Abstract:
:Previously synthesized amphiphilic diblock copolymers with pendant dendron moieties have been investigated for their potential use as drug carriers to improve the delivery of an anticancer drug to human breast cancer cells. Diblock copolymer (P71 D3 )-based micelles effectively encapsulate the doxorubicin (DOX) with a high drug-loading capacity (≈95%, 104 DOX molecules per micelle), which is approximately double the amount of drug loaded into the diblock copolymer (P296 D1 ) vesicles. DOX released from the resultant P71 D3 /DOX micelles is approximately 1.3-fold more abundant, at a tumoral acidic pH of 5.5 compared with a pH of 7.4. The P71 D3 /DOX micelles also enhance drug potency in breast cancer MDA-MB-231 cells due to their higher intracellular uptake, by approximately twofold, compared with the vesicular nanocarrier, and free DOX. Micellar nanocarriers are taken up by lysosomes via energy-dependent processes, followed by the release of DOX into the cytoplasm and subsequent translocation into the nucleus, where it exert its cytotoxic effect.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Viswanathan G,Hsu YH,Voon SH,Imae T,Siriviriyanun A,Lee HB,Kiew LV,Chung LY,Yusa Sdoi
10.1002/mabi.201500435subject
Has Abstractpub_date
2016-06-01 00:00:00pages
882-95issue
6eissn
1616-5187issn
1616-5195journal_volume
16pub_type
杂志文章abstract::Intrinsic antimicrobial thermoplastic A(BC)n copolymers (n = 1, 2, 4), where A was poly(ethylene glycol) (PEG), BC was a random chain of methylmethacrylate (MMA), and alkyl-aminoethyl methacrylate (AAEMA), were synthesized and the antimicrobial activity and hemolyticity were evaluated on plaques obtained by casting as...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400503
更新日期:2015-07-01 00:00:00
abstract::Over the past few decades, numerous polymer drug carrier systems are designed and synthesized, and their properties are evaluated. Many of these systems are based on water-soluble polymer carriers of low-molecular-weight drugs and compounds, e.g., cytostatic agents, anti-inflammatory drugs, or multidrug resistance inh...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201700209
更新日期:2018-01-01 00:00:00
abstract::Novel temperature-sensitive poly(N-isopropylacrylamide)/amine-terminated polyamidoamine dendrimer G6-NH2 hydrogels with fast responsive properties were synthesized by forming semi-interpenetrating polymeric networks. In contrast to the conventional PNIPA hydrogel, these new gels showed rapid shrinking rate at the temp...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400003
更新日期:2004-06-25 00:00:00
abstract::Molecularly imprinted polymers (MIPs) are synthetic affinity matrices capable of selective binding a specific target molecule. A strategy for competitive selectivity studies is developed providing information on the selective binding properties of MIPs in complex matrices. Batch rebinding experiments entail the target...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500106
更新日期:2015-11-01 00:00:00
abstract::Reaction of a beta-(1 --> 4) linked galactan with TDMS chloride followed by methylation and desilylation yields methyl galactans with unconventional functionalization patterns. The products were characterized via FTIR and NMR of the intact polymer and by CE after controlled depolymerization. A TDMS-derivatized methyl ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700120
更新日期:2008-01-09 00:00:00
abstract::The nanostructure of a biomaterial surface has strong influence on cell behavior. The migration of cells on nanostructured surfaces, however, has not been investigated so far. In this study, we used PCL/PEG diblock copolymers as model surfaces to examine the effect of nanoislands on migration of different cells, inclu...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600248
更新日期:2007-04-10 00:00:00
abstract::"Three-layered micelles" (3LM) composed of two triblock copolymers, poly(L-lactide)-b-polyethyleneimine-b-poly(L-lactide) (PLLA-PEI-PLLA) and poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) (PLLA-PEG-PLLA) are designed to combine electrostatic interaction and solvent-induced condensation of DNA. The low mole...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400488
更新日期:2015-05-01 00:00:00
abstract::Mucins are high molecular-weight glycoproteins having oligosaccharides attached to serine or threonine residues of the mucin core protein backbone by O-glycosidic linkages. They are major components of mucus, covering the luminal surfaces of epithelial respiratory, gastrointestinal and reproductive tracts, and respons...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.200300099
