DOX) with a...

journal_title：Macromolecular bioscience

authors： Viswanathan G,Hsu YH,Voon SH,Imae T,Siriviriyanun A,Lee HB,Kiew LV,Chung LY,Yusa S

更新日期：2016-06-01 00:00:00

abstract：:O-carboxymethylchitin (molecular weight = 1.07 x 10(5), degree of carboxymethylation = 80%, degree of N-acetylation = 91%) was chemically attached to superoxide dismutase by the formation of amide linkages through a carbodiimide catalyzed reaction. The glycosidated enzyme contained about 1.8 mole of polysaccharide per...

journal_title：Macromolecular bioscience

authors： Valdivia A,Perez Y,Dominguez A,Caballero J,Gomez L,Schacht EH,Villalonga R

更新日期：2005-02-23 00:00:00

abstract：:In this study we formed and characterized dynamic hydrogel microspheres in which a protein conformational change was used to control microsphere volume changes and the release of an encapsulated drug. In particular, a specific biochemical ligand, trifluoperazine, induced calmodulin's nanometer scale conformation chang...

journal_title：Macromolecular bioscience

authors： King WJ,Pytel NJ,Ng K,Murphy WL

更新日期：2010-06-11 00:00:00

abstract：:Current approaches to generate core-shell nanoparticles for biomedical applications are limited by factors such as synthetic scalability and circulatory desorption of cytotoxic surfactants. Developments in controlled radical polymerization, particularly in dispersed states, represent a promising method of overcoming t...

journal_title：Macromolecular bioscience

authors： Gurnani P,Sanchez-Cano C,Abraham K,Xandri-Monje H,Cook AB,Hartlieb M,Lévi F,Dallmann R,Perrier S

更新日期：2018-10-01 00:00:00

abstract：:Well-defined amphiphilic polymers of the ABA and ABC type are synthesized, where A is poly(L-lysine hydrochloride) (PLL), B is poly(γ-benzyl-(d7) L-glutamate) (PBLG(-d7)), and C is poly(ethylene oxide) (PEO). The two polymers exhibit similar PBLG(-d7) composition, while in the ABC, the volume fraction of PEO block is ...

journal_title：Macromolecular bioscience

authors： Iatrou H,Dimas K,Gkikas M,Tsimblouli C,Sofianopoulou S

更新日期：2014-09-01 00:00:00

abstract：:The next-generation sutures should provide in situ monitoring of wound condition such as temperature while reducing surgical site infection during wound closure. In this study, functionalized nanodiamond (FND) and reduced graphene oxide (rGO) into biodegradable polycaprolactone (PCL) are incorporated to develop a new ...

journal_title：Macromolecular bioscience

authors： Houshyar S,Bhattacharyya A,Khalid A,Rifai A,Dekiwadia C,Kumar GS,Tran PA,Fox K

更新日期：2021-01-12 00:00:00

abstract：:An insoluble wheat proteins-based polymer networks with new functional groups and positive charges were prepared through grafting-coupling reactions. The networks were also flexible with a lower glass transition temperature since the existence of the grafted mobile segments. The multi-component/multi-phase systems bec...

journal_title：Macromolecular bioscience

authors： Kurniawan L,Qiao GG,Zhang X

更新日期：2009-01-09 00:00:00

abstract：:The present review is aimed at elucidating relatively new aspects of mucoadhesion/mucus interaction and related phenomena that emerged from a Mucoadhesion workshop held in Munster on 2-3 September 2015 as a satellite event of the ICCC 13th-EUCHIS 12th. After a brief outline of the new issues, the focus is on mucus des...

journal_title：Macromolecular bioscience

authors： Mackie AR,Goycoolea FM,Menchicchi B,Caramella CM,Saporito F,Lee S,Stephansen K,Chronakis IS,Hiorth M,Adamczak M,Waldner M,Nielsen HM,Marcelloni L

更新日期：2017-08-01 00:00:00

abstract：:Living materials are created through the embedding of live, whole cells into a matrix that can house and sustain the viability of the encapsulated cells. Through the immobilization of these cells, their bioactivity can be harnessed for applications such as bioreactors for the production of high-value chemicals. While ...

journal_title：Macromolecular bioscience

authors： Johnston TG,Fillman JP,Priks H,Butelmann T,Tamm T,Kumar R,Lahtvee PJ,Nelson A

