Abstract:
:Two different composite scaffolds, solid-freeform-fabricated PCL/β-TCP supplemented with and without collagen nanofibers are fabricated. These scaffolds are evaluated whether a combination of collagen nanofibers with PCL/β-TCP can promote osteogenesis in a mastoid obliteration. To assess the effects of the cellular activities of osteoblast-like-cells (MG63), SEM images and MTT assays are conducted. Experimental mastoid obliteration is performed using guinea pigs that are divided group A (PCL/β-TCP/collagen-nanofiber scaffold) and group B (PCL/β-TCP scaffold). The results reveal that PCL/β-TCP/collagen scaffold provide much broader cell attachment sites than PCL/β-TCP scaffold. The µ-CT and fluorescent microscopy results reveal that the acceleration of early new bone formation within the pores and scaffold itself at week 4 post-operation is more effective in group A. In addition, based on the results of the histological and µ-CT at 12 weeks post-surgery, the effective regeneration of bone in the PCL/β-TCP/collagen scaffold is appeared.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Jang CH,Cho YB,Yeo MG,Kim GHdoi
10.1002/mabi.201200393subject
Has Abstractpub_date
2013-05-01 00:00:00pages
660-8issue
5eissn
1616-5187issn
1616-5195journal_volume
13pub_type
杂志文章abstract::Amylose selectively includes poly(L-lactide) (PLLA) among the poly(lactide)s (PLAs) to produce an inclusion complex when the phosphorylase-catalyzed polymerization of α-D-glucose 1-phosphate is performed in the presence of PLLA, poly(D-lactide) (PDLA), or poly(DL-lactide) (PDLLA) (vine-twining polymerization). This re...
journal_title:Macromolecular bioscience
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abstract::Cells in physiological 3D environments differ considerably in morphology and differentiation from those in 2D tissue culture. Naturally derived polymer systems are frequently used to study cells in 3D. These 3D matrices are complex with respect to their chemical composition, mechanical properties, and geometry. Theref...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
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journal_title:Macromolecular bioscience
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abstract::An antioxidant microgel with both glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities is reported. Using computational design and genetic engineering methods, the main catalytic components of GPx are fabricated onto the surface of ferritin. The resulting seleno-ferritin (Se-Fn) monomers can self-ass...
journal_title:Macromolecular bioscience
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journal_title:Macromolecular bioscience
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abstract::Within this work, a new class of sequence-defined heteromultivalent glycomacromolecules bearing lactose residues and nonglycosidic motifs for probing glycoconjugate recognition in carbohydrate recognition domain (CRD) of galectin-3 is presented. Galectins, a family of β-galactoside-binding proteins, are known to play ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
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abstract::A simple continuous flow wet-spinning method to achieve mechanical reinforcement of the two oppositely charged biopolymers chitosan and gellan gum is described. The mechanical properties of these biopolymers are influenced by the order of addition. Using a facile method for mechanical reinforcement of gellan gum/chito...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800257
更新日期:2009-04-08 00:00:00
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journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200274
更新日期:2012-11-01 00:00:00
abstract::Nanotechnology is finding ever increasing application in the life science arena where nanoparticles can be used to deliver cargoes in cells. However, a clear understanding of the relationship between the chemical properties of the particle and its uptake efficiency is lacking. Herein, the effects on particle cellular ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200455
更新日期:2013-06-01 00:00:00
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journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600349
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journal_title:Macromolecular bioscience
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doi:10.1002/mabi.201200167
更新日期:2012-12-01 00:00:00
abstract::Synthetic resins have been extensively employed by artists in their works of art, e.g. as paint binders, or by conservators for conservation treatments, e.g. as stone consolidants and protectives. It is generally thought that synthetic resins are less prone to chemical, physical and biological deterioration than other...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.200300055
更新日期:2004-04-19 00:00:00
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journal_title:Macromolecular bioscience
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journal_title:Macromolecular bioscience
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journal_title:Macromolecular bioscience
pub_type: 杂志文章
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abstract::To explore the potential of a star-shaped 8-armed poly(ethylene glycol)35K-block-poly(L-lactide)37K (8-armed PEG35K-b-PLLA37K: M(n) of PEG = 35 000, M(n) of PLLA = 37 000) film as a novel bioabsorbable adhesion-prevention membrane, the water structure, surface contact angle, protein adsorption, and cell and platelet a...
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journal_title:Macromolecular bioscience
pub_type: 杂志文章
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journal_title:Macromolecular bioscience
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journal_title:Macromolecular bioscience
pub_type: 杂志文章
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abstract::The present study describes the synthesis of novel polypeptides containing O-phospho-L-threonine [Thr(PO(3)H(2))] and L-aspartic acid. Random copolypeptides copoly[Thr(PO(3)H(2))(X)Asp(Y)] (X:Y = 25:75, 50:50, 75:25), were conventionally prepared by copolymerization of Thr(PO(3)Ph(2)) N-carboxyanhydride (NCA) and Asp(...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
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