更新日期:2004-05-17 00:00:00
abstract::The control of biofouling, which is the unwanted adsorption of biomolecules and organisms on solid surfaces, is a prerequisite for wider applicability of the functional materials that are currently being used in biomedical industries. One of the frequently used methods for controlling biofouling is the use of surface ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800137
更新日期:2018-10-01 00:00:00
abstract::Protein hydrophobic interaction has been considered the most important factor dominating protein folding, aggregation, gelling, self-assembly, adhesion, and cohesion properties. In this paper, morphology and phase separation of hydrophobic clusters, networks, and aggregates of soy globular protein polymers, induced by...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700235
更新日期:2008-04-09 00:00:00
abstract::N-Acetyl-l-cysteine (NAC)-capped poly(methyl methacrylate)-b-polycaprolactone block copolymer (PMMA-b-PCL-NAC) was prepared using the previously described one-pot photoinduced sequential CuAAC/thiol-ene double click procedure. PMMA-b-PCL-NAC had previously shown good applicability as a matrix for cell adhesion of cell...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500099
更新日期:2015-09-01 00:00:00
abstract::Poly(vinyl alcohol)-pyrene-anti-metadherin (PVA-Py-(Anti-MTDH)), a novel antibody based water soluble probe containing both fluorescent and target sites in the structure for in vitro imaging of breast cancer cells is reported here. Since breast cancer cells have an excess of MDTH protein expressed on the surface, a PV...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000009
更新日期:2010-06-11 00:00:00
abstract::The preparation of a novel peptide/dendrimer hybrid is reported in which an elastin-like oligopeptide is successfully assembled onto a poly(amidoamine) dendrimer surface (G4-ELP), and its unique thermo-responsive behavior is discussed. As a result, the G4-ELP is found to exhibit LCST behavior in the pH range 3-10 incl...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100509
更新日期:2012-08-01 00:00:00
abstract::In this paper we report on the synthesis of diversified linear polyamine architectures with different chain lengths and compositions and their interaction with phosphate groups of DNA/siRNA. The polyplex formation between model nucleotide (dsDNA) and these linear polyamines has been determined at different nitrogen to...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000082
更新日期:2010-09-09 00:00:00
abstract::Excessive bilirubin in the body of patient with liver dysfunction or metabolic obstruction may cause jaundice with irreversible brain damage, and new type of adsorbent for bilirubin is under frequent investigation. Herein, graphene oxide based core @ polyethersulfone-based shell beads are fabricated by phase inversion...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000153
更新日期:2020-08-01 00:00:00
abstract::A microfluidic technique is described to encapsulate living cells in alginate hydrogel microparticles generated from monodisperse double-emulsion templates. A microcapillary device is used to fabricate double emulsion templates composed of an alginate drop surrounded by a mineral oil shell. Hydrogel formation begins w...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100351
更新日期:2012-07-01 00:00:00
abstract::Amylose selectively includes poly(L-lactide) (PLLA) among the poly(lactide)s (PLAs) to produce an inclusion complex when the phosphorylase-catalyzed polymerization of α-D-glucose 1-phosphate is performed in the presence of PLLA, poly(D-lactide) (PDLA), or poly(DL-lactide) (PDLLA) (vine-twining polymerization). This re...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100133
更新日期:2011-10-10 00:00:00
abstract::3D hydrogels better replicate in vivo conditions, and yield different results from 2D substrates. However, imaging interactions between cells and the hydrogel microenvironment is challenging because of light diffraction and poor focal depth. Here, cryosectioning and vibrating microtomy methods and fixation protocols a...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600478
更新日期:2017-06-01 00:00:00
abstract::The antiviral effects of the cationic acrylate polymer E100 on a panel of lipid-enveloped viruses and the interactions involved are studied. The treatment of several common viruses with E100 induced a dose-dependent inhibition of the infectivity of viruses below the detection limit of the assays employed. Similarly, t...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700102