更新日期：2020-08-01 00:00:00

abstract：:The biorecognition-based control of attachment/detachment of MCF-7 cancer cells from polymer-coated surfaces is demonstrated. A glass surface is coated with a thermoresponsive statistical copolymer of poly(N-isopropylacrylamide-co-acrylamide) [p(NIPAm-co-Am)], which is end-capped with the Gly-Arg-Gly-Asp-Ser (GRGDS) p...

journal_title：Macromolecular bioscience

authors： Brunato S,Mastrotto F,Bellato F,Garofalo M,Göddenhenrich T,Mantovani G,Alexander C,Gross S,Salmaso S,Caliceti P

更新日期：2020-11-04 00:00:00

abstract：:A tissue-engineering scaffold resembling the structure of the natural extracellular matrix can often facilitate tissue regeneration. Nerve and tendon are oriented micro-scale tissue bundles. In this study, a method combining injection molding and thermally induced phase separation techniques is developed to create sin...

journal_title：Macromolecular bioscience

authors： Sun C,Jin X,Holzwarth JM,Liu X,Hu J,Gupte MJ,Zhao Y,Ma PX

更新日期：2012-06-01 00:00:00

abstract：:Photo-crosslinkable, fumaric acid monoethyl ester-functionalized triblock oligomers are synthesized and copolymerized with N-vinyl-2-pyrrolidone to form biodegradable photo-crosslinked hydrogels. Poly(ethylene glycol) is used as the middle hydrophilic segment and the hydrophobic segments are based on D,L-lactide, trim...

journal_title：Macromolecular bioscience

authors： Jansen J,Mihov G,Feijen J,Grijpma DW

更新日期：2012-05-01 00:00:00

abstract：:Research and development in the design, synthesis, modification, evaluation, and characterization of polysaccharide-based bioactive polymeric materials for guiding and promoting new tissue in-growth is reviewed. Emphasis is given in this interdisciplinary field of tissue engineering (TE) with particular reference to b...

journal_title：Macromolecular bioscience

authors： Khan F,Ahmad SR

更新日期：2013-04-01 00:00:00

abstract：:pH-responsive amphiphilic graft macromolecules consisting of a polyphosphazene backbone, hydrophilic PEG branches and pH-sensitive DPA were successfully synthesized and characterized. The copolymer can self-assemble into vesicles in an aqueous solution with unique inner structure and homogeneously encapsulate both lip...

journal_title：Macromolecular bioscience

authors： Zheng C,Yao X,Qiu L

更新日期：2011-03-10 00:00:00

abstract：:The repair of large crushed or sectioned segments of peripheral nerves remains a challenge in regenerative medicine due to the complexity of the biological environment and the lack of proper biomaterials and architecture to foster reconstruction. Traditionally such reconstruction is only achieved by using fresh human ...

journal_title：Macromolecular bioscience

authors： Belanger K,Dinis TM,Taourirt S,Vidal G,Kaplan DL,Egles C

更新日期：2016-04-01 00:00:00

abstract：:A redox-responsive poly(ethylene glycol) (PEG)-sheddable copolymer of disulfide-linked PEG 5000-lysine-di-tocopherol succinate (P(5k)SSLV) is developed which can self-assemble into nanomicelles in aqueous condition and trigger the rapid release of encapsulated drugs within tumor cells. The reduction-insensitive doxoru...

journal_title：Macromolecular bioscience

authors： Ai X,Sun J,Zhong L,Wu C,Niu H,Xu T,Lian H,Han X,Ren G,Ding W,Wang J,Pu X,He Z

更新日期：2014-10-01 00:00:00

abstract：:We present a two-fold study designed to elucidate the adhesion mechanism of human U937 monocytes on novel N-rich thin films deposited by plasma- and VUV photo-polymerisation, so-called "PVP:N" materials. It is shown that there exist sharply-defined ("critical") surface-chemical conditions that are necessary to induce ...

journal_title：Macromolecular bioscience

authors： Girard-Lauriault PL,Truica-Marasescu F,Petit A,Wang HT,Desjardins P,Antoniou J,Mwale F,Wertheimer MR

更新日期：2009-09-09 00:00:00

abstract：:Novel molecular ecological techniques were used to study changes in microbial community structure and population during degradation of polylactide (PLA)/organically modified layered silicates (OMLS) nanocomposites. Cloned gene sequences belonging to members of the phyla Actinobacteria and Ascomycota comprized the most...