更新日期:2007-09-11 00:00:00
abstract::Polymeric nanostructures obtained through self-assembly of reduction-sensitive amphiphilic triblock copolymers were investigated as potential drug delivery systems. The characteristic feature of these polymers is their cleavable disulfide bond in the center of the hydrophobic block. Therefore, the triblock copolymers ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400400
更新日期:2015-04-01 00:00:00
abstract::A hybrid system for producing conducting polymers within a doping hydrogel mesh is presented. These conductive hydrogels demonstrate comparable electroactivity to conventional conducting polymers without requiring the need for mobile doping ions which are typically used in literature. These hybrids have superior mecha...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100490
更新日期:2012-04-01 00:00:00
abstract::The present study describes the synthesis of novel polypeptides containing O-phospho-L-threonine [Thr(PO(3)H(2))] and L-aspartic acid. Random copolypeptides copoly[Thr(PO(3)H(2))(X)Asp(Y)] (X:Y = 25:75, 50:50, 75:25), were conventionally prepared by copolymerization of Thr(PO(3)Ph(2)) N-carboxyanhydride (NCA) and Asp(...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200500211
更新日期:2006-03-14 00:00:00
abstract::Highly crystalline amylose-polytetrahydrofuran (PTHF) complexes can be obtained by employing organic solvents as washing agents after complex formation. The X-ray diffraction (XRD) of the washed complexes appear sharp at 12.9°-13.2° and 19.6°-20.1°, clear signs of the presence of V6I -amylose. Other diffraction peaks ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201300174
更新日期:2014-01-01 00:00:00
abstract::The accurate diagnosis and proper therapy for cancer are essential to improve the success rate of cancer treatment. Here, we demonstrated that the vitamin Bc -bearing hydrophilic photosensitizer conjugate folic acid-polyethylene glycol-pheophorbideA (FA-PEG-PheoA) has been synthesized for the intracellular diagnosis a...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500060
更新日期:2015-08-01 00:00:00
abstract::In this study, PLLA nanofibers are fabricated by electrospinning and their surfaces are modified by laminin/chitosan (LN/CS) polyelectrolyte multilayer. Surface C/N ratio determined by XPS analysis quantitatively indicates of discrete coating layers on the nanofibers. The amount of LN deposited sustainably increases w...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201300177
更新日期:2013-11-01 00:00:00
abstract::Blend films of silk fibroin and carboxymethyl chitin were prepared by solution casting using water as a cosolvent. The blend films were subjected to post-treatment with an aqueous methanol solution to induce beta-sheet formation of silk fibroin. The miscibility of the blend films both before and after methanol treatme...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700074
更新日期:2007-12-06 00:00:00
abstract::Synthetic resins have been extensively employed by artists in their works of art, e.g. as paint binders, or by conservators for conservation treatments, e.g. as stone consolidants and protectives. It is generally thought that synthetic resins are less prone to chemical, physical and biological deterioration than other...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.200300055
更新日期:2004-04-19 00:00:00
abstract::Peptide dendrimers assembled by solid-phase peptide synthesis using a branching diamino acid at every 2(nd) or 3(rd) position provide readily accessible synthetic model systems for proteins and enzymes. They adopt a globular shape by topology rather than by folding. Peptide dendrimers of 2(nd) and 3(rd) generation fun...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700036
更新日期:2007-08-07 00:00:00
abstract::Photo-crosslinking and self-healing have received considerable attention for the design of intelligent materials. A novel photostimulated, self-healing, and cytocompatible hydrogel system is reported. A coumarin methacrylate crosslinker is synthesized to modify the polyacrylamide-based hydrogels. With the [2+2] cyclo-...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500457
更新日期:2016-09-01 00:00:00
abstract::The synthesis of a novel nanocapsule-based carrier system is described, possessing a triggered release in remote-controlled fashion upon application of an external magnetic field in combination with the possibility to use the capsules as contrast agents for magnetic resonance imaging (MRI). Therefore, polymeric nanoco...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400122
更新日期:2014-09-01 00:00:00