journal_title：Macromolecular bioscience

authors： Sangwan P,Way C,Wu DY

更新日期：2009-07-07 00:00:00

abstract：:Amylose selectively includes poly(L-lactide) (PLLA) among the poly(lactide)s (PLAs) to produce an inclusion complex when the phosphorylase-catalyzed polymerization of α-D-glucose 1-phosphate is performed in the presence of PLLA, poly(D-lactide) (PDLA), or poly(DL-lactide) (PDLLA) (vine-twining polymerization). This re...

journal_title：Macromolecular bioscience

authors： Kaneko Y,Ueno K,Yui T,Nakahara K,Kadokawa J

更新日期：2011-10-10 00:00:00

abstract：:In this work, the in vivo degradation and tissue compatibility of a novel class of inherently fluorescent copolyanhydrides, P(dCPS:SA), were investigated. It was found that the degradation of the copolyanhydrides increased with the increase of SA content in the copolymers. The in vivo degradation rate of the copolymer...

journal_title：Macromolecular bioscience

authors： Fan J,Li Y,Jiang H,Tang G,Wang L

更新日期：2008-05-13 00:00:00

abstract：:Chitosan is non-toxic, biocompatible, and biodegradable polysaccharide from renewable resources, known to have inherent antibacterial activity, which is mainly due to its polycationic nature. The combining of all assets of chitosan and its derivatives with the unique properties of electrospun nanofibrous materials is ...

journal_title：Macromolecular bioscience

authors： Ignatova M,Manolova N,Rashkov I

更新日期：2013-07-01 00:00:00

abstract：:Different strategies of chemotherapeutics-based combination cancer therapy have presented enhanced antitumor efficiency and are widely used in clinical cancer treatments. However, several drawbacks of the systems for systemic administration, including low drug accumulation at tumor sites and significant systemic side ...

journal_title：Macromolecular bioscience

authors： Yu S,He C,Chen X

更新日期：2018-12-01 00:00:00

abstract：:The naturally occurring edible biopolymer poly(gamma-glutamic acid) (gamma-PGA) is shown to be an efficient chelating agent of vanadium(IV). The structure of poly(gamma-glutamic acid)oxovanadium(IV) (VO-gamma-PGA) complex in solution has been analyzed by electron spin resonance and UV-visible absorption spectra. The e...

journal_title：Macromolecular bioscience

authors： Karmaker S,Saha TK

更新日期：2008-02-11 00:00:00

abstract：:Desferrioxamine (DFO) is a clinically approved, high affinity iron chelator used for the treatment of iron overload. Due to its short half-life and toxicity, DFO is administered for 8-12 h per day, 5-7 d per week. In this manuscript, the influence of molecular properties of hyperbranched polyglycerol (HPG)-DFO conjuga...

journal_title：Macromolecular bioscience

authors： Hamilton JL,Ul-Haq MI,Creagh AL,Haynes CA,Kizhakkedathu JN

更新日期：2017-03-01 00:00:00

abstract：:Multifunctional polymers with defined structure and biocompatibility are critical to the development of drug delivery systems and bioconjugates. In this article, the synthesis, in vitro blood compatibility, cell viability, in vivo circulation, biodistribution, and clearance of hybrid copolymers based on linear and bra...

journal_title：Macromolecular bioscience

authors： Imran ul-haq M,Lai BF,Kizhakkedathu JN

更新日期：2014-10-01 00:00:00

abstract：:The amyloid-β peptide (Aβ) plays a central role in the mechanism of Alzheimer's disease, being the main constituent of the plaque deposits found in AD brains. Aβ amyloid formation and deposition are due to a conformational switching to a β-enriched secondary structure. Our strategy to inhibit Aβ aggregation involves t...

journal_title：Macromolecular bioscience

authors： Saraiva AM,Cardoso I,Saraiva MJ,Tauer K,Pereira MC,Coelho MA,Möhwald H,Brezesinski G

更新日期：2010-10-08 00:00:00

abstract：:A microfluidic technique is described to encapsulate living cells in alginate hydrogel microparticles generated from monodisperse double-emulsion templates. A microcapillary device is used to fabricate double emulsion templates composed of an alginate drop surrounded by a mineral oil shell. Hydrogel formation begins w...

journal_title：Macromolecular bioscience

authors： Martinez CJ,Kim JW,Ye C,Ortiz I,Rowat AC,Marquez M,Weitz D

更新日期：2012-07-01 00:00:00